Entity Details

Primary name Egfr
Entity type gene
Source Source Link

Details

PrimaryID13649
RefseqGene
SymbolEgfr
Nameepidermal growth factor receptor
Chromosome11
Location11 9.41 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsEGFR_MOUSE

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000186 obsolete activation of MAPKK activity
GO:0000902 cell morphogenesis
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0003682 chromatin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006412 translation
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007435 salivary gland morphogenesis
GO:0007494 midgut development
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008544 epidermis development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0010960 magnesium ion homeostasis
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016101 diterpenoid metabolic process
GO:0016301 kinase activity
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021795 cerebral cortex cell migration
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031625 ubiquitin protein ligase binding
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033590 response to cobalamin
GO:0033594 response to hydroxyisoflavone
GO:0033674 positive regulation of kinase activity
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042698 ovulation cycle
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043586 tongue development
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045780 positive regulation of bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048143 astrocyte activation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048408 epidermal growth factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048546 digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051015 actin filament binding
GO:0051592 response to calcium ion
GO:0051897 positive regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060252 positive regulation of glial cell proliferation
GO:0060571 morphogenesis of an epithelial fold
GO:0061029 eyelid development in camera-type eye
GO:0070141 response to UV-A
GO:0070257 positive regulation of mucus secretion
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0097489 multivesicular body, internal vesicle lumen
GO:0098609 cell-cell adhesion
GO:1900020 positive regulation of protein kinase C activity
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902722 positive regulation of prolactin secretion
GO:1902966 positive regulation of protein localization to early endosome
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905208 negative regulation of cardiocyte differentiation

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
EgfrEps15BioGRID, MINT10953014 16862145 details
EgfrEGFMINT21439278 details
EgfrCblBioGRID, MINT14691459 17139251 17372273 20298671 23027125 23457600 23799367 32325033 7657591 details
EgfrGrb2BioGRID, MINT11896055 17372273 20676128 23027125 23799367 7689150 8264620 9363897 details
EgfrJak2BioGRID9038232 9363897 details
EgfrSTAT1BioGRID7657660 details
EgfrEgfrBioGRID20676128 details
EgfrVav1BioGRID7689150 details
EgfrOTUD4BioGRID31138677 details
EgfrDok2MINT15831486 details
EgfrSocs5BioGRID, MINT15695332 details
EgfrEgfMINT2022652 details
EgfrPTPN1MINT18515860 details
EgfrPtpn12MINT12614164 details
EgfrKrasIntAct22975374 details
EgfrAGERDIP16954185 details
EgfrItgb3DIP17606926 details
EgfrLingo1DIP17726113 details
EgfrUbbDIP20308550 details
EgfrUbcDIP20308550 details
EgfrRps27aDIP20308550 details
EgfrUba52DIP20308550 details
EgfrChia1IntAct18824549 details
EgfrLrig1IntAct15345710 details
EgfrPRKNBioGRID16862145 details
EgfrMapk14BioGRID17139251 details
EgfrArhgef7BioGRID16892055 details
EgfrErbb2BioGRID21044682 23027125 details
EgfrTyk2BioGRID9038232 details
EgfrSrcBioGRID11274221 details
EgfrShc1BioGRID20676128 7538132 7689150 details
EgfrPpp1r13bBioGRID23027125 details
EgfrPtpn11BioGRID23027125 details
EgfrSos1BioGRID23027125 8479540 details
EgfrOsmrBioGRID27110918 details
EgfrEGFRBioGRID2915986 details
EgfrItgb4BioGRID25202019 details
EgfrAp2a1BioGRID7534311 details
EgfrAp1b1BioGRID7534311 details
EgfrPpp1ccBioGRID17274640 details
EgfrFancd2BioGRID28378742 details
EgfrCibar1BioGRID29459677 details
EgfrTtc23BioGRID29459677 details
EgfrTedc2BioGRID29459677 details
EgfrWdtc1BioGRID27113764 details
EgfrLrp1BioGRID32325033 details
EgfrRnmtBioGRID32325033 details
EgfrPtpraBioGRID32325033 details
EgfrPtprn2BioGRID32325033 details
EgfrSnx4BioGRID32325033 details
EgfrMttpBioGRID32325033 details
EgfrNtrk2BioGRID32325033 details
EgfrCfdBioGRID30550785 details
EgfrFndc5BioGRID30550785 details
EgfrH3f3aIntAct20211137 details
EgfrH3f3bIntAct20211137 details