Entity Details

Primary name Lck
Entity type gene
Source Source Link

Details

PrimaryID16818
RefseqGene
SymbolLck
Namelymphocyte protein tyrosine kinase
Chromosome4
Location4 63.26 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsLCK_MOUSE

GO terms

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GOName
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0003823 antigen binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008022 protein C-terminus binding
GO:0009612 response to mechanical stimulus
GO:0010038 response to metal ion
GO:0010628 positive regulation of gene expression
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030139 endocytic vesicle
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0042169 SH2 domain binding
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042542 response to hydrogen peroxide
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045589 regulation of regulatory T cell differentiation
GO:0046777 protein autophosphorylation
GO:0050853 B cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1990405 protein antigen binding
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
LckCd4BioGRID, IntAct10358158 24034254 7486703 7664803 details
LckCd8aIntAct24034254 7664803 details
LckSh2d2aIntAct10553045 details
LckPtprcIntAct, MINT8570203 9581568 details
LckHcls1IntAct, MINT10713104 7628441 details
LckSocs6BioGRID20007709 details
LckPik3r1BioGRID9115297 details
LckStap1BioGRID10679268 details
LckCblbBioGRID26416283 details
LckPTPRCIntAct8576115 details
LckSH2D2AIntAct10553045 details
LckKHDRBS1IntAct9045636 details
LckSkap2MINT12681493 details
LckFybMINT12681493 details
LckCBLMINT11741956 details
LckEGFRMINT9153411 details
LckStk11MINT21487392 details
LckCblBioGRID11741956 8551236 9115297 details
LckCd38BioGRID10636863 details
LckZap70BioGRID15699074 16501569 details
LckCyldBioGRID16501569 details
LckDlg1BioGRID15699074 details
LckWasBioGRID15699074 details
LckCD4BioGRID1835265 details
LckPtprcapIntAct10318863 details
LckPrkceIntAct11139474 details
LckCd44MINT11369760 details
LckZBED8BioGRID, IntAct26496610 details
LckSPASTBioGRID, IntAct26496610 details
LckCDK13BioGRID, IntAct26496610 details
LckHPS5BioGRID, IntAct26496610 details
LckAPOEBioGRID, IntAct26496610 details
LckYES1BioGRID, IntAct26496610 details
LckNELFCDBioGRID, IntAct26496610 details
LckPHF5ABioGRID, IntAct26496610 details
LckCAMSAP2BioGRID, IntAct26496610 details
LckESCO1BioGRID, IntAct26496610 details
LckNSMCE2BioGRID, IntAct26496610 details
LckMEN1BioGRID, IntAct26496610 details
LckC2CD5BioGRID, IntAct26496610 details
LckATP5MEBioGRID, IntAct26496610 details
LckPag1IntAct26512138 details
LckLCKBioGRID20360068 details
LckTLE5BioGRID26496610 details
LckFancd2BioGRID28378742 details
LckMTNR1BBioGRID18448421 details