Entity Details

Primary name NEK8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ91ZR4
EntryNameNEK8_MOUSE
FullNameSerine/threonine-protein kinase Nek8
TaxID10090
Evidenceevidence at protein level
Length698
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesNek8

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005929 cilium
GO:0007059 chromosome segregation
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0009887 animal organ morphogenesis
GO:0035330 regulation of hippo signaling
GO:0046872 metal ion binding
GO:0097543 ciliary inversin compartment
GO:0097546 ciliary base
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000408 Regulator of chromosome condensation, RCC1RepeatRepeat
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IIFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044120 Nek8, catalytic domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NEK8_MOUSEACVR1_HUMANMINT15761153 details
NEK8_MOUSEINVS_MOUSEIntAct, MINT21565611 22687244 details