Entity Details

Primary name Hdac2
Entity type gene
Source Source Link

Details

PrimaryID15182
RefseqGene
SymbolHdac2
Namehistone deacetylase 2
Chromosome10
Location10 19.44 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsHDAC2_MOUSE

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006325 chromatin organization
GO:0006476 protein deacetylation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016575 histone deacetylation
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcription repressor complex
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0031072 heat shock protein binding
GO:0031490 chromatin DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032732 positive regulation of interleukin-1 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033558 protein deacetylase activity
GO:0034739 histone deacetylase activity (H4-K16 specific)
GO:0035098 ESC/E(Z) complex
GO:0035851 Krueppel-associated box domain binding
GO:0035984 cellular response to trichostatin A
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042733 embryonic digit morphogenesis
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051059 NF-kappaB binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0060789 hair follicle placode formation
GO:0061000 negative regulation of dendritic spine development
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070301 cellular response to hydrogen peroxide
GO:0070734 histone H3-K27 methylation
GO:0070829 heterochromatin maintenance
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:0090571 RNA polymerase II transcription repressor complex
GO:1902437 positive regulation of male mating behavior
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1990841 promoter-specific chromatin binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
Hdac2Anp32aMINT17557114 details
Hdac2Gfi1bBioGRID, UniProt17707228 details
Hdac2Zfp932BioGRID, UniProt21177534 details
Hdac2Six3DIP17666527 details
Hdac2CIR1BioGRID9874765 details
Hdac2THRBBioGRID10508171 details
Hdac2THRABioGRID10508171 details
Hdac2Ctbp1BioGRID20211142 details
Hdac2Hdac9BioGRID20211142 details
Hdac2Pdx1BioGRID15496408 details
Hdac2Cry1BioGRID15226430 details
Hdac2Ddx20BioGRID12007404 details
Hdac2H4f16BioGRID22441348 details
Hdac2Sap30IntAct9702189 details
Hdac2Tal1MINT16407974 details
Hdac2Sin3aBioGRID, DIP, IntAct, MINT15696166 16109738 18454139 19424149 20404188 24240174 details
Hdac2Arid1aBioGRID, MINT17255939 details
Hdac2Sox2BioGRID, IntAct19139101 21103394 details
Hdac2NanogBioGRID, IntAct17093407 18454139 23395962 details
Hdac2Pou5f1BioGRID, IntAct17093407 18454139 20362541 details
Hdac2PRDM1MINT22555612 details
Hdac2Mta2BioGRID, DIP, MINT15920471 18454139 19424149 20404188 24240174 details
Hdac2Foxp3BioGRID, IntAct22922362 26365427 details
Hdac2Rcor2DIP19424149 details
Hdac2Hdac1BioGRID, DIP16109738 19424149 20404188 22297846 details
Hdac2Kdm1aBioGRID, DIP20404188 22297846 26206133 details
Hdac2Smarca4DIP20596014 details
Hdac2Yy1BioGRID17220375 details
Hdac2Tcf7l2BioGRID19503085 details
Hdac2Mbd3BioGRID18454139 details
Hdac2Rbbp7BioGRID18454139 details
Hdac2Sp3BioGRID16109738 details
Hdac2PmlBioGRID18454139 details
Hdac2Gata1BioGRID15920471 details
Hdac2Irs1BioGRID15522123 details
Hdac2Rnf2BioGRID17296600 22496869 details
Hdac2FosbBioGRID21258411 details
Hdac2Spi1BioGRID21518930 details
Hdac2Apex1BioGRID22441348 details
Hdac2Jdp2BioGRID22989952 details
Hdac2Atf3BioGRID22989952 details
Hdac2Smyd1BioGRID11923873 details
Hdac2Tet2BioGRID21490601 details
Hdac2L3mbtl2BioGRID22770845 details
Hdac2Klf5BioGRID18983969 details
Hdac2Lclat1BioGRID26604221 details
Hdac2Chaf1aBioGRID26365490 details
Hdac2SNAI1BioGRID28892081 details
Hdac2Ogg1BioGRID22057269 details
Hdac2Suv39h1MINT11788710 details
Hdac2Mecp2IntAct15696166 details
Hdac2Smarce1IntAct15696166 details
Hdac2Smarcc1IntAct15696166 details
Hdac2Smarcb1IntAct15696166 details
Hdac2Cenpc1MINT21274006 details
Hdac2Sall4BioGRID, IntAct20362541 details
Hdac2Tfcp2l1BioGRID, IntAct20362541 details
Hdac2Mybbp1aBioGRID, MINT22333916 details
Hdac2Rcor1MINT24240174 details
Hdac2Hmga2IntAct26045162 details
Hdac2HopxDIP26113728 details
Hdac2Tbx5bhf-ucl26859351 details
Hdac2Herc2BioGRID, IntAct28671696 details
Hdac2Mycbp2BioGRID, IntAct28671696 details
Hdac2TnikBioGRID, IntAct28671696 details
Hdac2Zfpm1BioGRID, IntAct19654328 details
Hdac2EsrrbBioGRID20362541 details
Hdac2CebpaBioGRID26167872 details
Hdac2Tedc2BioGRID29459677 details
Hdac2Atg16l1BioGRID30196744 details
Hdac2Tfe3BioGRID30595499 details
Hdac2Zbtb7bBioGRID32098917 details
Hdac2Mettl21eBioGRID31162944 details
Hdac2UnkBioGRID25737280 details