Entity Details

Primary name Mecp2
Entity type gene
Source Source Link

Details

PrimaryID17257
RefseqGene
SymbolMecp2
Namemethyl CpG binding protein 2
ChromosomeX
LocationX 37.63 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsMECP2_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000400 four-way junction DNA binding
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001964 startle response
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006020 inositol metabolic process
GO:0006342 chromatin silencing
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006541 glutamine metabolic process
GO:0006576 cellular biogenic amine metabolic process
GO:0006641 triglyceride metabolic process
GO:0007052 mitotic spindle organization
GO:0007268 chemical synaptic transmission
GO:0007416 synapse assembly
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008211 glucocorticoid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008327 methyl-CpG binding
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009791 post-embryonic development
GO:0010385 double-stranded methylated DNA binding
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016358 dendrite development
GO:0016525 negative regulation of angiogenesis
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0019230 proprioception
GO:0019233 sensory perception of pain
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0021549 cerebellum development
GO:0021591 ventricular system development
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0031490 chromatin DNA binding
GO:0031915 positive regulation of synaptic plasticity
GO:0032048 cardiolipin metabolic process
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0033555 multicellular organismal response to stress
GO:0035176 social behavior
GO:0035197 siRNA binding
GO:0035865 cellular response to potassium ion
GO:0040029 regulation of gene expression, epigenetic
GO:0042220 response to cocaine
GO:0042551 neuron maturation
GO:0042826 histone deacetylase binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0044030 regulation of DNA methylation
GO:0045322 unmethylated CpG binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046470 phosphatidylcholine metabolic process
GO:0047485 protein N-terminus binding
GO:0048167 regulation of synaptic plasticity
GO:0048712 negative regulation of astrocyte differentiation
GO:0050807 regulation of synapse organization
GO:0050884 neuromuscular process controlling posture
GO:0050905 neuromuscular process
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051570 regulation of histone H3-K9 methylation
GO:0051707 response to other organism
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0060999 positive regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:0071317 cellular response to isoquinoline alkaloid
GO:0090063 positive regulation of microtubule nucleation
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:1900114 positive regulation of histone H3-K9 trimethylation
GO:1901953 positive regulation of anterograde dense core granule transport
GO:1901956 positive regulation of retrograde dense core granule transport
GO:1903860 negative regulation of dendrite extension
GO:1903861 positive regulation of dendrite extension
GO:1905492 positive regulation of branching morphogenesis of a nerve
GO:1905643 positive regulation of DNA methylation
GO:1990841 promoter-specific chromatin binding
GO:2000635 negative regulation of primary miRNA processing
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
Mecp2Hmgb1MINT11748221 details
Mecp2AtrxBioGRID, DIP, MINT, UniProt17296936 20159591 24270455 details
Mecp2Ewsr1BioGRID, IntAct20211142 details
Mecp2Ep300BioGRID22677942 details
Mecp2Smc3BioGRID, UniProt20159591 details
Mecp2Smc1aBioGRID, UniProt20159591 details
Mecp2Sin3aBioGRID, DIP, MINT19602036 22119903 23770565 details
Mecp2Foxg1MINT22357867 details
Mecp2Smarca4MINT19602036 24270455 details
Mecp2Dnmt3aMINT30102379 details
Mecp2Sp1MINT20385708 details
Mecp2Sp3MINT20385708 details
Mecp2Prmt6BioGRID21497756 details
Mecp2Sirt1BioGRID22677942 details
Mecp2Hdac1BioGRID22119903 details
Mecp2Creb1BioGRID18511691 details
Mecp2Hdac2IntAct15696166 details
Mecp2Smarce1IntAct15696166 details
Mecp2Tbl1xr1DIP23770565 details
Mecp2Tbx5bhf-ucl26859351 details
Mecp2Srrm2MINT24270455 details
Mecp2Rbbp6MINT24270455 details
Mecp2Hnrnpa3MINT24270455 details
Mecp2Hnrnpa2b1MINT24270455 details
Mecp2NclMINT24270455 details
Mecp2Eftud2MINT24270455 details
Mecp2Kdm5cMINT24270455 details
Mecp2Cdk5rap1MINT24270455 details
Mecp2Acin1MINT24270455 details
Mecp2Top3bMINT24270455 details
Mecp2Top1MINT24270455 details
Mecp2SfpqMINT24270455 details
Mecp2RoraMINT24270455 details
Mecp2Prpf8MINT24270455 details
Mecp2NeflMINT24270455 details
Mecp2Myef2MINT24270455 details
Mecp2Jade3MINT24270455 details
Mecp2HnrnpuMINT24270455 details
Mecp2HnrnpmMINT24270455 details
Mecp2Hap1MINT24270455 details
Mecp2Dhx9MINT24270455 details
Mecp2Ddx3xMINT24270455 details
Mecp2Ddx17MINT24270455 details
Mecp2Smarca2MINT24270455 details
Mecp2Satb2MINT30726206 details
Mecp2Dnmt1BioGRID32325033 details
Mecp2Sin3bBioGRID32325033 details
Mecp2CfdBioGRID30550785 details
Mecp2Fndc5BioGRID30550785 details
Mecp2Foxp3IntAct17591856 19109157 details