Entity Details

Primary name Sphk1
Entity type gene
Source Source Link

Details

PrimaryID20698
RefseqGene
SymbolSphk1
Namesphingosine kinase 1
Chromosome11
Location11
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSPHK1_MOUSE

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001568 blood vessel development
GO:0001727 lipid kinase activity
GO:0001934 positive regulation of protein phosphorylation
GO:0001956 positive regulation of neurotransmitter secretion
GO:0003677 DNA binding
GO:0003951 NAD+ kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006473 protein acetylation
GO:0006665 sphingolipid metabolic process
GO:0006670 sphingosine metabolic process
GO:0006954 inflammatory response
GO:0007420 brain development
GO:0008021 synaptic vesicle
GO:0008284 positive regulation of cell population proliferation
GO:0008289 lipid binding
GO:0008481 sphinganine kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0016407 acetyltransferase activity
GO:0017050 D-erythro-sphingosine kinase activity
GO:0019371 cyclooxygenase pathway
GO:0019722 calcium-mediated signaling
GO:0030100 regulation of endocytosis
GO:0030139 endocytic vesicle
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031398 positive regulation of protein ubiquitination
GO:0031901 early endosome membrane
GO:0032651 regulation of interleukin-1 beta production
GO:0032740 positive regulation of interleukin-17 production
GO:0034612 response to tumor necrosis factor
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045931 positive regulation of mitotic cell cycle
GO:0045987 positive regulation of smooth muscle contraction
GO:0046512 sphingosine biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050764 regulation of phagocytosis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051721 protein phosphatase 2A binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071363 cellular response to growth factor stimulus
GO:0071897 DNA biosynthetic process
GO:0090520 sphingolipid mediated signaling pathway
GO:0098793 presynapse
GO:0150077 regulation of neuroinflammatory response
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903978 regulation of microglial cell activation
GO:1905364 regulation of endosomal vesicle fusion

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
Sphk1FYNIntAct16316995 details
Sphk1LYNIntAct16316995 details
Sphk1Fhl2IntAct16888242 details