Entity Details

Primary name Mdm2
Entity type gene
Source Source Link

Details

PrimaryID17246
RefseqGene
SymbolMdm2
Nametransformed mouse 3T3 cell double minute 2
Chromosome10
Location10 66.32 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsMDM2_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001568 blood vessel development
GO:0001974 blood vessel remodeling
GO:0002027 regulation of heart rate
GO:0002039 p53 binding
GO:0003170 heart valve development
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 traversing start control point of mitotic cell cycle
GO:0007507 heart development
GO:0008097 5S rRNA binding
GO:0008270 zinc ion binding
GO:0009636 response to toxic substance
GO:0010039 response to iron ion
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010955 negative regulation of protein processing
GO:0010977 negative regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0016874 ligase activity
GO:0019789 SUMO transferase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032991 protein-containing complex
GO:0033612 receptor serine/threonine kinase binding
GO:0034504 protein localization to nucleus
GO:0042176 regulation of protein catabolic process
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043278 response to morphine
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045472 response to ether
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046827 positive regulation of protein export from nucleus
GO:0047485 protein N-terminus binding
GO:0048545 response to steroid hormone
GO:0051149 positive regulation of muscle cell differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0051865 protein autoubiquitination
GO:0060411 cardiac septum morphogenesis
GO:0061630 ubiquitin protein ligase activity
GO:0061663 NEDD8 ligase activity
GO:0065003 protein-containing complex assembly
GO:0070301 cellular response to hydrogen peroxide
GO:0071301 cellular response to vitamin B1
GO:0071312 cellular response to alkaloid
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071480 cellular response to gamma radiation
GO:0071494 cellular response to UV-C
GO:0072717 cellular response to actinomycin D
GO:0097718 disordered domain specific binding
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904404 response to formaldehyde
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990000 amyloid fibril formation
GO:1990785 response to water-immersion restraint stress

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
Mdm2Arrb1IntAct15102471 details
Mdm2Trp53BioGRID, DIP, I2D, IntAct10205143 10706102 10982879 11953423 14555661 17086174 17936560 18309296 18359851 18566590 18695251 19556538 20697359 20818388 20832751 21183956 21738215 21857681 22216266 22666487 22805162 23580573 25117711 25732823 30545932 30578299 8058315 9732264 details
Mdm2Rassf1BioGRID, MINT18566590 details
Mdm2TP53BioGRID, MINT10202144 11983168 18566590 24980433 details
Mdm2PLK1BioGRID, MINT19833129 details
Mdm2Mdm4BioGRID, DIP, I2D, IntAct17616658 19573810 20697359 21730132 22666487 25117711 25981963 details
Mdm2Cdkn2aBioGRID, IntAct10713175 15485902 20832751 22378045 23580573 details
Mdm2Rassf5MINT22173032 details
Mdm2Mdm2BioGRID17086174 18566590 details
Mdm2Pax3BioGRID22216266 details
Mdm2Senp2BioGRID21183956 details
Mdm2Ube2iBioGRID21183956 details
Mdm2NUMBBioGRID9632782 details
Mdm2POLEBioGRID10982879 details
Mdm2PoleBioGRID10982879 details
Mdm2Ccng1BioGRID11983168 details
Mdm2CDK2BioGRID11983168 details
Mdm2PPP2CABioGRID11983168 details
Mdm2Ube2d3BioGRID22216266 details
Mdm2Ube2d1BioGRID21183956 details
Mdm2CebpbBioGRID25720496 details
Mdm2Ppp2caBioGRID28025327 details
Mdm2Rpl5IntAct17936560 20832751 22789538 details
Mdm2Rpl11BioGRID, IntAct15989966 17936560 20832751 22789538 details
Mdm2UbbDIP, IntAct17936560 21730132 details
Mdm2UbcDIP, IntAct17936560 21730132 details
Mdm2Rps27aDIP, IntAct17936560 21730132 details
Mdm2Uba52DIP, IntAct17936560 21730132 details
Mdm2DaxxBioGRID, MINT15364927 18566590 details
Mdm2YwhaqMINT20086099 details
Mdm2Rpl23BioGRID, IntAct20832751 details
Mdm2Rps6kb1MINT20657550 details
Mdm2USP7BioGRID, I2D20697359 29581288 details
Mdm2Hipk1BioGRID, MINT22173032 details
Mdm2Dlg4BioGRID, IntAct21849563 23260144 30292394 details
Mdm2Eef1a1IntAct23260144 details
Mdm2Sumo1DIP19090619 details
Mdm2Trp73DIP20921405 details
Mdm2RB1DIP7791904 details
Mdm2Hdac1MINT29950602 details
Mdm2Foxo3BioGRID22094330 details
Mdm2Usp7BioGRID18566590 20697359 details
Mdm2ARRB2BioGRID19372219 details
Mdm2Igf1rBioGRID15878855 details
Mdm2NbnBioGRID15734743 details
Mdm2Mre11aBioGRID15734743 details
Mdm2Grk2BioGRID21081496 details
Mdm2Elavl1BioGRID22095636 details
Mdm2Gsk3bBioGRID21738215 details
Mdm2NdnBioGRID22905258 details
Mdm2Ccar1BioGRID22905258 details
Mdm2Eid1BioGRID24167073 details
Mdm2Arrb2BioGRID11588219 details
Mdm2DDX24BioGRID24980433 details
Mdm2Ezh2BioGRID26748827 details
Mdm2Sp1BioGRID22378045 details
Mdm2Dlg2BioGRID30292394 details
Mdm2IRS1BioGRID30578299 details
Mdm2HMGB1BioGRID24980433 details
Mdm2HMGB2BioGRID24980433 details
Mdm2XRCC5BioGRID24980433 details
Mdm2RPL11BioGRID24980433 details
Mdm2RPL3BioGRID24980433 details
Mdm2RPL9BioGRID24980433 details
Mdm2RPS10BioGRID24980433 details
Mdm2RPS14BioGRID24980433 details
Mdm2RPS19BioGRID24980433 details
Mdm2RPS2BioGRID24980433 details
Mdm2RPS25BioGRID24980433 details
Mdm2RPS3ABioGRID24980433 details
Mdm2RPS6BioGRID24980433 details
Mdm2RPS7BioGRID24980433 details
Mdm2RPS9BioGRID24980433 details
Mdm2WDR77BioGRID24980433 details
Mdm2HNRNPFBioGRID24980433 details
Mdm2HNRNPH1BioGRID24980433 details
Mdm2HNRNPKBioGRID24980433 details
Mdm2RBM10BioGRID24980433 details
Mdm2SNRNP200BioGRID24980433 details
Mdm2GRWD1BioGRID24980433 details
Mdm2NCLBioGRID24980433 details
Mdm2TRMT10CBioGRID24980433 details
Mdm2CCT2BioGRID24980433 details
Mdm2CCT4BioGRID24980433 details
Mdm2CCT5BioGRID24980433 details
Mdm2PSMC2BioGRID24980433 details
Mdm2TCP1BioGRID24980433 details
Mdm2HADHABioGRID24980433 details
Mdm2NPM1BioGRID24980433 details
Mdm2YWHABBioGRID24980433 details
Mdm2YWHAQBioGRID24980433 details
Mdm2CDK9BioGRID24980433 details
Mdm2STK38BioGRID24980433 details
Mdm2STK38LBioGRID24980433 details
Mdm2PIP4K2CBioGRID24980433 details
Mdm2TRIM21BioGRID24980433 details
Mdm2THRAP3BioGRID24980433 details
Mdm2EZRBioGRID24980433 details
Mdm2Wdtc1BioGRID27113764 details