Entity Details

Primary name Irak1
Entity type gene
Source Source Link

Details

PrimaryID16179
RefseqGene
SymbolIrak1
Nameinterleukin-1 receptor-associated kinase 1
ChromosomeX
LocationX 37.61 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsIRAK1_MOUSE

GO terms

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GOName
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0016020 membrane
GO:0016301 kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031072 heat shock protein binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0090370 negative regulation of cholesterol efflux
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
Irak1Traf6BioGRID, IntAct12566447 15102471 16831874 21460221 details
Irak1Myd88BioGRID, DIP, InnateDB, IntAct10854325 15952741 21441935 21743479 22011580 30108181 31930677 details
Irak1XiapIntAct15102471 details
Irak1Notch2IntAct15102471 details
Irak1Eea1IntAct15102471 details
Irak1ParvgIntAct15102471 details
Irak1LpxnIntAct15102471 details
Irak1MdficIntAct15102471 details
Irak1S100a10IntAct15102471 details
Irak1Ankrd17IntAct15102471 details
Irak1Anxa1IntAct15102471 details
Irak1Dlk1IntAct15102471 details
Irak1Fbln2IntAct15102471 details
Irak1Ech1IntAct15102471 details
Irak1Aarsd1IntAct15102471 details
Irak1Dynlt1fIntAct15102471 details
Irak1Dynlt1cIntAct15102471 details
Irak1Dynlt1aIntAct15102471 details
Irak1Dynlt1bIntAct15102471 details
Irak1Vcpip1IntAct15102471 details
Irak1Dkk3IntAct15102471 details
Irak1Irak4BioGRID19378012 details
Irak1Pin1BioGRID21743479 details
Irak1Peli2BioGRID, IntAct12370331 details
Irak1TifaIntAct12566447 details
Irak1TollipBioGRID, IntAct10854325 19273233 details
Irak1Il1r1BioGRID, IntAct10854325 17507369 details
Irak1PIN1InnateDB21743479 details
Irak1Irf5BioGRID, IntAct18824541 24706909 details
Irak1Traf2IntAct24706909 details
Irak1Spp1IntAct24706909 details
Irak1UbbDIP19815506 details
Irak1UbcDIP19815506 details
Irak1Rps27aDIP19815506 details
Irak1Uba52DIP19815506 details
Irak1Tlr4BioGRID18562480 details
Irak1Tnfrsf1aBioGRID18562480 details
Irak1Il1rapBioGRID18562480 details
Irak1Bcl10BioGRID16831874 details
Irak1Map3k7BioGRID16831874 details
Irak1Irak1BioGRID21460221 details
Irak1Rsad2BioGRID21435586 details
Irak1Rnf41BioGRID19483718 details
Irak1Stat3BioGRID15465816 details
Irak1PrkceBioGRID20044140 details
Irak1Nr0b2BioGRID19104650 details
Irak1Reg1BioGRID22037600 details
Irak1BtrcBioGRID29038250 details
Irak1RNF152BioGRID31930677 details
Irak1DISC1MINT29961565 details
Irak1Il10IntAct24706909 details