Entity Details

Primary name App
Entity type gene
Source Source Link

Details

PrimaryID11820
RefseqGene
SymbolApp
Nameamyloid beta (A4) precursor protein
Chromosome16
Location16 46.92 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsA4_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001664 G protein-coupled receptor binding
GO:0001774 microglial cell activation
GO:0001878 response to yeast
GO:0001934 positive regulation of protein phosphorylation
GO:0001967 suckling behavior
GO:0002265 astrocyte activation involved in immune response
GO:0003682 chromatin binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005769 early endosome
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005911 cell-cell junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006878 cellular copper ion homeostasis
GO:0006897 endocytosis
GO:0006979 response to oxidative stress
GO:0007155 cell adhesion
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007409 axonogenesis
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008088 axo-dendritic transport
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009986 cell surface
GO:0009987 cellular process
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014005 microglia development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016199 axon midline choice point recognition
GO:0016322 neuron remodeling
GO:0016358 dendrite development
GO:0016504 peptidase activator activity
GO:0019722 calcium-mediated signaling
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0019899 enzyme binding
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0030198 extracellular matrix organization
GO:0030424 axon
GO:0030426 growth cone
GO:0030546 signaling receptor activator activity
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0031410 cytoplasmic vesicle
GO:0031594 neuromuscular junction
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033130 acetylcholine receptor binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034185 apolipoprotein binding
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0035066 positive regulation of histone acetylation
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035253 ciliary rootlet
GO:0040014 regulation of multicellular organism growth
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 regulation of protein binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0044304 main axon
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045821 positive regulation of glycolytic process
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046875 ephrin receptor binding
GO:0046914 transition metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048143 astrocyte activation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048669 collateral sprouting in absence of injury
GO:0048786 presynaptic active zone
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050786 RAGE receptor binding
GO:0050803 regulation of synapse structure or activity
GO:0050808 synapse organization
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051087 chaperone binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051233 spindle midzone
GO:0051247 positive regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0051425 PTB domain binding
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0055037 recycling endosome
GO:0060291 long-term synaptic potentiation
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070381 endosome to plasma membrane transport vesicle
GO:0070555 response to interleukin-1
GO:0070851 growth factor receptor binding
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0071320 cellular response to cAMP
GO:0071874 cellular response to norepinephrine stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090647 modulation of age-related behavioral decline
GO:0097449 astrocyte projection
GO:0098815 modulation of excitatory postsynaptic potential
GO:0106003 amyloid-beta complex
GO:0150003 regulation of spontaneous synaptic transmission
GO:1900122 positive regulation of receptor binding
GO:1900181 negative regulation of protein localization to nucleus
GO:1900221 regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902950 regulation of dendritic spine maintenance
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903048 regulation of acetylcholine-gated cation channel activity
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903523 negative regulation of blood circulation
GO:1904022 positive regulation of G protein-coupled receptor internalization
GO:1904472 positive regulation of endothelin production
GO:1904591 positive regulation of protein import
GO:1904646 cellular response to amyloid-beta
GO:1905606 regulation of presynapse assembly
GO:1905893 positive regulation of cellular response to thapsigargin
GO:1905896 positive regulation of cellular response to tunicamycin
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:1905906 regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1905945 regulation of response to calcium ion
GO:1990000 amyloid fibril formation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990535 neuron projection maintenance
GO:1990761 growth cone lamellipodium
GO:1990777 lipoprotein particle
GO:1990812 growth cone filopodium
GO:2000406 positive regulation of T cell migration
GO:2000463 positive regulation of excitatory postsynaptic potential

