Entity Details

Primary name ITB3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO54890
EntryNameITB3_MOUSE
FullNameIntegrin beta-3
TaxID10090
Evidenceevidence at protein level
Length787
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesItgb3

GO terms

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GOName
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0002687 positive regulation of leukocyte migration
GO:0003756 protein disulfide isomerase activity
GO:0005080 protein kinase C binding
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007044 cell-substrate junction assembly
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010763 positive regulation of fibroblast migration
GO:0010888 negative regulation of lipid storage
GO:0014909 smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0031589 cell-substrate adhesion
GO:0032147 activation of protein kinase activity
GO:0032369 negative regulation of lipid transport
GO:0032587 ruffle membrane
GO:0032880 regulation of protein localization
GO:0032956 regulation of actin cytoskeleton organization
GO:0032991 protein-containing complex
GO:0033627 cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033690 positive regulation of osteoblast proliferation
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034679 integrin alpha9-beta1 complex
GO:0034683 integrin alphav-beta3 complex
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045672 positive regulation of osteoclast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045780 positive regulation of bone resorption
GO:0046718 viral entry into host cell
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048858 cell projection morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050839 cell adhesion molecule binding
GO:0050840 extracellular matrix binding
GO:0050919 negative chemotaxis
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051611 regulation of serotonin uptake
GO:0060548 negative regulation of cell death
GO:0061097 regulation of protein tyrosine kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071133 alpha9-beta1 integrin-ADAM8 complex
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:0099699 integral component of synaptic membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1900731 positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:1903053 regulation of extracellular matrix organization
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027068 Integrin beta-3 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
ITB3_MOUSEUBQL2_MOUSEBioGRID10549293 details
ITB3_MOUSEGANAB_MOUSEBioGRID30333137 details
ITB3_MOUSEXPO2_MOUSEBioGRID30333137 details
ITB3_MOUSEHUWE1_MOUSEBioGRID30333137 details
ITB3_MOUSEUBP8_MOUSEBioGRID30333137 details
ITB3_MOUSEXPO1_MOUSEBioGRID30333137 details
ITB3_MOUSEUBR4_MOUSEBioGRID30333137 details
ITB3_MOUSETP53B_MOUSEBioGRID30333137 details
ITB3_MOUSEHCFC1_MOUSEBioGRID30333137 details
ITB3_MOUSEFLNA_MOUSEBioGRID30333137 details
ITB3_MOUSEPDC6I_MOUSEBioGRID30333137 details
ITB3_MOUSEUBA1_MOUSEBioGRID30333137 details
ITB3_MOUSEMOV10_MOUSEBioGRID30333137 details
ITB3_MOUSEFLNC_MOUSEBioGRID30333137 details
ITB3_MOUSEDIAP1_MOUSEBioGRID30333137 details
ITB3_MOUSEMYOF_MOUSEBioGRID30333137 details
ITB3_MOUSEDNSL2_MOUSEBioGRID30333137 details
ITB3_MOUSEPECR_MOUSEBioGRID30333137 details
ITB3_MOUSEGCN1_MOUSEBioGRID30333137 details
ITB3_MOUSEPLEC_MOUSEBioGRID30333137 details
ITB3_MOUSEMA2C1_MOUSEBioGRID30333137 details
