Entity Details

Primary name Ldlr
Entity type gene
Source Source Link

Details

PrimaryID16835
RefseqGene
SymbolLdlr
Namelow density lipoprotein receptor
Chromosome9
Location9 7.87 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsLDLR_MOUSE

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002020 protease binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007616 long-term memory
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010898 positive regulation of triglyceride catabolic process
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0034362 low-density lipoprotein particle
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0036477 somatodendritic compartment
GO:0042157 lipoprotein metabolic process
GO:0042159 lipoprotein catabolic process
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0048844 artery morphogenesis
GO:0050729 positive regulation of inflammatory response
GO:0051246 regulation of protein metabolic process
GO:0051248 negative regulation of protein metabolic process
GO:0055038 recycling endosome membrane
GO:0061771 response to caloric restriction
GO:0061889 negative regulation of astrocyte activation
GO:0070508 cholesterol import
GO:0071398 cellular response to fatty acid
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0090181 regulation of cholesterol metabolic process
GO:0097242 amyloid-beta clearance
GO:0097443 sorting endosome
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1903979 negative regulation of microglial cell activation
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:1905907 negative regulation of amyloid fibril formation
GO:1990666 PCSK9-LDLR complex

Diseases

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Interactions

7 interactions

InteractorPartnerSourcesPublicationsLink
LdlrDab1BioGRID, IntAct10380922 10827173 details
LdlrFlt1BioGRID, MINT17962812 details
LdlrMylipBioGRID32325033 details
LdlrNgly1BioGRID32325033 details
LdlrPdia5BioGRID32325033 details
LdlrTmem38bBioGRID32325033 details
LdlrVldlrBioGRID32325033 details