Entity Details

Primary name Ripk1
Entity type gene
Source Source Link

Details

PrimaryID19766
RefseqGene
SymbolRipk1
Namereceptor (TNFRSF)-interacting serine-threonine kinase 1
Chromosome13
Location13 14.01 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsRIPK1_MOUSE

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005123 death receptor binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0010940 positive regulation of necrotic cell death
GO:0010942 positive regulation of cell death
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034612 response to tumor necrosis factor
GO:0036289 peptidyl-serine autophosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060545 positive regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070513 death domain binding
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097342 ripoptosome
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1990000 amyloid fibril formation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
Ripk1Tnfaip3BioGRID, InnateDB18239685 18246070 21765415 23602765 details
Ripk1HTRA2IntAct20125124 details
Ripk1UbbDIP18719121 26649818 details
Ripk1UbcDIP18719121 26649818 details
Ripk1Rps27aDIP18719121 26649818 details
Ripk1Uba52DIP18719121 26649818 details
Ripk1TnfBioGRID18621737 19955178 24469399 29203883 29891719 30420664 details
Ripk1Khdrbs1BioGRID21620750 details
Ripk1BIRC2BioGRID18621737 details
Ripk1Tnfrsf1aBioGRID, DIP, IntAct, MINT16547522 16680093 18022363 18719121 23602765 29203883 29891719 30209212 details
Ripk1Map3k8BioGRID, IntAct16291755 details
Ripk1FaddBioGRID, DIP, IntAct18946037 19524513 21052097 21368763 22037414 24144979 24557836 26555174 26649818 27458237 29203883 29891719 30209212 30420664 details
Ripk1Ripk3BioGRID, InnateDB, IntAct19524513 22922364 29203883 details
Ripk1ItchBioGRID, InnateDB18246070 21765415 details
Ripk1Ifnar1InnateDB22922364 details
Ripk1Casp8BioGRID, IntAct26555174 29203883 details
Ripk1TraddDIP18719121 details
Ripk1Ticam1DIP22454496 details
Ripk1TNFDIP26649818 details
Ripk1CyldBioGRID17981138 details
Ripk1IkbkgBioGRID17981138 22037414 details
Ripk1Sqstm1BioGRID19850933 details
Ripk1Traf6BioGRID18246070 details
Ripk1Tax1bp1BioGRID18239685 details
Ripk1Il1bBioGRID25607459 details
Ripk1Tlr3BioGRID25828701 details
Ripk1Nek1BioGRID29891719 details
Ripk1Lrrk2BioGRID29891719 details
Ripk1CraddBioGRID11978827 details
Ripk1MavsBioGRID31149635 details
Ripk1TankBioGRID31149635 details
Ripk1TNFSF10MINT21627969 details
Ripk1Traf2BioGRID, InnateDB21765415 details
Ripk1Rnf11BioGRID, InnateDB21765415 details
Ripk1Tlr4DIP18719121 details
Ripk1Atg5BioGRID, DIP18946037 details
Ripk1Tnfrsf4DIP21282629 details
Ripk1Bcl10DIP21282629 details
Ripk1PrkcqDIP21282629 details
Ripk1Malt1DIP21282629 details
Ripk1Card11DIP21282629 details
Ripk1Xpo7IntAct29748336 unassigned1673 details