Entity Details

Primary name Ptk2
Entity type gene
Source Source Link

Details

PrimaryID14083
RefseqGene
SymbolPtk2
NamePTK2 protein tyrosine kinase 2
Chromosome15
Location15 33.94 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-23
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsFAK1_MOUSE

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001725 stress fiber
GO:0001764 neuron migration
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003779 actin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007097 nuclear migration
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007254 JNK cascade
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008432 JUN kinase binding
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010632 regulation of epithelial cell migration
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016604 nuclear body
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030644 cellular chloride ion homeostasis
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0036064 ciliary basal body
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043542 endothelial cell migration
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045667 regulation of osteoblast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050766 positive regulation of phagocytosis
GO:0050771 negative regulation of axonogenesis
GO:0050806 positive regulation of synaptic transmission
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060252 positive regulation of glial cell proliferation
GO:0060396 growth hormone receptor signaling pathway
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090303 positive regulation of wound healing
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0120041 positive regulation of macrophage proliferation
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
Ptk2Bcar1BioGRID, IntAct, MINT18233957 7479864 9038154 details
Ptk2FynBioGRID, IntAct15102471 17875741 details
Ptk2Grb7MINT17318180 details
Ptk2PTPN1MINT9418872 details
Ptk2PXNBioGRID, mbinfo10417825 20150423 details
Ptk2EfsBioGRID9038154 9750131 details
Ptk2EFSBioGRID9750131 details
Ptk2Gata4BioGRID22734001 details
Ptk2Ptk2BioGRID10431817 details
Ptk2SrcBioGRID, MINT10362356 10931187 16966330 18233957 32325033 details
Ptk2PxnBioGRID, IntAct, mbinfo, MINT10931187 15138291 16298995 20308429 21289086 details
Ptk2Ephb2IntAct16298995 details
Ptk2Grb2IntAct, MINT16298995 7997267 details
Ptk2Nrp1MINT18464795 details
Ptk2SRCMINT18464795 9148935 details
Ptk2Ptpn11MINT19698715 details
Ptk2GRB2MINT8816475 9148935 details
Ptk2BCAR1mbinfo20150423 details
Ptk2Actr3mbinfo17721515 details
Ptk2WaslBioGRID, mbinfo17721515 32325033 details
Ptk2Dnm2BioGRID, mbinfo15895076 32325033 details
Ptk2Bcl2BioGRID10417825 details
Ptk2Sorbs1BioGRID9461600 details
Ptk2Socs3BioGRID14517242 details
Ptk2LpxnBioGRID12674328 details
Ptk2Mapk8ip3BioGRID16141199 details
Ptk2Tbk1BioGRID31690171 details
Ptk2Kcnb1BioGRID18615577 details
Ptk2Dlg4BioGRID, IntAct28671696 details
Ptk2Dlgap1BioGRID, IntAct27507650 28671696 details
Ptk2Agap2BioGRID, IntAct28706196 details
Ptk2Hdac4BioGRID, MINT31040226 details
Ptk2Ppp1caBioGRID17274640 details
Ptk2Wdtc1BioGRID27113764 details
Ptk2Tia1BioGRID27160897 details
Ptk2Asap1BioGRID32325033 details
Ptk2Dvl1BioGRID32325033 details
Ptk2Eps8l2BioGRID32325033 details
Ptk2Mical1BioGRID32325033 details
Ptk2Ppp1cbBioGRID32325033 details
Ptk2PtenBioGRID32325033 details
Ptk2Actn1BioGRID32325033 details
Ptk2AmphBioGRID32325033 details
Ptk2Atg12BioGRID32325033 details
Ptk2Ctnnb1BioGRID32325033 details
Ptk2CttnBioGRID32325033 details
Ptk2Dag1BioGRID32325033 details
Ptk2Iqgap1BioGRID32325033 details
Ptk2Pcsk1BioGRID32325033 details
Ptk2EzrBioGRID32325033 details
Ptk2Ncam1BioGRID32325033 details
Ptk2Tln1BioGRID32325033 details
Ptk2Ptk2bBioGRID32325033 details
Ptk2Ptpn23BioGRID32325033 details
Ptk2Tns3BioGRID32325033 details
Ptk2VclBioGRID32325033 details