Entity Details

Primary name Hdac6
Entity type gene
Source Source Link

Details

PrimaryID15185
RefseqGene
SymbolHdac6
Namehistone deacetylase 6
ChromosomeX
LocationX 3.58 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsHDAC6_MOUSE

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000209 protein polyubiquitination
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003779 actin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005901 caveola
GO:0006476 protein deacetylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006886 intracellular protein transport
GO:0007026 negative regulation of microtubule depolymerization
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0010634 positive regulation of epithelial cell migration
GO:0015630 microtubule cytoskeleton
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016241 regulation of macroautophagy
GO:0016575 histone deacetylation
GO:0019213 deacetylase activity
GO:0030286 dynein complex
GO:0030424 axon
GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 lysosome localization
GO:0032984 protein-containing complex disassembly
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033558 protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035967 cellular response to topologically incorrect protein
GO:0040029 regulation of gene expression, epigenetic
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043005 neuron projection
GO:0043014 alpha-tubulin binding
GO:0043130 ubiquitin binding
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 perikaryon
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0044297 cell body
GO:0045598 regulation of fat cell differentiation
GO:0045861 negative regulation of proteolysis
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0048668 collateral sprouting
GO:0051646 mitochondrion localization
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0051879 Hsp90 protein binding
GO:0060997 dendritic spine morphogenesis
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070201 regulation of establishment of protein localization
GO:0070301 cellular response to hydrogen peroxide
GO:0070840 dynein complex binding
GO:0070842 aggresome assembly
GO:0070845 polyubiquitinated misfolded protein transport
GO:0070846 Hsp90 deacetylation
GO:0070848 response to growth factor
GO:0071218 cellular response to misfolded protein
GO:0090042 tubulin deacetylation
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
GO:2000273 positive regulation of signaling receptor activity

Diseases

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Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
Hdac6UBCMINT11689694 details
Hdac6Tuba1aBioGRID, MINT12486003 19893491 details
Hdac6UbcBioGRID16810319 28190767 details
Hdac6VcpBioGRID, MINT11689694 16810319 details
Hdac6PlaaBioGRID, MINT11689694 32325033 details
Hdac6CyldMINT19893491 details
Hdac6VCPBioGRID, IntAct11689694 26496610 details
Hdac6Myh10DIP25342804 details
Hdac6Septin7BioGRID, IntAct24113571 details
Hdac6Akt1BioGRID, IntAct24955524 details
Hdac6Hdac9IntAct25873389 details
Hdac6MaptBioGRID19457097 details
Hdac6RelaBioGRID12372765 details
Hdac6Nfkb1BioGRID12372765 details
Hdac6Hsp90ab1BioGRID15916966 17785525 22367781 details
Hdac6TARDBPBioGRID23258539 details
Hdac6PrknBioGRID23258539 details
Hdac6Hdac11BioGRID24726361 details
Hdac6Fbxo32BioGRID25516595 details
Hdac6Kat5BioGRID24302573 details
Hdac6Ep400BioGRID24302573 details
Hdac6HDAC6BioGRID, IntAct20360068 details
Hdac6PLAABioGRID, IntAct20360068 26496610 details
Hdac6Rpgrip1lIntAct21565611 details
Hdac6DLATBioGRID, IntAct26496610 details
Hdac6TTC7ABioGRID, IntAct26496610 details
Hdac6BCKDHBBioGRID, IntAct26496610 details
Hdac6OGDHBioGRID, IntAct26496610 details
Hdac6PDHBBioGRID, IntAct26496610 details
Hdac6PDHA1BioGRID, IntAct26496610 details
Hdac6MRPS36BioGRID, IntAct26496610 details
Hdac6IREB2BioGRID, IntAct26496610 details
Hdac6DLSTBioGRID, IntAct26496610 details
Hdac6SRSF3BioGRID, IntAct26496610 details
Hdac6MICALL2BioGRID, IntAct26496610 details
Hdac6BCKDHABioGRID, IntAct26496610 details
Hdac6MKLN1BioGRID, IntAct26496610 details
Hdac6IFIH1BioGRID, IntAct26496610 details
Hdac6PDHXBioGRID, IntAct26496610 details
Hdac6SORBS3BioGRID, IntAct26496610 details
Hdac6DLDBioGRID, IntAct26496610 details
Hdac6KAT6BBioGRID, IntAct26496610 details
Hdac6HPS5BioGRID, IntAct26496610 details
Hdac6USP47BioGRID, IntAct20360068 26496610 details
Hdac6DBTBioGRID, IntAct26496610 details
Hdac6PDK2BioGRID, IntAct26496610 details
Hdac6Nr4a1UniProt19321449 details
Hdac6CDC73MINT29774127 details
Hdac6GARS1BioGRID20360068 details
Hdac6TDGBioGRID26496610 details
Hdac6Wdfy4BioGRID30409884 details
Hdac6Acin1BioGRID32325033 details
Hdac6Bdh1BioGRID32325033 details
Hdac6Ddx19aBioGRID32325033 details
Hdac6Gsk3aBioGRID32325033 details
Hdac6NaspBioGRID32325033 details
Hdac6Rufy3BioGRID32325033 details
Hdac6Ctnnb1BioGRID32325033 details
Hdac6FntaBioGRID32325033 details
Hdac6FntbBioGRID32325033 details
Hdac6Ppa1BioGRID32325033 details
Hdac6Sf3a1BioGRID32325033 details
Hdac6TpppBioGRID32325033 details
Hdac6CfdBioGRID30550785 details
Hdac6Fndc5BioGRID30550785 details
Hdac6Mettl21eBioGRID31162944 details
Hdac6Hoxc12IntAct24955524 details