Entity Details

Primary name Rock1
Entity type gene
Source Source Link

Details

PrimaryID19877
RefseqGene
SymbolRock1
NameRho-associated coiled-coil containing protein kinase 1
Chromosome18
Location18
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-12-03
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsROCK1_MOUSE

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000281 mitotic cytokinesis
GO:0001726 ruffle
GO:0001837 epithelial to mesenchymal transition
GO:0003383 apical constriction
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010494 cytoplasmic stress granule
GO:0010508 positive regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0022614 membrane to membrane docking
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030334 regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0032059 bleb
GO:0032060 bleb assembly
GO:0032091 negative regulation of protein binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042326 negative regulation of phosphorylation
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045616 regulation of keratinocyte differentiation
GO:0045664 regulation of neuron differentiation
GO:0046872 metal ion binding
GO:0048598 embryonic morphogenesis
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051451 myoblast migration
GO:0051894 positive regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090521 glomerular visceral epithelial cell migration
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0140058 neuron projection arborization
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1901888 regulation of cell junction assembly
GO:1902430 negative regulation of amyloid-beta formation
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
Rock1ARHGAP24IntAct16862148 details
Rock1Rnd3MINT18946488 details
Rock1RHOABioGRID9535835 details
Rock1CDC42BioGRID9535835 details
Rock1Casp7BioGRID18723680 details
Rock1Casp3BioGRID18723680 details
Rock1Shroom3BioGRID18829867 details
Rock1MYH9DIP26368311 details
Rock1Rpgrip1lIntAct21565611 details
Rock1Trpm7IntAct24855944 details
Rock1HMGXB4BioGRID, IntAct26496610 details
Rock1ROCK2BioGRID, IntAct26496610 details
Rock1PSRC1BioGRID, IntAct26496610 details
Rock1FBH1BioGRID, IntAct26496610 details
Rock1ENY2BioGRID, IntAct26496610 details
Rock1ATP6V0A2BioGRID, IntAct26496610 details
Rock1SLC39A10BioGRID, IntAct26496610 details
Rock1UBE2MBioGRID, IntAct26496610 details
Rock1DOCK6BioGRID, IntAct26496610 details
Rock1SMARCC1BioGRID, IntAct26496610 details
Rock1RAD51BioGRID, IntAct26496610 details
Rock1CDK2BioGRID, IntAct26496610 details
Rock1SMARCA4BioGRID, IntAct26496610 details
Rock1GPAA1BioGRID, IntAct26496610 details
Rock1CEPT1BioGRID, IntAct26496610 details
Rock1RETREG3BioGRID, IntAct26496610 details
Rock1DOCK5BioGRID, IntAct26496610 details
Rock1Pde4dipBioGRID, IntAct28671696 details
Rock1SSR3BioGRID26496610 details
Rock1IFT88BioGRID26496610 details
Rock1SIRT6BioGRID26496610 details
Rock1STX18BioGRID26496610 details
Rock1GAS2L3BioGRID26496610 details
Rock1Alkbh3BioGRID32325033 details
Rock1Arhgap24BioGRID32325033 details
Rock1HadhaBioGRID32325033 details
Rock1Nudt14BioGRID32325033 details
Rock1Rcsd1BioGRID32325033 details
Rock1Lamp2BioGRID32325033 details
Rock1LgmnBioGRID32325033 details
Rock1S100a11BioGRID32325033 details
Rock1Smc6BioGRID32325033 details
Rock1Taok3BioGRID32325033 details
Rock1Tbc1d5BioGRID32325033 details
Rock1Tnfaip8BioGRID32325033 details
Rock1Washc2BioGRID32325033 details