Entity Details

Primary name Akt1
Entity type gene
Source Source Link

Details

PrimaryID11651
RefseqGene
SymbolAkt1
Namethymoma viral proto-oncogene 1
Chromosome12
Location12 61.2 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsAKT1_MOUSE

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002931 response to ischemia
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007281 germ cell development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008637 apoptotic mitochondrial changes
GO:0008643 carbohydrate transport
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0010507 negative regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010763 positive regulation of fibroblast migration
GO:0010765 positive regulation of sodium ion transport
GO:0010907 positive regulation of glucose metabolic process
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0010951 negative regulation of endopeptidase activity
GO:0010975 regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015630 microtubule cytoskeleton
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021510 spinal cord development
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030235 nitric-oxide synthase regulator activity
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0031397 negative regulation of protein ubiquitination
GO:0031641 regulation of myelination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031982 vesicle
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032079 positive regulation of endodeoxyribonuclease activity
GO:0032091 negative regulation of protein binding
GO:0032094 response to food
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032287 peripheral nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032794 GTPase activating protein binding
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0032929 negative regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034405 response to fluid shear stress
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036064 ciliary basal body
GO:0036294 cellular response to decreased oxygen levels
GO:0038061 NIK/NF-kappaB signaling
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046329 negative regulation of JNK cascade
GO:0046622 positive regulation of organ growth
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051721 protein phosphatase 2A binding
GO:0060416 response to growth hormone
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060716 labyrinthine layer blood vessel development
GO:0070141 response to UV-A
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0071889 14-3-3 protein binding
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 execution phase of apoptosis
GO:0099104 potassium channel activator activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110099 negative regulation of calcium import into the mitochondrion
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900182 positive regulation of protein localization to nucleus
GO:1901653 cellular response to peptide
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903715 regulation of aerobic respiration
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990418 response to insulin-like growth factor stimulus
GO:2000010 positive regulation of protein localization to cell surface
GO:2000402 negative regulation of lymphocyte migration
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
Akt1Trib3IntAct12791994 details
Akt1PplIntAct15102471 details
Akt1Pde3aMINT17124499 details
Akt1ARRB2IntAct16051150 details
Akt1ARRB1IntAct16051150 details
Akt1PTPN1MINT11579209 details
Akt1CALM1BioGRID15840729 details
Akt1BCL2L11BioGRID16282323 details
Akt1H2bc4BioGRID11435472 details
Akt1H2bc18BioGRID9582374 details
Akt1Akt1BioGRID7891724 details
Akt1Ppargc1aBioGRID17554339 details
Akt1Kctd20BioGRID24156551 details
Akt1Sox2BioGRID25042802 details
Akt1Ctnnd1BioGRID17993462 details
Akt1Ccdc88aBioGRID15753085 details
Akt1Gsk3aBioGRID18851840 20576936 21084607 details
Akt1Gsk3bBioGRID18851840 20576936 21084607 32325033 details
Akt1HSP90AA1BioGRID19662498 details
Akt1PDPK1BioGRID19662498 details
Akt1ParvbBioGRID20164304 details
Akt1USP1BioGRID32133736 details
Akt1USP11BioGRID32133736 details
Akt1OTUB2BioGRID32133736 details
Akt1OTUD5BioGRID32133736 details
Akt1OTUD6ABioGRID32133736 details
Akt1Map3k5IntAct11154276 details
Akt1STK4MINT17932490 details
Akt1LmnaDIP, MINT18388859 23686339 details
Akt1Mapkap1MINT18566586 details
Akt1UbbMINT18566586 details
Akt1UbcMINT18566586 details
Akt1Rps27aMINT18566586 details
Akt1Uba52MINT18566586 details
Akt1Hsp90aa1BioGRID, MINT10995457 18566586 details
Akt1Sirt1IntAct21775285 details
Akt1RICTORI2D21339740 details
Akt1PREX1I2D21339740 details
Akt1FAM110CUniProt19698782 details
Akt1Stub1BioGRID, DIP18292230 details
Akt1SrcBioGRID, DIP19122674 details
Akt1Arrb2BioGRID, DIP16051150 19122674 details
Akt1Hdac6BioGRID, IntAct24955524 details
Akt1Btbd10BioGRID18160256 details
Akt1Traf6BioGRID23907468 25808491 details
Akt1Hsp90ab1BioGRID10995457 details
Akt1Pik3r1BioGRID24567360 details
Akt1HTTBioGRID15843398 details
Akt1Ppp2r2bBioGRID16051150 details
Akt1Ppp2caBioGRID16051150 details
Akt1Arrb1BioGRID16051150 19122674 details
Akt1Clip3BioGRID19139280 details
Akt1Mapk14BioGRID17015449 details
Akt1Hspb2BioGRID17015449 details
Akt1Mapkapk2BioGRID17015449 details
Akt1Hspb1BioGRID12740362 details
Akt1VHLBioGRID27563096 details
Akt1VhlBioGRID27563096 details
Akt1IlkBioGRID20164304 details
Akt1IWS1BioGRID24462114 details
Akt1Akt1s1BioGRID24462114 details
Akt1Map4k4BioGRID24462114 details
Akt1Tsc1BioGRID32133736 details
Akt1PrkceIntAct11139474 details
Akt1Foxo1MINT18388859 details
Akt1GapdhMINT18388859 details
Akt1Wdfy2MINT18388859 details
Akt1MtorMINT18566586 details
Akt1InsrBioGRID, DIP19122674 details
Akt1MaptBioGRID32325033 details
Akt1Appl1BioGRID32325033 details
Akt1Pdk2BioGRID32325033 details
Akt1SncbBioGRID32325033 details
Akt1SrrBioGRID32325033 details
Akt1Them4BioGRID32325033 details
Akt1ApohBioGRID32325033 details
Akt1Camkk1BioGRID32325033 details
Akt1Sult4a1BioGRID32325033 details
Akt1Hmox1BioGRID32325033 details
Akt1Bcl10BioGRID32325033 details
Akt1Card11BioGRID32325033 details
Akt1Niban1BioGRID32325033 details
Akt1Phlpp1BioGRID32325033 details
Akt1Uxs1BioGRID32325033 details
Akt1CfdBioGRID30550785 details
Akt1Fndc5BioGRID30550785 details
Akt1Hoxc11IntAct24955524 details
Akt1Hoxc12IntAct24955524 details