Entity Details

Primary name C1TC_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ922D8
EntryNameC1TC_MOUSE
FullNameC-1-tetrahydrofolate synthase, cytoplasmic
TaxID10090
Evidenceevidence at protein level
Length935
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesMthfd1

GO terms

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GOName
GO:0000105 histidine biosynthetic process
GO:0001780 neutrophil homeostasis
GO:0001843 neural tube closure
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004486 methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0007507 heart development
GO:0009069 serine family amino acid metabolic process
GO:0009070 serine family amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009257 10-formyltetrahydrofolate biosynthetic process
GO:0019346 transsulfuration
GO:0035999 tetrahydrofolate interconversion
GO:0061053 somite development

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000559 Formate-tetrahydrofolate ligase, FTHFSFamilyFamily
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolaseFamilyFamily
IPR020628 Formate-tetrahydrofolate ligase, FTHFS, conserved siteSiteConserved site
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domainDomainDomain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domainDomainDomain
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
C1TC_MOUSEITB3_MOUSEBioGRID30333137 details