Entity Details

Primary name Smad3
Entity type gene
Source Source Link

Details

PrimaryID17127
RefseqGene
SymbolSmad3
NameSMAD family member 3
Chromosome9
Location9
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-19
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSMAD3_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001947 heart looping
GO:0002076 osteoblast development
GO:0002520 immune system development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0010628 positive regulation of gene expression
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0017151 DEAD/H-box RNA helicase binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030878 thyroid gland development
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0031962 mineralocorticoid receptor binding
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0032924 activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033689 negative regulation of osteoblast proliferation
GO:0035259 glucocorticoid receptor binding
GO:0038092 nodal signaling pathway
GO:0042110 T cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0043235 receptor complex
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0045216 cell-cell junction organization
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0050821 protein stabilization
GO:0050927 positive regulation of positive chemotaxis
GO:0051098 regulation of binding
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060039 pericardium development
GO:0060290 transdifferentiation
GO:0060395 SMAD protein signal transduction
GO:0061045 negative regulation of wound healing
GO:0061767 negative regulation of lung blood pressure
GO:0070306 lens fiber cell differentiation
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901203 positive regulation of extracellular matrix assembly
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress

Diseases

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Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
Smad3Smad4BioGRID, DIP, IntAct, MINT12145309 12672795 14764653 17226765 18268325 21145499 22036565 22045334 22442258 details
Smad3Myod1BioGRID, IntAct11711431 20211142 22036565 details
Smad3Foxh1BioGRID20211142 details
Smad3VdrBioGRID20211142 details
Smad3Gata4BioGRID14662776 details
Smad3JunBioGRID22610349 details
Smad3Magi2BioGRID10681527 details
Smad3ErbinMINT12650946 details
Smad3AXIN1MINT16601693 details
Smad3Axin1BioGRID, MINT16601693 details
Smad3Smad7BioGRID, IntAct19914168 22036565 30315770 details
Smad3Pou5f1IntAct22036565 details
Smad3UBCMINT22045334 details
Smad3Col1a1BioGRID, IntAct14559231 27728806 details
Smad3Gsk3bBioGRID18172167 details
Smad3Snai1BioGRID19597490 details
Smad3Hif1aBioGRID17053163 details
Smad3Pex6BioGRID14651998 details
Smad3Eif4enif1BioGRID14651998 details
Smad3Zmym2BioGRID14651998 details
Smad3Pbx1BioGRID14764653 details
Smad3Pknox1BioGRID14764653 details
Smad3Col3a1BioGRID14559231 details
Smad3Col5a1BioGRID14559231 details
Smad3Yap1BioGRID21145499 details
Smad3Otub1BioGRID24071738 details
Smad3Tgfb1i1BioGRID14755691 details
Smad3CyldBioGRID30315770 details
Smad3TP53IntAct19345189 details
Smad3AHSGBioGRID, IntAct20360068 details
Smad3SMAD3BioGRID, IntAct15761153 20360068 details
Smad3LEMD3BioGRID, IntAct20360068 26496610 details
Smad3Spi1IntAct22036565 details
Smad3Smad2IntAct22442258 details
Smad3PPIL2BioGRID, IntAct26496610 details
Smad3FUBP1BioGRID, IntAct26496610 details
Smad3PRCPBioGRID, IntAct26496610 details
Smad3EIF4BBioGRID, IntAct26496610 details
Smad3EIF4ENIF1BioGRID, IntAct26496610 details
Smad3UBL4ABioGRID, IntAct26496610 details
Smad3STXBP2BioGRID, IntAct26496610 details
Smad3ZFYVE9BioGRID, IntAct26496610 details
Smad3ASCC1BioGRID, IntAct26496610 details
Smad3RBM4BioGRID, IntAct26496610 details
Smad3IP6K3BioGRID, IntAct26496610 details
Smad3GAS2L1BioGRID, IntAct26496610 details
Smad3DOCK6BioGRID, IntAct26496610 details
Smad3WDR75BioGRID, IntAct26496610 details
Smad3BAG6BioGRID, IntAct26496610 details
Smad3TBX3BioGRID, IntAct26496610 details
Smad3HTTBioGRID, IntAct26496610 details
Smad3DHX16BioGRID, IntAct26496610 details
Smad3P3H1BioGRID, IntAct26496610 details
Smad3POLR2GBioGRID, IntAct26496610 details
Smad3GPALPP1BioGRID, IntAct26496610 details
Smad3SLC39A10BioGRID, IntAct26496610 details
Smad3WWP1BioGRID, IntAct26496610 details
Smad3COL5A1BioGRID, IntAct26496610 details
Smad3TAF7BioGRID, IntAct26496610 details
Smad3ROCK1BioGRID, IntAct26496610 details
Smad3GDI2BioGRID, IntAct26496610 details
Smad3GMDSBioGRID, IntAct26496610 details
Smad3IQSEC2BioGRID, IntAct26496610 details
Smad3Xpo7IntAct29748336 unassigned1673 details
Smad3SMAD2BioGRID15761153 details
Smad3SMAD4BioGRID15761153 details
Smad3SMURF1BioGRID15761153 details
Smad3SMURF2BioGRID15761153 details
Smad3ANXA7BioGRID26496610 details
Smad3RBBP6BioGRID26496610 details
Smad3STX18BioGRID26496610 details
Smad3TBC1D10ABioGRID26496610 details
Smad3Atg16l1BioGRID30196744 details
Smad3Lefty1IntAct22036565 details
Smad3Lefty2IntAct22036565 details
Smad3NodalIntAct22036565 details
Smad3Il2raIntAct16087671 22036565 details
Smad3JundIntAct22036565 details
Smad3Rag2IntAct22036565 details
Smad3Vpreb2IntAct22036565 details
Smad3Arid3aIntAct22036565 details
Smad3Adora1IntAct22036565 details
Smad3Id3IntAct22036565 details
Smad3Mef2dIntAct22036565 details
Smad3CkmIntAct22036565 details
Smad3MaxIntAct22036565 details
Smad3PnmtIntAct22036565 details
Smad3Id2IntAct22036565 details
Smad3JunbIntAct22036565 details
Smad3DesIntAct22036565 details
Smad3Foxp3IntAct18157133 20064450 20870174 22908322 23243069 26365427 details
Smad3Lgals9IntAct25065622 details
Smad3Foxo3IntAct25065622 details
Smad3Il9IntAct26365427 details
Smad3Acta2IntAct27728806 details