Entity Details

Primary name Brca1
Entity type gene
Source Source Link

Details

PrimaryID12189
RefseqGene
SymbolBrca1
Namebreast cancer 1, early onset
Chromosome11
Location11 65.18 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsBRCA1_MOUSE

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0000976 transcription cis-regulatory region binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006633 fatty acid biosynthetic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007098 centrosome cycle
GO:0008270 zinc ion binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0010212 response to ionizing radiation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0016567 protein ubiquitination
GO:0016604 nuclear body
GO:0019899 enzyme binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031436 BRCA1-BARD1 complex
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042307 positive regulation of protein import into nucleus
GO:0042802 identical protein binding
GO:0043009 chordate embryonic development
GO:0043627 response to estrogen
GO:0044030 regulation of DNA methylation
GO:0044818 mitotic G2/M transition checkpoint
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045739 positive regulation of DNA repair
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051298 centrosome duplication
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051865 protein autoubiquitination
GO:0070063 RNA polymerase binding
GO:0070512 positive regulation of histone H4-K20 methylation
GO:0070531 BRCA1-A complex
GO:0071356 cellular response to tumor necrosis factor
GO:0071681 cellular response to indole-3-methanol
GO:0085020 protein K6-linked ubiquitination
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1990904 ribonucleoprotein complex
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000620 positive regulation of histone H4-K16 acetylation

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
Brca1UbbDIP19088202 details
Brca1UbcBioGRID, DIP19088202 28190767 details
Brca1Rps27aDIP19088202 details
Brca1Uba52DIP19088202 details
Brca1Ewsr1BioGRID, IntAct20211142 details
Brca1Hoxc12BioGRID, IntAct20211142 details
Brca1Hoxa2BioGRID, IntAct20211142 details
Brca1Tcf3BioGRID, IntAct20211142 details
Brca1Olig1BioGRID, IntAct20211142 details
Brca1Brca2BioGRID11477095 20211142 details
Brca1Brca1BioGRID19088202 details
Brca1UBE2D3BioGRID19088202 details
Brca1Atf2BioGRID17700520 details
Brca1Pou2f1BioGRID17700520 details
Brca1Nf1BioGRID17700520 details
Brca1Smarca2BioGRID15574597 details
Brca1NbnBioGRID12792649 details
Brca1Npm1BioGRID18809582 details
Brca1Acot7BioGRID22034435 details
Brca1Rad51BioGRID11477095 details
Brca1Mdc1BioGRID18678890 details
Brca1Esr1BioGRID16807234 details
Brca1JunBioGRID16807234 details
Brca1Etv4BioGRID16807234 details
Brca1UBCBioGRID10500182 details
Brca1AcacaBioGRID24565757 details
Brca1Palb2BioGRID30289697 details
Brca1Ezh2BioGRID, MINT23624935 details
Brca1Suz12BioGRID, MINT23624935 details
Brca1MSH5BioGRID, IntAct26496610 details
Brca1UXTBioGRID, IntAct26496610 details
Brca1SCLT1BioGRID, IntAct26496610 details
Brca1DNPH1BioGRID, IntAct26496610 details
Brca1BLMHBioGRID, IntAct26496610 details
Brca1SMCHD1BioGRID, IntAct26496610 details
Brca1ABCE1BioGRID, IntAct26496610 details
Brca1PRPF38ABioGRID, IntAct26496610 details
Brca1BARD1BioGRID, IntAct26496610 details
Brca1CETN2BioGRID, IntAct26496610 details
Brca1MYH6BioGRID, IntAct26496610 details
Brca1BADBioGRID, IntAct26496610 details
Brca1NanogBioGRID23892456 details
Brca1NDST1BioGRID26496610 details
Brca1Chaf1aBioGRID26365490 details
Brca1Kntc1BioGRID32325033 details
Brca1Taf5lBioGRID32325033 details