Entity Details

Primary name Sox2
Entity type gene
Source Source Link

Details

PrimaryID20674
RefseqGene
SymbolSox2
NameSRY (sex determining region Y)-box 2
Chromosome3
Location3 16.93 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSOX2_MOUSE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001708 cell fate specification
GO:0001714 endodermal cell fate specification
GO:0002052 positive regulation of neuroblast proliferation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007605 sensory perception of sound
GO:0008134 transcription factor binding
GO:0009653 anatomical structure morphogenesis
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0019827 stem cell population maintenance
GO:0021879 forebrain neuron differentiation
GO:0021984 adenohypophysis development
GO:0021987 cerebral cortex development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030539 male genitalia development
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030910 olfactory placode formation
GO:0031490 chromatin DNA binding
GO:0032526 response to retinoic acid
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0042472 inner ear morphogenesis
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043565 sequence-specific DNA binding
GO:0043586 tongue development
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046148 pigment biosynthetic process
GO:0048286 lung alveolus development
GO:0048568 embryonic organ development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048663 neuron fate commitment
GO:0048839 inner ear development
GO:0048852 diencephalon morphogenesis
GO:0048863 stem cell differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0050973 detection of mechanical stimulus involved in equilibrioception
GO:0060042 retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070848 response to growth factor
GO:0071276 cellular response to cadmium ion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance

