Entity Details

Primary name Ddx3x
Entity type gene
Source Source Link

Details

PrimaryID13205
RefseqGene
SymbolDdx3x
NameDEAD box helicase 3, X-linked
ChromosomeX
LocationX 8.17 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsDDX3X_MOUSE

GO terms

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GOName
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003924 GTPase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006413 translational initiation
GO:0006954 inflammatory response
GO:0007059 chromosome segregation
GO:0007276 gamete generation
GO:0008134 transcription factor binding
GO:0008143 poly(A) binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615 response to virus
GO:0010494 cytoplasmic stress granule
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0016887 ATP hydrolysis activity
GO:0017111 nucleoside-triphosphatase activity
GO:0017148 negative regulation of translation
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031053 primary miRNA processing
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031369 translation initiation factor binding
GO:0031954 positive regulation of protein autophosphorylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0033592 RNA strand annealing activity
GO:0034063 stress granule assembly
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034161 positive regulation of toll-like receptor 8 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035613 RNA stem-loop binding
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042256 mature ribosome assembly
GO:0043015 gamma-tubulin binding
GO:0043024 ribosomal small subunit binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043186 P granule
GO:0043273 CTPase activity
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043539 protein serine/threonine kinase activator activity
GO:0045070 positive regulation of viral genome replication
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045948 positive regulation of translational initiation
GO:0048027 mRNA 5'-UTR binding
GO:0055088 lipid homeostasis
GO:0071243 cellular response to arsenic-containing substance
GO:0071470 cellular response to osmotic stress
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072559 NLRP3 inflammasome complex
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901985 positive regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903608 protein localization to cytoplasmic stress granule
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
Ddx3xTBK1MINT18583960 details
Ddx3xRaraBioGRID18495661 details
Ddx3xYwhabIntAct16635246 details
Ddx3xTbk1MINT18583960 details
Ddx3xRpgrip1lIntAct21565611 details
Ddx3xTrpm7IntAct24855944 details
Ddx3xCblIntAct27474268 details
Ddx3xPpp1cabhf-ucl25593058 details
Ddx3xHerc2BioGRID, IntAct28671696 details
Ddx3xMycbp2BioGRID, IntAct28671696 details
Ddx3xTnikBioGRID, IntAct28671696 details
Ddx3xPSAPUniProt26370502 details
Ddx3xLRSAM1IntAct27615052 details
Ddx3xMecp2MINT24270455 details
Ddx3xEedBioGRID24457600 details
Ddx3xMKRN1BioGRID26265008 details
Ddx3xABCG1BioGRID26296893 details
Ddx3xPTENBioGRID18307411 details
Ddx3xHnrnpkBioGRID26336360 details
Ddx3xZbtb7bBioGRID28784777 32098917 details
Ddx3xYWHAZBioGRID29530978 details
Ddx3xDcun1d1BioGRID32325033 details
Ddx3xDdx17BioGRID32325033 details
Ddx3xElavl1BioGRID32325033 details
Ddx3xEwsr1BioGRID32325033 details
Ddx3xMagohBioGRID32325033 details
Ddx3xRps13BioGRID32325033 details
Ddx3xRps25BioGRID32325033 details
Ddx3xEif3fBioGRID32325033 details
Ddx3xHnrnpul1BioGRID32325033 details
Ddx3xMcts1BioGRID32325033 details
Ddx3xSrrm2BioGRID32325033 details
Ddx3xAtxn2lBioGRID32325033 details
Ddx3xDdx1BioGRID32325033 details
Ddx3xAtxn2BioGRID32325033 details
Ddx3xDdx6BioGRID32325033 details
Ddx3xDhx15BioGRID32325033 details
Ddx3xEif3aBioGRID32325033 details
Ddx3xEif4eBioGRID32325033 details
Ddx3xFusBioGRID32325033 details
Ddx3xHnrnph1BioGRID32325033 details
Ddx3xPabpc1BioGRID32325033 details
Ddx3xRpl30BioGRID32325033 details
Ddx3xRps10BioGRID32325033 details
Ddx3xRps11BioGRID32325033 details
Ddx3xRps14BioGRID32325033 details
Ddx3xRps15aBioGRID32325033 details
Ddx3xRps16BioGRID32325033 details
Ddx3xRps18BioGRID32325033 details
Ddx3xRps2BioGRID32325033 details
Ddx3xRps20BioGRID32325033 details
Ddx3xRps24BioGRID32325033 details
Ddx3xRps26BioGRID32325033 details
Ddx3xRps27aBioGRID32325033 details
Ddx3xRps3BioGRID32325033 details
Ddx3xRps3a1BioGRID32325033 details
Ddx3xRps4xBioGRID32325033 details
Ddx3xRps6BioGRID32325033 details
Ddx3xRps7BioGRID32325033 details
Ddx3xRps8BioGRID32325033 details
Ddx3xRpsaBioGRID32325033 details
Ddx3xYbx1BioGRID32325033 details
Ddx3xEif2s1BioGRID32325033 details
Ddx3xEif3bBioGRID32325033 details
Ddx3xEif3cBioGRID32325033 details
Ddx3xEif3lBioGRID32325033 details
Ddx3xEif4a3BioGRID32325033 details
Ddx3xGtf2iBioGRID32325033 details
Ddx3xHnrnpuBioGRID32325033 details
Ddx3xIlf2BioGRID32325033 details
Ddx3xIlf3BioGRID32325033 details
Ddx3xLsm14aBioGRID32325033 details
Ddx3xRps19BioGRID32325033 details
Ddx3xRps21BioGRID32325033 details
Ddx3xRps27BioGRID32325033 details
Ddx3xRps9BioGRID32325033 details
Ddx3xTardbpBioGRID32325033 details
Ddx3xRpl6BioGRID32325033 details
Ddx3xRps23BioGRID32325033 details
Ddx3xRps28BioGRID32325033 details
Ddx3xTia1BioGRID32325033 details
Ddx3xEif4g1BioGRID32325033 details
Ddx3xIgsf8BioGRID32325033 details
Ddx3xSnd1BioGRID32325033 details
Ddx3xTdrd3BioGRID32325033 details
Ddx3xPsapBioGRID26370502 details