Entity Details

Primary name Ezh2
Entity type gene
Source Source Link

Details

PrimaryID14056
RefseqGene
SymbolEzh2
Nameenhancer of zeste 2 polycomb repressive complex 2 subunit
Chromosome6
Location6 22.92 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsEZH2_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001932 regulation of protein phosphorylation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006348 chromatin silencing at telomere
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014013 regulation of gliogenesis
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016571 histone methylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0021695 cerebellar cortex development
GO:0021766 hippocampus development
GO:0030183 B cell differentiation
GO:0031490 chromatin DNA binding
GO:0032355 response to estradiol
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 ESC/E(Z) complex
GO:0035984 cellular response to trichostatin A
GO:0036333 hepatocyte homeostasis
GO:0042054 histone methyltransferase activity
GO:0042127 regulation of cell population proliferation
GO:0042752 regulation of circadian rhythm
GO:0043021 ribonucleoprotein complex binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043547 positive regulation of GTPase activity
GO:0043565 sequence-specific DNA binding
GO:0045120 pronucleus
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048468 cell development
GO:0048511 rhythmic process
GO:0050767 regulation of neurogenesis
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0070314 G1 to G0 transition
GO:0070734 histone H3-K27 methylation
GO:0070878 primary miRNA binding
GO:0071168 protein localization to chromatin
GO:0071707 immunoglobulin heavy chain V-D-J recombination
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097421 liver regeneration
GO:0098532 histone H3-K27 trimethylation
GO:1900006 positive regulation of dendrite development
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904772 response to tetrachloromethane
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

98 interactions

InteractorPartnerSourcesPublicationsLink
Ezh2EedBioGRID, DIP, IntAct, MINT12900441 17937919 20064375 20064376 20075857 22094255 22438827 23624935 24457600 25680957 9742080 details
Ezh2BRCA1MINT23624935 details
Ezh2Dnmt3lIntAct24074865 details
Ezh2Cited4BioGRID, IntAct20211142 details
Ezh2H3-4BioGRID22619169 details
Ezh2Myod1BioGRID22333916 details
Ezh2H3f3aBioGRID23948251 details
Ezh2AtrxBioGRID25417162 details
Ezh2Suz12BioGRID, DIP, IntAct, MINT20064375 20064376 20075857 20123894 22438827 23624935 24040135 24074865 25680957 details
Ezh2Jarid2BioGRID, DIP, IntAct, MINT20064375 20064376 20075857 20123894 21811233 25680957 details
Ezh2Mtf2BioGRID, IntAct20064376 20123894 25680957 details
Ezh2Rbbp4BioGRID, IntAct20064376 20123894 25680957 details
Ezh2Aebp2BioGRID, IntAct20064376 20123894 25680957 details
Ezh2Phf1BioGRID20123894 32325033 details
Ezh2ClockBioGRID16717091 details
Ezh2ArntlBioGRID16717091 details
Ezh2Cry1BioGRID16717091 details
Ezh2Rbl2BioGRID15077161 details
Ezh2Phf19BioGRID22438827 23104054 details
Ezh2H1f7BioGRID22323620 details
Ezh2Polr2aBioGRID22305566 details
Ezh2Cul3BioGRID23086144 details
Ezh2Ss18BioGRID22439931 details
Ezh2Asxl2BioGRID24040135 details
Ezh2Mdm2BioGRID26748827 details
Ezh2Pja1BioGRID28067271 details
Ezh2Ascl1BioGRID20506217 details
Ezh2EzhipBioGRID31281901 details
Ezh2Hdac1BioGRID, IntAct12900441 22439931 details
Ezh2SetxBioGRID, IntAct20064376 details
Ezh2Morc3BioGRID, IntAct20064376 details
Ezh2Rbbp7BioGRID, IntAct20064376 25680957 details
Ezh2Stk38BioGRID, IntAct20064376 details
Ezh2Trim35BioGRID, IntAct20064376 details
Ezh2Dnmt1BioGRID, IntAct22094255 24074865 details
Ezh2Tle1BioGRID, IntAct22439931 details
Ezh2SUZ12MINT23624935 details
Ezh2EEDMINT23624935 details
Ezh2Brca1BioGRID, MINT23624935 details
Ezh2Yy1MINT23531880 details
Ezh2NanogBioGRID, MINT23892456 details
Ezh2Dnmt3bIntAct24074865 details
Ezh2Dnmt3aIntAct24074865 details
Ezh2Trpm7IntAct24855944 details
Ezh2JARID2DIP20075857 details
Ezh2RlimDIP22596162 details
Ezh2PHF1DIP23142980 details
Ezh2Ezh2BioGRID25680957 details
Ezh2DbtBioGRID25680957 details
Ezh2EpopBioGRID25680957 details
Ezh2Ezh1BioGRID25680957 details
Ezh2Ddx27BioGRID25680957 details
Ezh2Noc3lBioGRID25680957 details
Ezh2WizBioGRID25680957 details
Ezh2BckdhbBioGRID25680957 details
Ezh2Ehmt1BioGRID25680957 details
Ezh2Ehmt2BioGRID25680957 details
Ezh2Zfp518aBioGRID25680957 details
Ezh2LcorBioGRID25680957 details
Ezh2Vangl1BioGRID25680957 details
Ezh2Cbx5BioGRID25680957 details
Ezh2H1f0BioGRID25680957 details
Ezh2H1f6BioGRID25680957 details
Ezh2Myo18aBioGRID25680957 details
Ezh2HmmrBioGRID25680957 details
Ezh2ArvcfBioGRID25680957 details
Ezh2Wsb2BioGRID32325033 details
Ezh2Slc25a10BioGRID32325033 details
Ezh2Fbn1IntAct22094255 details
Ezh2Sox17IntAct22094255 details
Ezh2Pax3IntAct22325148 details
Ezh2Hoxa7IntAct22325148 details
Ezh2Cdx2IntAct22325148 details
Ezh2Nkx2-2IntAct22325148 details
Ezh2Msx1IntAct22325148 details
Ezh2Gata4IntAct22325148 details
Ezh2Egr1IntAct22439931 details
Ezh2Atf3IntAct22439931 details
Ezh2Hoxb5IntAct23850221 details
Ezh2Hoxb8IntAct23850221 details
Ezh2Parp12IntAct25417162 details
Ezh2Hoxc12IntAct24955524 25417162 details
Ezh2Spock2IntAct25417162 details
Ezh2Hoxc9IntAct25417162 details
Ezh2Hoxc13IntAct25417162 details
Ezh2Onecut1IntAct25417162 details
Ezh2Hoxd9IntAct25417162 details
Ezh2Hoxd8IntAct25417162 details
Ezh2Hoxd3IntAct25417162 details
Ezh2Hoxd13IntAct25417162 details
Ezh2Hoxd12IntAct25417162 details
Ezh2Evx2IntAct25417162 details
Ezh2Tmem200aIntAct25417162 details
Ezh2Gpr26IntAct25417162 details
Ezh2Hoxd10IntAct25417162 details
Ezh2Hoxd1IntAct25417162 details
Ezh2Foxp3IntAct22896699 details
Ezh2Hoxc11IntAct24955524 details