Entity Details

Primary name TREX1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ91XB0
EntryNameTREX1_MOUSE
FullNameThree-prime repair exonuclease 1
TaxID10090
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesTrex1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000738 DNA catabolic process, exonucleolytic
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0002250 adaptive immune response
GO:0002251 organ or tissue specific immune response
GO:0002253 activation of immune response
GO:0002281 macrophage activation involved in immune response
GO:0002320 lymphoid progenitor cell differentiation
GO:0002383 immune response in brain or nervous system
GO:0002437 inflammatory response to antigenic stimulus
GO:0002457 T cell antigen processing and presentation
GO:0002637 regulation of immunoglobulin production
GO:0003007 heart morphogenesis
GO:0003015 heart process
GO:0003228 atrial cardiac muscle tissue development
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006091 generation of precursor metabolites and energy
GO:0006110 regulation of glycolytic process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006304 DNA modification
GO:0006308 DNA catabolic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0008250 oligosaccharyltransferase complex
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008301 DNA binding, bending
GO:0008340 determination of adult lifespan
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0009411 response to UV
GO:0010468 regulation of gene expression
GO:0019217 regulation of fatty acid metabolic process
GO:0031323 regulation of cellular metabolic process
GO:0032197 transposition, RNA-mediated
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0032479 regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0032558 adenyl deoxyribonucleotide binding
GO:0032680 regulation of tumor necrosis factor production
GO:0032993 protein-DNA complex
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034644 cellular response to UV
GO:0035458 cellular response to interferon-beta
GO:0035781 CD86 biosynthetic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043277 apoptotic cell clearance
GO:0043457 regulation of cellular respiration
GO:0043596 nuclear replication fork
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045184 establishment of protein localization
GO:0046890 regulation of lipid biosynthetic process
GO:0050699 WW domain binding
GO:0050727 regulation of inflammatory response
GO:0050790 regulation of catalytic activity
GO:0050821 protein stabilization
GO:0050863 regulation of T cell activation
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061635 regulation of protein complex stability
GO:0071310 cellular response to organic substance
GO:0071357 cellular response to type I interferon
GO:0071480 cellular response to gamma radiation
GO:0072394 obsolete detection of stimulus involved in cell cycle checkpoint
GO:0072421 obsolete detection of DNA damage stimulus involved in DNA damage checkpoint
GO:0072711 cellular response to hydroxyurea
GO:0097281 immune complex formation
GO:1904161 DNA synthesis involved in UV-damage excision repair
GO:1905671 regulation of lysosome organization

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR013520 Exonuclease, RNase T/DNA polymerase IIIDomainDomain
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TREX1_MOUSETREX1_MOUSEBioGRID17293595 details