Entity Details

Primary name Cdkn2a
Entity type gene
Source Source Link

Details

PrimaryID12578
RefseqGene
SymbolCdkn2a
Namecyclin dependent kinase inhibitor 2A
Chromosome4
Location4 42.15 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-08
ModificationDate2021-06-23

Ontological Relatives

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000422 autophagy of mitochondrion
GO:0001652 granular component
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006364 rRNA processing
GO:0006469 negative regulation of protein kinase activity
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007568 aging
GO:0007569 cell aging
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008544 epidermis development
GO:0008637 apoptotic mitochondrial changes
GO:0009303 rRNA transcription
GO:0010243 response to organonitrogen compound
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0019789 SUMO transferase activity
GO:0019901 protein kinase binding
GO:0030308 negative regulation of cell growth
GO:0030889 negative regulation of B cell proliferation
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033235 positive regulation of protein sumoylation
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035019 somatic stem cell population maintenance
GO:0035985 senescence-associated heterochromatin focus
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0047485 protein N-terminus binding
GO:0048103 somatic stem cell division
GO:0050821 protein stabilization
GO:0051059 NF-kappaB binding
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051882 mitochondrial depolarization
GO:0055105 ubiquitin-protein transferase inhibitor activity
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0070301 cellular response to hydrogen peroxide
GO:0070534 protein K63-linked ubiquitination
GO:0090398 cellular senescence
GO:0090399 replicative senescence
GO:0097371 MDM2/MDM4 family protein binding
GO:0097718 disordered domain specific binding
GO:1900182 positive regulation of protein localization to nucleus
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1903214 regulation of protein targeting to mitochondrion
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:1990000 amyloid fibril formation
GO:1990948 ubiquitin ligase inhibitor activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000346 negative regulation of hepatocyte proliferation
GO:2000435 negative regulation of protein neddylation
GO:2000774 positive regulation of cellular senescence

Diseases

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Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
Cdkn2aPpp1caBioGRID, IntAct17274640 details
Cdkn2aPpp1ccBioGRID, IntAct17274640 details
Cdkn2aPEX19BioGRID, UniProt11259404 12154087 12581788 details
Cdkn2aPex19BioGRID, UniProt11259404 16582619 details
Cdkn2aMdm2BioGRID, IntAct10713175 15485902 20832751 22378045 23580573 details
Cdkn2aMDM2BioGRID10713175 11718560 details
Cdkn2aTbrg1BioGRID16582619 17110379 details
Cdkn2aGspt1BioGRID16582619 details
Cdkn2aZfp91BioGRID16582619 details
Cdkn2aHsp90ab1BioGRID16582619 details
Cdkn2aRabl6BioGRID16582619 details
Cdkn2aEif3aBioGRID16582619 details
Cdkn2aRpl9BioGRID16582619 details
Cdkn2aRps7BioGRID16582619 details
Cdkn2aPpp1r9bBioGRID16582619 details
Cdkn2aSpp1BioGRID16582619 details
Cdkn2aTuba1aBioGRID16582619 details
Cdkn2aTpi1BioGRID16582619 details
Cdkn2aCDKN2AIPBioGRID12154087 12581788 details
Cdkn2aZfp93BioGRID16582619 details
Cdkn2aUbcBioGRID28190767 details
Cdkn2aC1QBPUniProt17486078 details
Cdkn2aSp1BioGRID, DIP21555589 details
Cdkn2aNPM1BioGRID, DIP, IntAct16540653 17277230 23851489 details
Cdkn2aNPM2IntAct16540653 details
Cdkn2aHuwe1BioGRID22754359 details
Cdkn2aBcl6BioGRID15567177 details
Cdkn2aTrp53BioGRID10706102 15989966 9653180 details
Cdkn2aNpm1BioGRID15485902 details
Cdkn2aMycBioGRID15361884 details
Cdkn2aMaxBioGRID15361884 details
Cdkn2aBcl2l1BioGRID19049976 details
Cdkn2aCdkn2aipBioGRID12154087 details
Cdkn2aHmga2IntAct26045162 details
Cdkn2aCdk4DIP17713536 details
Cdkn2aPax2BioGRID32325033 details
Cdkn2aCfdBioGRID30550785 details
Cdkn2aFndc5BioGRID30550785 details
Cdkn2aTle1IntAct22439931 details
Cdkn2aAtf2IntAct22439931 details
Cdkn2aCdk6IntAct23948297 details
Cdkn2aStat3IntAct23948297 details
Cdkn2aCcnd2IntAct23948297 details