Entity Details

Primary name ARRB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ91YI4
EntryNameARRB2_MOUSE
FullNameBeta-arrestin-2
TaxID10090
Evidenceevidence at protein level
Length410
SequenceStatuscomplete
DateCreated2002-03-05
DateModified2021-06-02

Ontological Relatives

GenesArrb2

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G protein-coupled receptor internalization
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006366 transcription by RNA polymerase II
GO:0006897 endocytosis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0015031 protein transport
GO:0016323 basolateral plasma membrane
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030139 endocytic vesicle
GO:0031397 negative regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031625 ubiquitin protein ligase binding
GO:0031691 alpha-1A adrenergic receptor binding
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031762 follicle-stimulating hormone receptor binding
GO:0031826 type 2A serotonin receptor binding
GO:0031859 platelet activating factor receptor binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 dendritic spine
GO:0043422 protein kinase B binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045211 postsynaptic membrane
GO:0045860 positive regulation of protein kinase activity
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051019 mitogen-activated protein kinase binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071889 14-3-3 protein binding
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1990763 arrestin family protein binding
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000727 positive regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000698 ArrestinFamilyFamily
IPR011021 Arrestin-like, N-terminalDomainDomain
IPR011022 Arrestin C-terminal-like domainDomainDomain
IPR014752 Arrestin-like, C-terminalFamilyHomologous superfamily
IPR014753 Arrestin, N-terminalFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017864 Arrestin, conserved siteSiteConserved site

Diseases

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