Entity Details

Primary name Rock2
Entity type gene
Source Source Link

Details

PrimaryID19878
RefseqGene
SymbolRock2
NameRho-associated coiled-coil containing protein kinase 2
Chromosome12
Location12
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-12-03
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsROCK2_MOUSE

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0002931 response to ischemia
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006939 smooth muscle contraction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010825 positive regulation of centrosome duplication
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031267 small GTPase binding
GO:0031616 spindle pole centrosome
GO:0031644 regulation of nervous system process
GO:0032723 positive regulation of connective tissue growth factor production
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0039694 viral RNA genome replication
GO:0042752 regulation of circadian rhythm
GO:0043410 positive regulation of MAPK cascade
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045616 regulation of keratinocyte differentiation
GO:0046872 metal ion binding
GO:0048511 rhythmic process
GO:0048598 embryonic morphogenesis
GO:0048813 dendrite morphogenesis
GO:0051246 regulation of protein metabolic process
GO:0051298 centrosome duplication
GO:0051496 positive regulation of stress fiber assembly
GO:0061157 mRNA destabilization
GO:0071394 cellular response to testosterone stimulus
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090271 positive regulation of fibroblast growth factor production
GO:0097746 blood vessel diameter maintenance
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098974 postsynaptic actin cytoskeleton organization
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0150033 negative regulation of protein localization to lysosome
GO:1900037 regulation of cellular response to hypoxia
GO:1901888 regulation of cell junction assembly
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905145 cellular response to acetylcholine
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
Rock2MTNR1BBioGRID, IntAct26514267 details
Rock2VimBioGRID17015463 details
Rock2Raf1BioGRID, IntAct16365167 19647225 details
Rock2Pfn2BioGRID32325033 9463375 details
Rock2Npm1BioGRID17015463 details
Rock2Tubg1BioGRID17015463 details
Rock2YwhabIntAct16635246 details
Rock2Csf1IntAct16267818 details
Rock2Dlg4BioGRID, IntAct27507650 28671696 details
Rock2Shank3BioGRID, IntAct27507650 28671696 details
Rock2CDC73MINT29774127 details
Rock2Anks1bMINT31388001 details
Rock2Ppp1r9bBioGRID30562941 details
Rock2Dars2BioGRID32325033 details
Rock2ActbBioGRID32325033 details
Rock2Eif4eBioGRID32325033 details
Rock2GphnBioGRID32325033 details
Rock2Lsm14aBioGRID32325033 details
Rock2Ppp1r12aBioGRID32325033 details
Rock2Ppp1r14bBioGRID32325033 details
Rock2RhoaBioGRID32325033 details
Rock2Cdc42BioGRID32325033 details
Rock2Dhx9BioGRID32325033 details
Rock2Dync1i1BioGRID32325033 details
Rock2Hspa8BioGRID32325033 details
Rock2MaptBioGRID32325033 details
Rock2MbpBioGRID32325033 details
Rock2NclBioGRID32325033 details
Rock2Pabpc1BioGRID32325033 details
Rock2Psmc2BioGRID32325033 details
Rock2Rac1BioGRID32325033 details
Rock2Rpl28BioGRID32325033 details
Rock2Rps6BioGRID32325033 details
Rock2Syn1BioGRID32325033 details
Rock2SarnpBioGRID32325033 details
Rock2Stau1BioGRID32325033 details
Rock2Washc2BioGRID32325033 details
Rock2HnrnpuBioGRID32325033 details
Rock2Iqgap1BioGRID32325033 details
Rock2CtshBioGRID32325033 details
Rock2Ddx6BioGRID32325033 details
Rock2InaBioGRID32325033 details
Rock2Pcbp1BioGRID32325033 details
Rock2Rpl6BioGRID32325033 details
Rock2Rplp0BioGRID32325033 details
Rock2Rps4xBioGRID32325033 details
Rock2Washc5BioGRID32325033 details
Rock2Dpysl2BioGRID25921334 details