Entity Details

Primary name Jak2
Entity type gene
Source Source Link

Details

PrimaryID16452
RefseqGene
SymbolJak2
NameJanus kinase 2
Chromosome19
Location19 23.73 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-19
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsJAK2_MOUSE

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0000791 euchromatin
GO:0001774 microglial cell activation
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755 hormone-mediated signaling pathway
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0012505 endomembrane system
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030099 myeloid cell differentiation
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031103 axon regeneration
GO:0031702 type 1 angiotensin receptor binding
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033130 acetylcholine receptor binding
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034050 programmed cell death induced by symbiont
GO:0034612 response to tumor necrosis factor
GO:0035166 post-embryonic hemopoiesis
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0035409 histone H3-Y41 phosphorylation
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0036016 cellular response to interleukin-3
GO:0042169 SH2 domain binding
GO:0042307 positive regulation of protein import into nucleus
GO:0042393 histone binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042976 activation of Janus kinase activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0045121 membrane raft
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046677 response to antibiotic
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0050867 positive regulation of cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051428 peptide hormone receptor binding
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060399 positive regulation of growth hormone receptor signaling pathway
GO:0060548 negative regulation of cell death
GO:0061180 mammary gland epithelium development
GO:0070671 response to interleukin-12
GO:0071222 cellular response to lipopolysaccharide
GO:0071549 cellular response to dexamethasone stimulus
GO:0097012 response to granulocyte macrophage colony-stimulating factor
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000273 positive regulation of signaling receptor activity
GO:2001235 positive regulation of apoptotic signaling pathway

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
Jak2PtprcMINT11201744 details
Jak2StamMINT9133424 details
Jak2Pck1IntAct15102471 details
Jak2Sh2b1BioGRID, MINT15121872 16824542 32325033 details
Jak2Jak2BioGRID, MINT17290288 23454976 9363897 details
Jak2PRKCAMINT17290288 details
Jak2PTPN1MINT17128263 details
Jak2Socs1BioGRID, MINT10064597 10679268 details
Jak2CDKN1BI2D21423214 details
Jak2Il6stBioGRID, DIP23454976 32325033 details
Jak2Socs3BioGRID, DIP15143188 23454976 details
Jak2DNAJA3BioGRID11679576 details
Jak2Stat3BioGRID15143188 21102457 22402124 details
Jak2EgfrBioGRID9038232 9363897 details
Jak2EIF2AK2BioGRID17290288 details
Jak2STAT1BioGRID7657660 details
Jak2Stat5bBioGRID12456798 details
Jak2Socs5BioGRID23990909 details
Jak2Ubash3bBioGRID12370296 details
Jak2SirpaBioGRID9507023 details
Jak2SHC1MINT7535773 details
Jak2EporMINT17024180 21362419 details
Jak2Csf2rbIntAct18692472 details
Jak2Ptpn11MINT17027227 details
Jak2Cdkn1bBioGRID, I2D21423214 details
Jak2Fcer1gInnateDB24608040 details
Jak2IL23RIntAct12023369 details
Jak2Slc40a1DIP19234114 details
Jak2Crlf2BioGRID, DIP10872831 20974963 details
Jak2LeprBioGRID, DIP21264353 32325033 details
Jak2KitBioGRID8611693 details
Jak2S1pr1BioGRID21102457 details
Jak2SrcBioGRID21102457 details
Jak2Stat5aBioGRID22402124 details
Jak2Pik3r1BioGRID22402124 8702385 details
Jak2Il12rb2BioGRID9038232 details
Jak2Pkd1BioGRID12007403 details
Jak2Cav1BioGRID12388746 details
Jak2Il3raBioGRID15988755 details
Jak2Csf2rb2BioGRID15988755 details
Jak2PrlrBioGRID32325033 9247268 details
Jak2MplBioGRID10918061 7534285 details
Jak2Ptpn1BioGRID11970898 details
Jak2Ifngr1BioGRID32325033 7499845 details
Jak2Yes1BioGRID8702385 details
Jak2Lmo4BioGRID15677447 details
Jak2Ptpn6BioGRID9111009 details
Jak2Csf1IntAct16267818 details
Jak2ElocDIP23454976 details
Jak2ELOBDIP23454976 details
Jak2Sh2b3BioGRID30755420 details
Jak2Tbc1d31BioGRID32325033 details