Diseases

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Interactions

127 interactions

InteractorPartnerSourcesPublicationsLink
Sox2Hdac1BioGRID, IntAct19139101 21103394 21321941 31077711 details
Sox2Pou5f1BioGRID, IntAct, MINT15863505 17507372 20362541 21962512 22036565 22344693 23108051 31077711 details
Sox2Yy1BioGRID, DIP19536159 31077711 details
Sox2Pax6BioGRID, IntAct20211142 details
Sox2Alx4BioGRID, IntAct20211142 details
Sox2ErgBioGRID, IntAct20211142 details
Sox2Xpo4BioGRID19349578 details
Sox2Ube2iBioGRID17097055 details
Sox2Sall4BioGRID21103394 23269686 31077711 details
Sox2Six1BioGRID22340499 22513373 details
Sox2Eya1BioGRID22340499 22513373 details
Sox2Akt1BioGRID25042802 details
Sox2Nr5a1BioGRID12732652 details
Sox2EsrrbBioGRID23169531 31077711 details
Sox2Cbx1BioGRID31077711 details
Sox2Cbx5BioGRID31077711 details
Sox2Hdac2BioGRID, IntAct19139101 21103394 details
Sox2Sin3aBioGRID, IntAct19139101 31077711 details
Sox2NanogBioGRID, IntAct, MINT18454139 21589869 21962512 23892456 31077711 details
Sox2Ctnnb1BioGRID15781477 details
Sox2Lin28aBioGRID21103394 details
Sox2Sox2BioGRID17507372 21103394 details
Sox2Rad21BioGRID21589869 details
Sox2Wwp2BioGRID25042802 details
Sox2OgtBioGRID22608532 31077711 details
Sox2L3mbtl3BioGRID30442713 details
Sox2Rcor2BioGRID30442713 details
Sox2Cul4aBioGRID30442713 details
Sox2Cul4bBioGRID30442713 details
Sox2Ddb1BioGRID30442713 details
Sox2Dcaf5BioGRID30442713 details
Sox2Rad23bIntAct21962512 details
Sox2Chd4BioGRID, DIP24048479 31077711 details
Sox2Tfe3BioGRID30595499 31077711 details
Sox2HiraBioGRID31077711 details
Sox2Xrcc6BioGRID31077711 details
Sox2HnrnpmBioGRID31077711 details
Sox2Rfc1BioGRID31077711 details
Sox2Tbx3BioGRID31077711 details
Sox2Gatad2bBioGRID31077711 details
Sox2HnrnpcBioGRID31077711 details
Sox2L1td1BioGRID31077711 details
Sox2Arid5bBioGRID31077711 details
Sox2Matr3BioGRID31077711 details
Sox2Ubn2BioGRID31077711 details
Sox2Atf1BioGRID31077711 details
Sox2Rbbp4BioGRID31077711 details
Sox2Akap8BioGRID31077711 details
Sox2Hspa5BioGRID31077711 details
Sox2TfebBioGRID31077711 details
Sox2Ilf3BioGRID31077711 details
Sox2H4c4BioGRID31077711 details
Sox2HnrnpfBioGRID31077711 details
Sox2Atad3aBioGRID31077711 details
Sox2Rcn1BioGRID31077711 details
Sox2Lmnb1BioGRID31077711 details
Sox2Rbfox2BioGRID31077711 details
Sox2Trim28BioGRID31077711 details
Sox2Ddx17BioGRID31077711 details
Sox2Msh2BioGRID31077711 details
Sox2Ranbp2BioGRID31077711 details
Sox2Pum2BioGRID31077711 details
Sox2Fip1l1BioGRID31077711 details
Sox2Hspa8BioGRID31077711 details
Sox2Champ1BioGRID31077711 details
Sox2Fn1BioGRID31077711 details
Sox2HnrnpdBioGRID31077711 details
Sox2Hnrnph1BioGRID31077711 details
Sox2Klf3BioGRID31077711 details
Sox2Ruvbl2BioGRID31077711 details
Sox2Rplp0BioGRID31077711 details
Sox2Rfc3BioGRID31077711 details
Sox2Klf5BioGRID31077711 details
Sox2HnrnpuBioGRID31077711 details
Sox2Nup98BioGRID31077711 details
Sox2Eif2s2BioGRID31077711 details
Sox2Tubb4bBioGRID31077711 details
Sox2Tuba1bBioGRID31077711 details
Sox2Ruvbl1BioGRID31077711 details
Sox2Dnttip1BioGRID31077711 details
Sox2Pcgf2BioGRID31077711 details
Sox2Numa1BioGRID31077711 details
Sox2Ing5BioGRID31077711 details
Sox2Rnf2BioGRID31077711 details
Sox2Kat6bBioGRID31077711 details
Sox2Trerf1BioGRID31077711 details
Sox2NifkBioGRID31077711 details
Sox2Rbm38BioGRID31077711 details
Sox2Tia1BioGRID31077711 details
Sox2Creb1BioGRID31077711 details
Sox2Dazap1BioGRID31077711 details
Sox2EedBioGRID31077711 details
Sox2Srsf1BioGRID31077711 details
Sox2Naa40BioGRID31077711 details
Sox2Smarcd1BioGRID31077711 details
Sox2VimBioGRID31077711 details
Sox2TmpoBioGRID31077711 details
Sox2Smarce1BioGRID31077711 details
Sox2Glyr1BioGRID31077711 details
Sox2Hnrnpa2b1BioGRID31077711 details
Sox2Prpf8BioGRID31077711 details
Sox2Prpf19BioGRID31077711 details
Sox2KhsrpBioGRID31077711 details
Sox2Smarcc1BioGRID31077711 details
Sox2Msh6BioGRID31077711 details
Sox2Kif22BioGRID31077711 details
Sox2Kdm5bBioGRID31077711 details
Sox2Rps7BioGRID31077711 details
Sox2Smc1aBioGRID31077711 details
Sox2Arid1aBioGRID31077711 details
Sox2MagohBioGRID31077711 details
Sox2Rbm8aBioGRID31077711 details
Sox2Supt16BioGRID31077711 details
Sox2Rpl11BioGRID31077711 details
Sox2Nop58BioGRID31077711 details
Sox2Smc3BioGRID31077711 details
Sox2Elavl1BioGRID31077711 details
Sox2Lefty1IntAct22036565 details
Sox2MaxIntAct22036565 details
Sox2D6Wsu163eBioGRID31077711 details
Sox2TraipBioGRID31077711 details
Sox2Prkag2BioGRID31077711 details
Sox2Cetn2BioGRID31077711 details
Sox2Mrps22BioGRID31077711 details
Sox2Mrpl32BioGRID31077711 details
Sox2KaznBioGRID31077711 details
Sox2PsphBioGRID31077711 details