Entity Details

Primary name Irs1
Entity type gene
Source Source Link

Details

PrimaryID16367
RefseqGene
SymbolIrs1
Nameinsulin receptor substrate 1
Chromosome1
Location1 42.0 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsIRS1_MOUSE

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016042 lipid catabolic process
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030159 signaling receptor complex adaptor activity
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0031000 response to caffeine
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0034504 protein localization to nucleus
GO:0036064 ciliary basal body
GO:0042169 SH2 domain binding
GO:0042327 positive regulation of phosphorylation
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0070094 positive regulation of glucagon secretion
GO:0071398 cellular response to fatty acid
GO:0090275 negative regulation of somatostatin secretion

Diseases

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Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
Irs1NclMINT9813005 details
Irs1PTPN1MINT10751417 details
Irs1INSRMINT12446583 details
Irs1GRB2IntAct25814554 details
Irs1PIK3R3IntAct25814554 details
Irs1Rps6kb1BioGRID15249583 details
Irs1CrkBioGRID9729467 details
Irs1Fbxo40BioGRID22033112 details
Irs1Igf1rBioGRID22033112 details
Irs1VimBioGRID, IntAct15602769 26773517 details
Irs1Pik3r1BioGRID, MINT12783867 14684612 14966267 15169905 15183122 15249583 15380067 16455755 18059474 18296638 20804756 27708159 8557661 details
Irs1Trp53bp2IntAct17965023 details
Irs1TP53BP2IntAct17965023 details
Irs1Eif2ak2IntAct20144759 details
Irs1YwhaeBioGRID, MINT16216880 16944949 details
Irs1YwhabMINT11875115 9422753 details
Irs1Sirt1UniProt17901049 details
Irs1IGF1RMINT22261717 details
Irs1Mapk8DIP16818881 details
Irs1Mapk9DIP16818881 details
Irs1Trim72DIP23354051 details
Irs1UbbDIP23354051 details
Irs1UbcDIP23354051 details
Irs1Rps27aDIP23354051 details
Irs1Uba52DIP23354051 details
Irs1Shc1IntAct11259577 details
Irs1Grb2IntAct11259577 details
Irs1Hdac2BioGRID15522123 details
Irs1InsrBioGRID15249583 details
Irs1Irs2BioGRID9729467 details
Irs1Rbx1BioGRID22033112 details
Irs1Pik3caBioGRID27708159 details
Irs1Usp7BioGRID27568561 details
Irs1PtenBioGRID27568561 details
Irs1PrkczBioGRID26773517 details
Irs1Sqstm1BioGRID26773517 details
Irs1Rad51BioGRID15965906 details
Irs1Trp53BioGRID30578299 details
Irs1Grin1IntAct16635246 details
Irs1Grin2bIntAct16635246 details
Irs1Hsp90ab1IntAct15602769 details
Irs1Rps3IntAct15602769 details
Irs1Epha2IntAct15602769 details
Irs1YwhagIntAct15602769 details
Irs1Ipo8IntAct15602769 details
Irs1Flot2IntAct15602769 details
Irs1RanIntAct15602769 details
Irs1Poldip3IntAct15602769 details
Irs1Rfc3IntAct15602769 details
Irs1H1f0IntAct15602769 details
Irs1HnrnpuIntAct15602769 details
Irs1Ybx1IntAct15602769 details
Irs1Ppp2r1aIntAct15602769 details
Irs1Rab6bIntAct15602769 details
Irs1RarsIntAct15602769 details
Irs1PhbIntAct15602769 details
Irs1Ctnnb1IntAct15602769 details
Irs1Cnot9IntAct15602769 details
Irs1UngIntAct15602769 details
Irs1Ppfibp1IntAct15602769 details
Irs1Rpn2IntAct15602769 details
Irs1Hspa8IntAct15602769 details
Irs1Cand1IntAct15602769 details
Irs1Rplp0IntAct15602769 details
Irs1Cavin2IntAct15602769 details
Irs1Snd1IntAct15602769 details
Irs1Ctnnd1IntAct15602769 details
Irs1CfdBioGRID30550785 details
Irs1Fndc5BioGRID30550785 details