Entity Details

Primary name Dab2
Entity type gene
Source Source Link

Details

PrimaryID13132
RefseqGene
SymbolDab2
Namedisabled 2, mitogen-responsive phosphoprotein
Chromosome15
Location15 2.15 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-19
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsDAB2_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000904 cell morphogenesis involved in differentiation
GO:0001650 fibrillar center
GO:0001701 in utero embryonic development
GO:0001921 positive regulation of receptor recycling
GO:0001934 positive regulation of protein phosphorylation
GO:0002092 positive regulation of receptor internalization
GO:0005178 integrin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006898 receptor-mediated endocytosis
GO:0006907 pinocytosis
GO:0006915 apoptotic process
GO:0007257 obsolete activation of JUN kinase activity
GO:0007492 endoderm development
GO:0007588 excretion
GO:0008022 protein C-terminus binding
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010977 negative regulation of neuron projection development
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0030099 myeloid cell differentiation
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030276 clathrin binding
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030665 clathrin-coated vesicle membrane
GO:0032091 negative regulation of protein binding
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0035026 leading edge cell differentiation
GO:0035091 phosphatidylinositol binding
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048268 clathrin coat assembly
GO:0048471 perinuclear region of cytoplasm
GO:0048545 response to steroid hormone
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071425 hematopoietic stem cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity
GO:2000370 positive regulation of clathrin-dependent endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2000860 positive regulation of aldosterone secretion
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
Dab2ITGB5MINT12606711 details
Dab2ITGB3MINT12606711 details
Dab2ITGB7MINT12606711 details
Dab2NostrinBioGRID, UniProt15596140 32325033 details
Dab2Necap1MINT17762867 details
Dab2MYO6UniProt11967127 22323290 details
Dab2FCHO2UniProt22323290 details
Dab2EPS15BioGRID, UniProt22323290 22648170 details
Dab2Pias2UniProt11104669 details
Dab2AppUniProt12826668 details
Dab2Eps15l1UniProt22648170 details
Dab2Eps15UniProt22648170 details
Dab2Axin1MINT, UniProt12805222 19581931 details
Dab2Ppp1caMINT19581931 details
Dab2AP2A2UniProt22323290 details
Dab2GRB2UniProt22323290 9569023 details
Dab2Grb2UniProt9569023 details
Dab2Csf1rUniProt9569023 details
Dab2DVL2UniProt12805222 details
Dab2DVL1UniProt12805222 details
Dab2DVL3UniProt12805222 details
Dab2Dvl2UniProt12805222 details
Dab2Dvl3UniProt12805222 details
Dab2Itgb1UniProt15734730 details
Dab2Map3k7UniProt15894542 details
Dab2Itsn1UniProt22648170 details
Dab2SH3KBP1UniProt14596919 details
Dab2Sh3kbp1UniProt14596919 details
Dab2Flt4DIP23354168 details
Dab2Pard3DIP23354168 details
Dab2Tsc22d3BioGRID11104669 details
Dab2ITSN1BioGRID22648170 details
Dab2Lrp2BioGRID12413896 details
Dab2Tsc1BioGRID32133736 details
Dab2HSPA1AUniProt22323290 details
Dab2HSPA1BUniProt22323290 details
Dab2AP2B1UniProt22323290 details
Dab2HSPH1UniProt22323290 details
Dab2RTRAFUniProt22323290 details
Dab2AURKAUniProt22323290 details
Dab2HNRNPLUniProt22323290 details
Dab2TRIOUniProt22323290 details
Dab2PYCR1UniProt22323290 details
Dab2CPSF6UniProt22323290 details
Dab2CLTCUniProt22323290 details
Dab2ACOT9UniProt22323290 details
Dab2AP2A1UniProt22323290 details
Dab2SEC24BUniProt22323290 details
Dab2MALT1UniProt22323290 details
Dab2NUP155UniProt22323290 details
Dab2AP2M1UniProt22323290 details
Dab2PRDX1UniProt22323290 details
Dab2SF3B2UniProt22323290 details
Dab2ACTBUniProt22323290 details
Dab2CCNT1UniProt22323290 details
Dab2SEC23BUniProt22323290 details
Dab2YLPM1UniProt22323290 details
Dab2AHCYUniProt22323290 details
Dab2CPSF7UniProt22323290 details
Dab2KdrDIP23354168 details
Dab2EedBioGRID24457600 details
Dab2Trpv1BioGRID30335684 details
Dab2Mmp2BioGRID32325033 details
Dab2Usp1BioGRID32133736 details
Dab2Wdr48BioGRID32133736 details
Dab2Phlpp1BioGRID32133736 details
Dab2Foxo3BioGRID32133736 details