Entity Details

Primary name MK08_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ91Y86
EntryNameMK08_MOUSE
FullNameMitogen-activated protein kinase 8
TaxID10090
Evidenceevidence at protein level
Length384
SequenceStatuscomplete
DateCreated2002-08-30
DateModified2021-06-02

Ontological Relatives

GenesMapk8

GO terms

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GOName
GO:0001503 ossification
GO:0001764 neuron migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0002102 podosome
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0006970 response to osmotic stress
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009408 response to heat
GO:0009411 response to UV
GO:0009612 response to mechanical stimulus
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019894 kinesin binding
GO:0019899 enzyme binding
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031116 positive regulation of microtubule polymerization
GO:0031175 neuron projection development
GO:0031281 positive regulation of cyclase activity
GO:0031398 positive regulation of protein ubiquitination
GO:0031982 vesicle
GO:0032091 negative regulation of protein binding
GO:0032839 dendrite cytoplasm
GO:0032880 regulation of protein localization
GO:0034198 cellular response to amino acid starvation
GO:0034352 positive regulation of glial cell apoptotic process
GO:0034614 cellular response to reactive oxygen species
GO:0035033 histone deacetylase regulator activity
GO:0035556 intracellular signal transduction
GO:0042542 response to hydrogen peroxide
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043204 perikaryon
GO:0043525 positive regulation of neuron apoptotic process
GO:0045202 synapse
GO:0045664 regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0046605 regulation of centrosome cycle
GO:0046686 response to cadmium ion
GO:0048263 determination of dorsal identity
GO:0048511 rhythmic process
GO:0048813 dendrite morphogenesis
GO:0051247 positive regulation of protein metabolic process
GO:0051403 stress-activated MAPK cascade
GO:0061833 protein localization to tricellular tight junction
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071276 cellular response to cadmium ion
GO:0071732 cellular response to nitric oxide
GO:0071803 positive regulation of podosome assembly
GO:0090045 positive regulation of deacetylase activity
GO:0097050 type B pancreatic cell apoptotic process
GO:0097150 neuronal stem cell population maintenance
GO:0097300 programmed necrotic cell death
GO:0097441 basal dendrite
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901485 positive regulation of transcription factor catabolic process
GO:1902595 regulation of DNA replication origin binding
GO:1904809 regulation of dense core granule transport
GO:2000017 positive regulation of determination of dorsal identity
GO:2001224 positive regulation of neuron migration
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008351 Mitogen-activated protein (MAP) kinase, JNKFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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