Entity Details

Primary name Cdk4
Entity type gene
Source Source Link

Details

PrimaryID12567
RefseqGene
SymbolCdk4
Namecyclin-dependent kinase 4
Chromosome10
Location10
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsCDK4_MOUSE

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016301 kinase activity
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
Cdk4Ccnd1BioGRID, DIP, I2D, IntAct, MINT12588994 12970760 16102793 16331266 16413468 16413469 16627785 16864783 17081987 17699765 17940036 17948060 19409388 20150892 20516642 20951943 21242975 21306487 23707388 details
Cdk4RB1IntAct17045206 17349581 details
Cdk4Ppp1ccBioGRID, IntAct17274640 details
Cdk4PuraBioGRID15707957 details
Cdk4SetBioGRID17309103 details
Cdk4RUNX3BioGRID19351720 details
Cdk4Rb1BioGRID11254678 15158336 8547220 details
Cdk4CebpaBioGRID11867521 15107404 20516642 details
Cdk4H1f1BioGRID12007403 details
Cdk4H1f2BioGRID12970760 details
Cdk4Hsp90aa1BioGRID11867521 details
Cdk4H1f5BioGRID16627785 details
Cdk4MEF2DBioGRID25733682 details
Cdk4OTUD4BioGRID31138677 details
Cdk4Cdkn1bBioGRID, DIP, IntAct11967266 16413468 17699765 19276117 8033213 8822197 details
Cdk4Ccnd3BioGRID, IntAct11254678 16413469 23948297 details
Cdk4Ccnd2BioGRID, IntAct16413469 23948297 9584157 details
Cdk4CCND1MINT19409388 details
Cdk4RGL2I2D21242975 details
Cdk4Cdkn1aBioGRID11967266 12970760 18729080 details
Cdk4Psmd10BioGRID20516642 details
Cdk4PcnaBioGRID12970760 details
Cdk4Hspa8BioGRID12588994 details
Cdk4Cdc37BioGRID11867521 details
Cdk4Cep57BioGRID21306487 details
Cdk4SETIntAct17309103 details
Cdk4Prmt5IntAct20951943 details
Cdk4Wdr77IntAct20951943 details
Cdk4CDKN1BIntAct21423803 details
Cdk4Cdkn2aDIP17713536 details
Cdk4Cdkn2cDIP17713536 details
Cdk4Cdkn2bDIP17713536 details
Cdk4TGFBR1BioGRID15761153 details
Cdk4BMPR1BBioGRID15761153 details
Cdk4Wdtc1BioGRID27113764 details