ITB3_MOUSESMC2_MOUSEBioGRID30333137 details
ITB3_MOUSEUBP7_MOUSEBioGRID30333137 details
ITB3_MOUSEC1TC_MOUSEBioGRID30333137 details
ITB3_MOUSEMCM4_MOUSEBioGRID30333137 details
ITB3_MOUSEIQGA1_MOUSEBioGRID30333137 details
ITB3_MOUSETLN1_MOUSEBioGRID30333137 details
ITB3_MOUSECOPA_MOUSEBioGRID30333137 details
ITB3_MOUSEOGFR_MOUSEBioGRID30333137 details
ITB3_MOUSEIF4G2_MOUSEBioGRID30333137 details
ITB3_MOUSESON_MOUSEBioGRID30333137 details
ITB3_MOUSEBIRC6_MOUSEBioGRID30333137 details
ITB3_MOUSEITB3_MOUSEBioGRID30333137 details
ITB3_MOUSEMA2B1_MOUSEBioGRID30333137 details
ITB3_MOUSEAP1B1_MOUSEBioGRID30333137 details
ITB3_MOUSESPT5H_MOUSEBioGRID30333137 details
ITB3_MOUSEIF2B1_MOUSEBioGRID30333137 details
ITB3_MOUSEENPL_MOUSEBioGRID30333137 details
ITB3_MOUSENUCL_MOUSEBioGRID30333137 details
ITB3_MOUSEMAP1B_MOUSEBioGRID30333137 details
ITB3_MOUSEAP2A2_MOUSEBioGRID30333137 details
ITB3_MOUSECBL_MOUSEBioGRID30333137 details
ITB3_MOUSEEIF3A_MOUSEBioGRID30333137 details
ITB3_MOUSEDYN2_MOUSEBioGRID30333137 details
ITB3_MOUSEHS74L_MOUSEBioGRID30333137 details
ITB3_MOUSEUSP9X_MOUSEBioGRID30333137 details
ITB3_MOUSEMCM2_MOUSEBioGRID30333137 details
ITB3_MOUSEMCM6_MOUSEBioGRID30333137 details
ITB3_MOUSEPRKDC_MOUSEBioGRID30333137 details
ITB3_MOUSEIF2P_MOUSEBioGRID30333137 details
ITB3_MOUSEPSA_MOUSEBioGRID30333137 details
ITB3_MOUSEATX2L_MOUSEBioGRID30333137 details
ITB3_MOUSEPSMD2_MOUSEBioGRID30333137 details
ITB3_MOUSEPSMD1_MOUSEBioGRID30333137 details
ITB3_MOUSESC24A_MOUSEBioGRID30333137 details
ITB3_MOUSEESYT1_MOUSEBioGRID30333137 details
ITB3_MOUSEMYH10_MOUSEBioGRID30333137 details
ITB3_MOUSEPUR4_MOUSEBioGRID30333137 details
ITB3_MOUSEEWS_MOUSEBioGRID30333137 details
ITB3_MOUSECLH1_MOUSEBioGRID30333137 details
ITB3_MOUSECAPR1_MOUSEBioGRID30333137 details
ITB3_MOUSEHS105_MOUSEBioGRID30333137 details
ITB3_MOUSEKINH_MOUSEBioGRID30333137 details
ITB3_MOUSESPTB2_MOUSEBioGRID30333137 details
ITB3_MOUSEVINC_MOUSEBioGRID30333137 details
ITB3_MOUSENOMO1_MOUSEBioGRID30333137 details
ITB3_MOUSEU520_MOUSEBioGRID30333137 details
ITB3_MOUSEUGGG1_MOUSEBioGRID30333137 details
ITB3_MOUSECAND1_MOUSEBioGRID30333137 details
ITB3_MOUSESYVC_MOUSEBioGRID30333137 details
ITB3_MOUSETPR_MOUSEBioGRID30333137 details
ITB3_MOUSETCPR1_MOUSEBioGRID30333137 details
ITB3_MOUSEFLNB_MOUSEBioGRID30333137 details
ITB3_MOUSESYAC_MOUSEBioGRID30333137 details
ITB3_MOUSEIPO5_MOUSEBioGRID30333137 details
ITB3_MOUSESRRM2_MOUSEBioGRID30333137 details
ITB3_MOUSESYIC_MOUSEBioGRID30333137 details
ITB3_MOUSEIPO11_MOUSEBioGRID30333137 details
ITB3_MOUSESF3A1_MOUSEBioGRID30333137 details
ITB3_MOUSEEIF3C_MOUSEBioGRID30333137 details
ITB3_MOUSEMYH9_MOUSEBioGRID30333137 details
ITB3_MOUSEAT1A1_MOUSEBioGRID30333137 details
ITB3_MOUSEOAS3_MOUSEBioGRID30333137 details
ITB3_MOUSESFPQ_MOUSEBioGRID30333137 details
ITB3_MOUSEPRP8_MOUSEBioGRID30333137 details
ITB3_MOUSEIPO7_MOUSEBioGRID30333137 details
ITB3_MOUSERENT1_MOUSEBioGRID30333137 details
ITB3_MOUSEDYHC1_MOUSEBioGRID30333137 details
ITB3_MOUSECOPB_MOUSEBioGRID30333137 details
ITB3_MOUSEVAV3_MOUSEBioGRID30333137 details
ITB3_MOUSESUCA_MOUSEBioGRID30333137 details
ITB3_MOUSEILF3_MOUSEBioGRID30333137 details
ITB3_MOUSEITA5_MOUSEmbinfo11756480 details
ITB3_MOUSEEGFR_MOUSEDIP17606926 details
ITB3_MOUSESRC_MOUSEDIP18840695 details
ITB3_MOUSEKPCA_MOUSEBioGRID16014375 details
ITB3_MOUSECSK_MOUSEBioGRID24558484 details
ITB3_MOUSEPA24A_MOUSEBioGRID18840708 details
ITB3_MOUSEKPCB_MOUSEBioGRID18840708 details