Entity Details

Primary name Hif1a
Entity type gene
Source Source Link

Details

PrimaryID15251
RefseqGene
SymbolHif1a
Namehypoxia inducible factor 1, alpha subunit
Chromosome12
Location12 31.99 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsHIF1A_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000302 response to reactive oxygen species
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001755 neural crest cell migration
GO:0001837 epithelial to mesenchymal transition
GO:0001892 embryonic placenta development
GO:0001922 B-1 B cell homeostasis
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002039 p53 binding
GO:0002052 positive regulation of neuroblast proliferation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003151 outflow tract morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006089 lactate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0007595 lactation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0010039 response to iron ion
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0014850 response to muscle activity
GO:0016239 positive regulation of macroautophagy
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0019896 axonal transport of mitochondrion
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021502 neural fold elevation formation
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030502 negative regulation of bone mineralization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031514 motile cilium
GO:0031625 ubiquitin protein ligase binding
GO:0032007 negative regulation of TOR signaling
GO:0032364 oxygen homeostasis
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032963 collagen metabolic process
GO:0032991 protein-containing complex
GO:0035035 histone acetyltransferase binding
GO:0035162 embryonic hemopoiesis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042541 hemoglobin biosynthetic process
GO:0042593 glucose homeostasis
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043565 sequence-specific DNA binding
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044877 protein-containing complex binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045906 negative regulation of vasoconstriction
GO:0045926 negative regulation of growth
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046716 muscle cell cellular homeostasis
GO:0046886 positive regulation of hormone biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050790 regulation of catalytic activity
GO:0051216 cartilage development
GO:0051541 elastin metabolic process
GO:0051879 Hsp90 protein binding
GO:0060574 intestinal epithelial cell maturation
GO:0060992 response to fungicide
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061072 iris morphogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101 positive regulation of chemokine-mediated signaling pathway
GO:0070243 regulation of thymocyte apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070888 E-box binding
GO:0071347 cellular response to interleukin-1
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
GO:0098586 cellular response to virus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1903715 regulation of aerobic respiration
GO:1904115 axon cytoplasm
GO:2000273 positive regulation of signaling receptor activity
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000434 regulation of protein neddylation
GO:2001054 negative regulation of mesenchymal cell apoptotic process

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
Hif1aNdnBioGRID, MINT15978586 17826745 details
Hif1aArntBioGRID, DIP, IntAct10873592 20609350 26245371 8816435 details
Hif1aTsga10MINT16777103 details
Hif1aVHLIntAct11292862 details
Hif1aTlx3BioGRID, IntAct20211142 details
Hif1aArntlBioGRID20211142 9704006 details
Hif1aVhlBioGRID11859074 12468553 17981124 20211142 29279301 details
Hif1aCOPS5BioGRID11707426 details
Hif1aTP53BioGRID11707426 details
Hif1aUbe2iBioGRID17981124 details
Hif1aSenp1BioGRID17981124 details
Hif1aSnai1BioGRID21257819 details
Hif1aSumo1MINT15225651 details
Hif1aHDAC4MINT19071119 details
Hif1aHDAC5MINT19071119 details
Hif1aFoxa2IntAct20609350 details
Hif1aEP300IntAct20609350 details
Hif1aRorcIntAct21871655 details
Hif1aRbfox3IntAct21871655 details
Hif1aE2f8MINT22903062 details
Hif1aMycIntAct24360282 details
Hif1aSmad3BioGRID17053163 details
Hif1aEp300BioGRID18268343 details
Hif1aFoxo3BioGRID18268343 details
Hif1aAtf4BioGRID23649506 details
Hif1aEgln2BioGRID23649506 details
Hif1aEgln1BioGRID23649506 details
Hif1aEgln3BioGRID23649506 details
Hif1aHspa1bBioGRID28116619 details
Hif1aHsp90aa1BioGRID28116619 details
Hif1aMtf1BioGRID18337454 details
Hif1aHif3aBioGRID21546903 details
Hif1aVegfaBioGRID21257819 details
Hif1aHdac7BioGRID23853092 details
Hif1aPrkceIntAct11139474 details
Hif1aArnt2IntAct10873592 details
Hif1aHes6IntAct20609350 details
Hif1aStat3IntAct21871655 details
Hif1aIl17aIntAct21871655 details
Hif1aIl17raIntAct21871655 details
Hif1aLdhaIntAct24360282 details
Hif1aMitfBioGRID, MINT15983061 details