Diseases

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Interactions

173 interactions

InteractorPartnerSourcesPublicationsLink
AppApbb1MINT11517249 details
AppAPBB1MINT11517249 details
AppAPBA2MINT11517249 details
AppMAPK8IP1MINT11517249 details
AppApbb2MINT11517249 details
AppApbb3MINT11517249 details
AppDab1IntAct, MINT, UniProt10460257 11517249 12826668 details
AppNumbMINT12011466 details
AppNbl1MINT12011466 details
AppAplp1BioGRID, IntAct16193067 17934213 32325033 details
AppAplp2BioGRID, IntAct16193067 17934213 32325033 details
AppCNTN3IntAct18272596 details
AppCNTN4IntAct18272596 details
AppDab2UniProt12826668 details
AppSorl1UniProt16407538 23283322 details
AppStub1BioGRID17317785 27325702 details
AppGga1BioGRID17005855 details
AppUba1BioGRID27325702 details
AppUbe2oBioGRID27325702 details
AppUbe2r2BioGRID27325702 details
AppArih1BioGRID27325702 details
AppHecw1BioGRID27325702 details
AppHuwe1BioGRID27325702 details
AppKcmf1BioGRID27325702 details
AppNedd4BioGRID27325702 details
AppPark7BioGRID27325702 details
AppRnf14BioGRID27325702 details
AppTrim32BioGRID27325702 details
AppUbe3aBioGRID27325702 details
AppUbr3BioGRID27325702 details
AppUbr4BioGRID27325702 details
AppUbr5BioGRID27325702 details
AppCul4aBioGRID27325702 details
AppCul4bBioGRID27325702 details
AppDdb1BioGRID27325702 details
AppDcaf5BioGRID27325702 details
AppDcaf8BioGRID27325702 details
AppFbxo3BioGRID27325702 details
AppFbxo21BioGRID27325702 details
AppFbxl16BioGRID27325702 details
AppCrbnBioGRID27325702 details
AppCand1BioGRID27325702 details
AppCops2BioGRID27325702 details
AppCops3BioGRID27325702 details
AppCops4BioGRID27325702 details
AppCops5BioGRID27325702 details
AppCops6BioGRID27325702 details
AppCops7aBioGRID27325702 details
AppCops7bBioGRID27325702 details
AppCops8BioGRID27325702 details
AppPsmc1BioGRID27325702 details
AppPsmc4BioGRID27325702 details
AppPsmc5BioGRID27325702 details
AppPsmc6BioGRID27325702 details
AppPsmd1BioGRID27325702 details
AppPsmd2BioGRID27325702 details
AppPsmd4BioGRID27325702 details
AppPsmd7BioGRID27325702 details
AppPsmd8BioGRID27325702 details
AppPsmd11BioGRID27325702 details
AppPsmd12BioGRID27325702 details
AppPsmd13BioGRID27325702 details
AppPsmd14BioGRID27325702 details
AppUsp9xBioGRID27325702 details
AppUsp5BioGRID27325702 details
AppUsp7BioGRID27325702 details
AppUsp10BioGRID27325702 details
AppOtub1BioGRID27325702 details
AppUbqln1BioGRID27325702 details
AppUbqln2BioGRID27325702 details
AppUbqln4BioGRID27325702 details
AppGrb2BioGRID27325702 details
AppPin1BioGRID27325702 details
AppMib2BioGRID27325702 details
AppCblbBioGRID27325702 details
AppUbe2nBioGRID27325702 details
AppScamp1BioGRID27325702 details
AppSv2aBioGRID27325702 details
AppSv2bBioGRID27325702 details
AppVamp2BioGRID27325702 details
AppAtp6v0a1BioGRID27325702 details
AppSlc17a7BioGRID27325702 details
AppSyt1BioGRID27325702 details
AppSyt2BioGRID27325702 details
AppRab14BioGRID27325702 details
AppRab3aBioGRID27325702 details
AppSnap25BioGRID27325702 details
AppSyn2BioGRID27325702 details
AppSyn1BioGRID27325702 details
AppApoeBioGRID27325702 details
AppMaptBioGRID27325702 details
AppMapk8ip1MINT11517249 11724784 details
AppApba2IntAct, MINT11517249 20925061 details
AppShc3IntAct11877420 details
AppPrnpBioGRID, IntAct15146195 17934213 details
AppLingo1IntAct17934213 details
AppClstn1IntAct17934213 20925061 details
AppCalrIntAct17934213 23585889 details
AppPIN1IntAct16554819 details
AppAppMINT20573181 details
AppDlg4MINT20573181 details
AppSlc40a1IntAct20817278 details
AppItm2bMINT21587206 details
AppGnao1IntAct23761911 details
AppFlrt3UniProt26960425 details
AppITM2BUniProt16027166 details
AppSort1UniProt23283322 details
AppPpidUniProt18806802 details
AppRasgrf1MINT23719799 details
AppSncaBioGRID18769546 details
AppCpeb1BioGRID16314516 details
AppRanbp9BioGRID19251705 details
AppKdrBioGRID19818105 details
AppMap3k5BioGRID17719230 details
AppNgfrBioGRID19334058 details
AppRelnBioGRID10939329 19515914 details
AppCluBioGRID30295351 details
AppEgfBioGRID33009641 details
AppMAPK8MINT11517249 details
AppYwhabIntAct16635246 details
AppCpeIntAct17934213 details
AppClstn3IntAct17934213 details
AppErp44IntAct17934213 details
AppAtp2b2IntAct17934213 details
AppNfascIntAct17934213 details
AppGanabIntAct17934213 details
AppSrgap3IntAct17934213 details
AppHyou1IntAct17934213 details
AppGabbr1IntAct17934213 details
AppRcn2IntAct17934213 details
AppNcam1IntAct17934213 details
AppCntn1IntAct17934213 details
AppCanxIntAct17934213 details
AppHsp90b1IntAct17934213 details
AppPpibIntAct17934213 details
AppEpb41l3IntAct17934213 details
AppPpp1r2IntAct17934213 details
AppCaluIntAct17934213 details
AppPdia6IntAct17934213 details
AppMat1aIntAct17934213 details
AppOatIntAct17934213 details
AppSpon1IntAct17934213 details
AppThy1IntAct17934213 details
AppHspa5IntAct17934213 details
AppSparcl1IntAct17934213 details
AppCst3IntAct17934213 details
AppRab11aIntAct20925061 details
AppStx12IntAct20925061 details
AppArcIntAct22036569 details
AppDnm2IntAct22036569 details
AppFlot2IntAct22036569 details
AppNcstnIntAct22036569 details
AppSh3gl1IntAct22036569 details
AppSh3gl3IntAct22036569 details
AppBACE1MINT25957769 details
AppClec4gMINT25957769 details
AppAcsbg1BioGRID32325033 details
AppGfapBioGRID32325033 details
AppBdh1BioGRID32325033 details
AppRufy3BioGRID32325033 details
AppApba1BioGRID32325033 details
AppNeflBioGRID32325033 details
AppAtcayBioGRID32325033 details
AppGolm2BioGRID32325033 details
AppEny2BioGRID32325033 details
AppPrxl2aBioGRID32325033 details
AppGsk3aBioGRID32325033 details
App6430548M08RikBioGRID32325033 details
AppLrp1BioGRID32325033 details
AppNecab1BioGRID32325033 details
AppRlbp1BioGRID32325033 details
AppTmod2BioGRID32325033 details
AppVps33bBioGRID32325033 details