Entity Details

Primary name Myd88
Entity type gene
Source Source Link

Details

PrimaryID17874
RefseqGene
SymbolMyd88
Namemyeloid differentiation primary response gene 88
Chromosome9
Location9 71.33 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsMYD88_MOUSE

GO terms

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GOName
GO:0002238 response to molecule of fungal origin
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002283 neutrophil activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005102 signaling receptor binding
GO:0005121 Toll binding
GO:0005149 interleukin-1 receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0009615 response to virus
GO:0009682 induced systemic resistance
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016064 immunoglobulin mediated immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0035325 Toll-like receptor binding
GO:0042127 regulation of cell population proliferation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0070944 neutrophil-mediated killing of bacterium
GO:0070976 TIR domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090557 establishment of endothelial intestinal barrier
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902622 regulation of neutrophil migration
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
Myd88Irak1BioGRID, DIP, InnateDB, IntAct10854325 15952741 21441935 21743479 22011580 30108181 31930677 details
Myd88Lrrc59IntAct15102471 details
Myd88Myd88BioGRID, IntAct15102471 30108181 details
Myd88Ube2iIntAct15102471 details
Myd88PIK3R1MINT23247210 details
Myd88Tlr4BioGRID, InnateDB, UniProt17618294 18772134 19378012 19898473 23023391 29990310 details
Myd88Irak4BioGRID, DIP, IntAct16306937 19378012 22011580 24529375 30108181 details
Myd88Traf3BioGRID, DIP16306937 19898473 22011580 details
Myd88Traf6BioGRID, DIP16306937 19898473 22011580 30108181 31268348 details
Myd88Irf1DIP17018642 details
Myd88Irf5DIP17018642 details
Myd88Irf7DIP17018642 details
Myd88TirapBioGRID19378012 30108181 details
Myd88Birc3BioGRID19898473 details
Myd88Rnf41BioGRID19483718 details
Myd88Tlr9BioGRID30108181 details
Myd88Il1r1BioGRID, DIP, IntAct10854325 16477040 17507369 details
Myd88CblbBioGRID, InnateDB17618294 20639876 details
Myd88BtkInnateDB21441935 details
Myd88IRAK1IntAct21903422 details
Myd88Pik3ap1UniProt22187460 details
Myd88Tlr2DIP, UniProt16832055 29990310 details
Myd88Tnip1BioGRID, DIP22011580 30108181 details
Myd88TLR2UniProt29990310 details
Myd88Lrrfip1BioGRID15952741 details
Myd88Map3k7BioGRID19898473 details
Myd88Becn1BioGRID18772134 details
Myd88Bcl2BioGRID18772134 details
Myd88Irf4BioGRID24670424 details
Myd88RNF152BioGRID31930677 details
Myd88Csf1IntAct16267818 details
Myd88SykInnateDB20639876 details
Myd88Tnfrsf13bInnateDB20676093 details
Myd88Traf2InnateDB20676093 details
Myd88Pik3cdInnateDB23023391 details
Myd88Irak3MINT23376919 details
Myd88Irak2BioGRID, DIP, IntAct22011580 24529375 30108181 details
Myd88TIRAPIntAct24529375 details
Myd88AgerIntAct21829704 details
Myd88Prpf31BioGRID15952741 details
Myd88Tubb4bBioGRID15952741 details
Myd88Tubb5BioGRID15952741 details
Myd88Tuba1cBioGRID15952741 details
Myd88Arl1BioGRID15952741 details
Myd88Lrrfip2BioGRID15952741 details
Myd88FliiBioGRID15952741 details
Myd88Obi1BioGRID15952741 details
Myd88Hspa5BioGRID15952741 details
Myd88Hspa8BioGRID15952741 details
Myd88Stk38BioGRID15952741 details
Myd88Prmt5BioGRID15952741 details
Myd88Tmod3BioGRID15952741 details
Myd88Tbk1BioGRID30108181 details
Myd88Tnip2BioGRID30108181 details
Myd88TankBioGRID30108181 details
Myd88UbcBioGRID30108181 details
Myd88Tnfaip3BioGRID30108181 details