Entity Details

Primary name Shc1
Entity type gene
Source Source Link

Details

PrimaryID20416
RefseqGene
SymbolShc1
Namesrc homology 2 domain-containing transforming protein C1
Chromosome3
Location3 39.11 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-23
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSHC1_MOUSE

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006940 regulation of smooth muscle contraction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007507 heart development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010008 endosome membrane
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0030182 neuron differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0031175 neuron projection development
GO:0031532 actin cytoskeleton reorganization
GO:0040008 regulation of growth
GO:0042127 regulation of cell population proliferation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0046875 ephrin receptor binding
GO:0048408 epidermal growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051219 phosphoprotein binding
GO:0051721 protein phosphatase 2A binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070435 Shc-EGFR complex
GO:0071363 cellular response to growth factor stimulus
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090322 regulation of superoxide metabolic process
GO:0098609 cell-cell adhesion
GO:1990839 response to endothelin

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
Shc1Inpp5dBioGRID, IntAct10068665 10748054 20697350 8723348 9393882 details
Shc1Grb2BioGRID, IntAct, MINT10362356 10748054 10995764 11259577 17673906 18273058 20697350 23452850 7529871 7535773 7538132 7689150 8479540 9013573 details
Shc1ITGB7MINT12606711 details
Shc1Gab1BioGRID, MINT10871282 12808090 details
Shc1Amd1IntAct15102471 details
Shc1Shcbp1IntAct15102471 details
Shc1ArntlIntAct15102471 details
Shc1Tax1bp1IntAct15102471 details
Shc1Brsk1IntAct15102471 details
Shc1Iqgap1MINT20075861 details
Shc1Ptpn12BioGRID, IntAct, MINT12052829 20075861 20697350 details
Shc1Shc1DIP18413607 details
Shc1Mapk14BioGRID16251354 details
Shc1GRB2BioGRID10202139 10995764 details
Shc1Grap2BioGRID9872323 details
Shc1Pik3r1BioGRID10995764 details
Shc1Ntrk1BioGRID8610109 details
Shc1EGFRIntAct8887653 details
Shc1Tgfbr2MINT17673906 details
Shc1Tgfbr1DIP, MINT17673906 26680585 details
Shc1Sos1BioGRID, MINT17673906 8479540 9013573 details
Shc1IQGAP1MINT20075861 details
Shc1Inppl1BioGRID, IntAct14502564 20697350 details
Shc1Irs1IntAct11259577 details
Shc1ERBB3BioGRID9694850 details
Shc1Socs1BioGRID20622265 details
Shc1APPBioGRID17384289 details
Shc1Csf1rBioGRID10330148 details
Shc1Ptpn11BioGRID9393882 details
Shc1Erbb2BioGRID10940298 details
Shc1AlkBioGRID15226403 details
Shc1EgfrBioGRID20676128 7538132 7689150 details
Shc1SrcBioGRID15716419 details
Shc1SOCS4BioGRID23990909 details
Shc1RETBioGRID10995764 details
Shc1AxlBioGRID8610109 details
Shc1Cd22IntAct10748054 details
Shc1CblBioGRID, IntAct7657591 details
Shc1Tuba4aBioGRID, IntAct20697350 details
Shc1Lrrk1BioGRID, IntAct20697350 details
Shc1LRRK1IntAct20697350 details
Shc1InsrIntAct11259577 details
Shc1Cibar1BioGRID29459677 details
Shc1Ttc23BioGRID29459677 details
Shc1Tedc2BioGRID29459677 details