Entity Details

Primary name Ptpn11
Entity type gene
Source Source Link

Details

PrimaryID19247
RefseqGene
SymbolPtpn11
Nameprotein tyrosine phosphatase, non-receptor type 11
Chromosome5
Location5
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsPTN11_MOUSE

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0001784 phosphotyrosine residue binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021697 cerebellar cortex formation
GO:0030159 signaling receptor complex adaptor activity
GO:0030220 platelet formation
GO:0030971 receptor tyrosine kinase binding
GO:0031748 D1 dopamine receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032528 microvillus organization
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0036302 atrioventricular canal development
GO:0038127 ERBB signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043254 regulation of protein-containing complex assembly
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044853 plasma membrane raft
GO:0045296 cadherin binding
GO:0045778 positive regulation of ossification
GO:0045931 positive regulation of mitotic cell cycle
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048609 multicellular organismal reproductive process
GO:0048659 smooth muscle cell proliferation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0051894 positive regulation of focal adhesion assembly
GO:0060020 Bergmann glial cell differentiation
GO:0060125 negative regulation of growth hormone secretion
GO:0060325 face morphogenesis
GO:0061582 intestinal epithelial cell migration
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904385 cellular response to angiotensin
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990782 protein tyrosine kinase binding

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
Ptpn11Smarcc1IntAct15102471 details
Ptpn11Heatr6IntAct15102471 details
Ptpn11Luc7l3IntAct15102471 details
Ptpn11KITIntAct7523381 details
Ptpn11GRB2IntAct, MINT11432792 11684012 7522233 7523381 8959326 details
Ptpn11ABI1MINT20598684 details
Ptpn11Grb2BioGRID, IntAct, MINT10995764 11684012 23452850 details
Ptpn11GRB7MINT8622870 details
Ptpn11Ctnnd1MINT9670943 details
Ptpn11Lilrb4aBioGRID, DIP18550825 9973385 details
Ptpn11TekBioGRID10521483 details
Ptpn11SirpaBioGRID11970986 15699129 18450421 8810330 9507023 details
Ptpn11Itsn1BioGRID24216759 details
Ptpn11SPRY2BioGRID24216759 details
Ptpn11Pik3r1BioGRID10995764 32325033 details
Ptpn11CCKBRMINT16963136 details
Ptpn11Ptk2MINT19698715 details
Ptpn11Ptpn11MINT11684012 details
Ptpn11Socs3MINT12403768 details
Ptpn11Ceacam1MINT9867848 details
Ptpn11Jak2MINT17027227 details
Ptpn11Ntrk2MINT21364532 details
Ptpn11Ido1InnateDB21804557 details
Ptpn11FesInnateDB22522491 details
Ptpn11Traf6InnateDB22522491 details
Ptpn11CblBioGRID, IntAct23374343 32325033 9393882 details
Ptpn11PirbDIP, IntAct22660330 24052308 details
Ptpn11ItchBioGRID20417562 details
Ptpn11Inpp5dBioGRID9393882 details
Ptpn11Shc1BioGRID9393882 details
Ptpn11Abl1BioGRID9393882 details
Ptpn11Frs2BioGRID12974390 15870281 details
Ptpn11FasnBioGRID23269672 32325033 details
Ptpn11Cop1BioGRID23269672 details
Ptpn11BtlaBioGRID15568026 details
Ptpn11Tnfrsf14BioGRID15568026 details
Ptpn11LeprBioGRID15520383 details
Ptpn11Gab1BioGRID12808090 15273746 25159185 details
Ptpn11YwhabBioGRID12937170 details
Ptpn11Cd300aBioGRID12893283 details
Ptpn11EgfrBioGRID23027125 details
Ptpn11Dab1BioGRID15062102 details
Ptpn11CblbBioGRID26416283 details
Ptpn11FRS2BioGRID25159185 details
Ptpn11GhrBioGRID9507023 details
Ptpn11Il6stBioGRID9507023 details
Ptpn11Grin1BioGRID, IntAct, MINT10862698 16635246 details
Ptpn11Grin2bBioGRID, IntAct, MINT10862698 16635246 details
Ptpn11Pecam1IntAct10801826 details
Ptpn11LRRK1IntAct20697350 details
Ptpn11SiglecgIntAct23374343 details
Ptpn11Ddx58IntAct23374343 details
Ptpn11WRAP73UniProt26675238 details
Ptpn11Cav3IntAct24952909 details
Ptpn11Actn4BioGRID32325033 details
Ptpn11LifrBioGRID32325033 details
Ptpn11MvpBioGRID32325033 details
Ptpn11Rtf1BioGRID32325033 details
Ptpn11Ptpn2BioGRID32325033 details
Ptpn11Arhgap1BioGRID32325033 details
Ptpn11Plcg1BioGRID32325033 details
Ptpn11PtpraBioGRID32325033 details
Ptpn11SrcBioGRID32325033 details
Ptpn11Sos1BioGRID32325033 details