Entity Details

Primary name Prnp
Entity type gene
Source Source Link

Details

PrimaryID19122
RefseqGene
SymbolPrnp
Nameprion protein
Chromosome2
Location2 64.07 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-25
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsPRIO_MOUSE

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001933 negative regulation of protein phosphorylation
GO:0002020 protease binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005521 lamin binding
GO:0005539 glycosaminoglycan binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006139 nucleobase-containing compound metabolic process
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007611 learning or memory
GO:0008017 microtubule binding
GO:0009986 cell surface
GO:0010942 positive regulation of cell death
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0016234 inclusion body
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0031225 anchored component of membrane
GO:0031648 protein destabilization
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0031965 nuclear membrane
GO:0032147 activation of protein kinase activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032880 regulation of protein localization
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035690 cellular response to drug
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043008 ATP-dependent protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043195 terminal bouton
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051087 chaperone binding
GO:0051260 protein homooligomerization
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071280 cellular response to copper ion
GO:0090314 positive regulation of protein targeting to membrane
GO:0090647 modulation of age-related behavioral decline
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1901379 regulation of potassium ion transmembrane transport
GO:1902430 negative regulation of amyloid-beta formation
GO:1902938 regulation of intracellular calcium activated chloride channel activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905664 regulation of calcium ion import across plasma membrane
GO:1990535 neuron projection maintenance

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
PrnpHNRNPA2B1IntAct16294306 details
PrnpGrb2BioGRID, MINT11571277 15301538 details
PrnpPrnpDIP, MINT, UniProt19805070 20345906 21041683 21441913 22449963 22854022 23892077 details
PrnpNCAM1BioGRID27535221 details
PrnpApoeBioGRID, MINT15146195 32325033 details
PrnpNcam1BioGRID, MINT15146195 32325033 details
PrnpDpp6BioGRID, MINT15146195 24225951 32325033 details
PrnpNcam2BioGRID, MINT15146195 32325033 details
PrnpCntn1BioGRID, MINT15146195 32325033 details
PrnpMagBioGRID, MINT15146195 32325033 details
PrnpDnm1BioGRID, MINT15146195 details
PrnpMogBioGRID, MINT15146195 details
PrnpAplp1MINT15146195 details
PrnpCluBioGRID, MINT15146195 32325033 details
PrnpNectin1BioGRID, MINT15146195 32325033 details
PrnpAdam23BioGRID, MINT15146195 details
PrnpP4hbBioGRID, MINT15146195 details
PrnpSparcl1BioGRID, MINT15146195 32325033 details
PrnpClstn1BioGRID, MINT15146195 32325033 details
PrnpAplp2BioGRID, MINT15146195 32325033 details
PrnpHspa5BioGRID, MINT15146195 32325033 details
PrnpApbb1BioGRID, MINT15146195 details
PrnpAppBioGRID, IntAct15146195 17934213 details
PrnpPsmd6MINT21743439 details
PrnpPsmc2MINT21743439 details
PrnpPRNPMINT22285492 details
PrnpGrm5IntAct24012003 details
PrnpPrndIntAct16766127 details
PrnpCacna2d1IntAct22542184 details
PrnpBACE1DIP17573534 details
PrnpAtp2b2BioGRID15146195 details
PrnpIgsf8BioGRID15146195 details
PrnpCadm3BioGRID15146195 details
PrnpYwhazBioGRID15146195 details
PrnpYwhaeBioGRID15146195 details
PrnpAtp1a3BioGRID15146195 details
PrnpAtp1a1BioGRID15146195 details
PrnpAtp1b1BioGRID15146195 details
PrnpMbpBioGRID15146195 details
PrnpPlp1BioGRID15146195 32325033 details
PrnpGnb1BioGRID15146195 details
PrnpDpysl2BioGRID15146195 details
PrnpPde10aBioGRID15146195 details
PrnpStxbp1BioGRID15146195 details
PrnpSyn1BioGRID11571277 details
PrnpEri3BioGRID11571277 32325033 details
PrnpYwhabIntAct16635246 details
PrnpPSMC2MINT21743439 details
PrnpPSMD6MINT21743439 details
PrnpSERF1BUniProt22854022 details
PrnpSERF1AUniProt22854022 details
PrnpShank3BioGRID, MINT29111324 details
PrnpMaptBioGRID30068389 32325033 details
PrnpPpp1r14aBioGRID32325033 details
PrnpSlc6a1BioGRID32325033 details
PrnpAdap2BioGRID32325033 details
PrnpAldocBioGRID32325033 details
PrnpCnpBioGRID32325033 details
PrnpGpm6aBioGRID32325033 details
PrnpNegr1BioGRID32325033 details
PrnpNptnBioGRID32325033 details
Prnp4833439L19RikBioGRID32325033 details
PrnpSypBioGRID32325033 details
PrnpSyt2BioGRID32325033 details
PrnpCox6b1BioGRID32325033 details
PrnpGnao1BioGRID32325033 details
PrnpNdufs5BioGRID32325033 details
PrnpSlc12a2BioGRID32325033 details
PrnpSppl2aBioGRID32325033 details
PrnpUqcrhBioGRID32325033 details
PrnpCfdBioGRID30550785 details
PrnpFndc5BioGRID30550785 details