Entity Details

Primary name Gclc
Entity type gene
Source Source Link

Details

PrimaryID14629
RefseqGene
SymbolGclc
Nameglutamate-cysteine ligase, catalytic subunit
Chromosome9
Location9 43.36 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-28
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsGSH1_MOUSE

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004357 glutamate-cysteine ligase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0007584 response to nutrient
GO:0009408 response to heat
GO:0009410 response to xenobiotic stimulus
GO:0009725 response to hormone
GO:0014823 response to activity
GO:0016595 glutamate binding
GO:0017109 glutamate-cysteine ligase complex
GO:0019852 L-ascorbic acid metabolic process
GO:0031397 negative regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043531 ADP binding
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044752 response to human chorionic gonadotropin
GO:0044877 protein-containing complex binding
GO:0045454 cell redox homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046685 response to arsenic-containing substance
GO:0046686 response to cadmium ion
GO:0051409 response to nitrosative stress
GO:0051900 regulation of mitochondrial depolarization
GO:0070555 response to interleukin-1
GO:0071260 cellular response to mechanical stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0097069 cellular response to thyroxine stimulus
GO:0097746 blood vessel diameter maintenance
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000490 negative regulation of hepatic stellate cell activation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GclcGclmBioGRID16081425 32325033 details
GclcItga2bBioGRID30333137 details
GclcPpidBioGRID32325033 details