Entity Details

Primary name Pik3r1
Entity type gene
Source Source Link

Details

PrimaryID18708
RefseqGene
SymbolPik3r1
Namephosphoinositide-3-kinase regulatory subunit 1
Chromosome13
Location13 53.92 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsP85A_MOUSE

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0001784 phosphotyrosine residue binding
GO:0001934 positive regulation of protein phosphorylation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005102 signaling receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005801 cis-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007162 negative regulation of cell adhesion
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010459 negative regulation of heart rate
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030183 B cell differentiation
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030971 receptor tyrosine kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033120 positive regulation of RNA splicing
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042307 positive regulation of protein import into nucleus
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043125 ErbB-3 class receptor binding
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0045663 positive regulation of myoblast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045776 negative regulation of blood pressure
GO:0045861 negative regulation of proteolysis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0051117 ATPase binding
GO:0051219 phosphoprotein binding
GO:0051384 response to glucocorticoid
GO:0051491 positive regulation of filopodium assembly
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051591 response to cAMP
GO:0051965 positive regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:0120183 positive regulation of focal adhesion disassembly
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1903076 regulation of protein localization to plasma membrane
GO:1990578 perinuclear endoplasmic reticulum membrane

Diseases

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Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
Pik3r1Ctnnb1BioGRID, IntAct15102471 32325033 details
Pik3r1Brd7IntAct15102471 details
Pik3r1Pik3caBioGRID, DIP, IntAct15102471 18449193 24651434 8947469 details
Pik3r1Sh3gl1BioGRID, IntAct15102471 32325033 details
Pik3r1Pik3cbBioGRID, DIP, IntAct15102471 18449193 32325033 details
Pik3r1Pik3cdI2D, IntAct15102471 22020336 details
Pik3r1Golga3IntAct15102471 details
Pik3r1Eif4g2IntAct15102471 details
Pik3r1Pcbp2IntAct15102471 details
Pik3r1Nme2IntAct15102471 details
Pik3r1CBLBioGRID, MINT9174058 9414268 details
Pik3r1TekBioGRID, MINT10521483 9632797 details
Pik3r1Grb2BioGRID10995764 32325033 9174058 details
Pik3r1Csf1rBioGRID10330148 17420256 32325033 8947469 9312046 details
Pik3r1LckBioGRID9115297 details
Pik3r1KitBioGRID10679268 1370584 22378847 details
Pik3r1Gab1BioGRID11896055 12808090 19401591 details
Pik3r1CrklBioGRID11031258 details
Pik3r1Abi1BioGRID12515821 details
Pik3r1Cd22BioGRID10373493 details
Pik3r1Shc1BioGRID10995764 details
Pik3r1Ptpn11BioGRID10995764 32325033 details
Pik3r1RetBioGRID10995764 details
Pik3r1ArafBioGRID10967104 details
Pik3r1Map6BioGRID26037503 details
Pik3r1IRS1IntAct12679424 details
Pik3r1PdgfrbIntAct15377662 details
Pik3r1PTPN6IntAct12196526 details
Pik3r1HrasBioGRID, IntAct12196526 24470255 32325033 details
Pik3r1Irs1BioGRID, MINT12783867 14684612 14966267 15169905 15183122 15249583 15380067 16455755 18059474 18296638 20804756 27708159 8557661 details
Pik3r1LynMINT8395016 details
Pik3r1BlkMINT8395016 details
Pik3r1FynBioGRID, MINT8395016 9115297 details
Pik3r1TirapMINT19574958 details
Pik3r1ABI1MINT20598684 details
Pik3r1EPORMINT7559499 details
Pik3r1Tie1MINT11865050 details
Pik3r1CD28MINT8621607 details
Pik3r1Ep300BioGRID, I2D21057544 details
Pik3r1Wasf1BioGRID, MINT21946561 32325033 details
Pik3r1Nyap1BioGRID, MINT21946561 details
Pik3r1Myo16BioGRID, MINT21946561 details
Pik3r1CblBioGRID, IntAct10391678 10633073 10799548 10940298 11406619 15581361 15581362 16798838 17420256 20133944 27474268 32325033 8947469 9013636 9115297 9174058 9890970 details
Pik3r1ThrbBioGRID, DIP16446424 17606624 details
Pik3r1SNX9DIP17242350 details
Pik3r1IcosIntAct27135603 details
Pik3r1Irs2BioGRID15169905 15380067 details
Pik3r1Cd19BioGRID11163197 details
Pik3r1Jak2BioGRID22402124 8702385 details
Pik3r1Grin1BioGRID10862698 details
Pik3r1Grin2bBioGRID10862698 details
Pik3r1Tnfrsf11aBioGRID11406619 details
Pik3r1Cd40BioGRID11406619 details
Pik3r1Grb10BioGRID12783867 details
Pik3r1Erbb2BioGRID10940298 details
Pik3r1SH3KBP1BioGRID21725061 details
Pik3r1FosBioGRID9115297 details
Pik3r1Cdh1BioGRID15192701 details
Pik3r1Cdh2BioGRID15192701 details
Pik3r1EporBioGRID17420256 7505116 details
Pik3r1Dok1BioGRID11031258 details
Pik3r1JupBioGRID24567360 details
Pik3r1Akt1BioGRID24567360 details
Pik3r1Pa2g4BioGRID24651434 details
Pik3r1Spp1BioGRID25436971 details
Pik3r1Eps8BioGRID12515821 details
Pik3r1PDGFRABioGRID21393858 details
Pik3r1AxlBioGRID18346204 details
Pik3r1BtlaBioGRID16725108 details
Pik3r1InsrBioGRID7983060 details
Pik3r1Csf1IntAct16267818 details
Pik3r1PIK3CAMINT16043515 details
Pik3r1CrkBioGRID, IntAct20697350 32325033 details
Pik3r1Nckap1BioGRID, MINT21946561 details
Pik3r1Cyfip1BioGRID, MINT21946561 details
Pik3r1LatIntAct24584089 details
Pik3r1Pag1IntAct26512138 details
Pik3r1Snx9DIP17242350 details
Pik3r1WasDIP17242350 details
Pik3r1Cd28DIP17242350 details
Pik3r1Plcg1BioGRID32325033 details
Pik3r1Sh3kbp1BioGRID32325033 details