Entity Details

Primary name PER2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO54943
EntryNamePER2_MOUSE
FullNamePeriod circadian protein homolog 2
TaxID10090
Evidenceevidence at protein level
Length1257
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPer2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 transcription corepressor binding
GO:0002931 response to ischemia
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005978 glycogen biosynthetic process
GO:0006094 gluconeogenesis
GO:0006631 fatty acid metabolic process
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0019229 regulation of vasoconstriction
GO:0019249 lactate biosynthetic process
GO:0019900 kinase binding
GO:0031397 negative regulation of protein ubiquitination
GO:0032922 circadian regulation of gene expression
GO:0036002 pre-mRNA binding
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0050767 regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050872 white fat cell differentiation
GO:0051726 regulation of cell cycle
GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0070063 RNA polymerase binding
GO:0070345 negative regulation of fat cell proliferation
GO:0070932 histone H3 deacetylation
GO:0097167 circadian regulation of translation
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1990226 histone methyltransferase binding
GO:2000678 negative regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR022728 Period circadian-like, C-terminalDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
PER2_MOUSEBMAL1_MOUSEBioGRID, DIP, IntAct14701732 16717091 16777965 18430226 20832105 21113167 21680841 22274616 26903623 details
PER2_MOUSECLOCK_MOUSEBioGRID, IntAct14701732 16717091 18430226 18662546 20832105 21113167 21680841 22274616 23555304 32325033 details
PER2_MOUSESIR1_MOUSEBioGRID, IntAct18662546 details
PER2_MOUSESIR1_HUMANIntAct18662546 details
PER2_MOUSECRY2_MOUSEBioGRID, DIP, IntAct, MINT, UniProt14701732 20840750 22170608 23079727 23503662 23555304 24737000 25127877 26903623 details
PER2_MOUSECRY1_MOUSEBioGRID, DIP, IntAct, MINT14701732 21680841 22170608 23079727 23452855 23555304 24413057 24737000 24855952 25127877 details
PER2_MOUSEKC1E_MOUSEBioGRID, DIP, IntAct, MINT15767683 21179498 21680841 23079727 23555304 24413057 details
PER2_MOUSECSK2B_HUMANIntAct23555304 details
PER2_MOUSEBHE40_HUMANIntAct23555304 details
PER2_MOUSERORG_HUMANIntAct23555304 details
PER2_MOUSEBHE41_MOUSEIntAct23555304 details
PER2_MOUSEPER1_MOUSEBioGRID, DIP, IntAct, MINT14701732 20211142 23079727 24737000 32325033 details
PER2_MOUSEPER2_MOUSEBioGRID, DIP, IntAct19402751 20211142 24737000 26903623 details
PER2_MOUSECIART_HUMANDIP24737000 details
PER2_MOUSECLOCK_HUMANDIP24737000 details
PER2_MOUSEPER3_MOUSEBioGRID, DIP14701732 24737000 32325033 details
PER2_MOUSEFOXP1_MOUSEBioGRID, IntAct20211142 details
PER2_MOUSETF2AA_MOUSEBioGRID, IntAct20211142 details
PER2_MOUSETIM_HUMANBioGRID9856465 details
PER2_MOUSETIM_MOUSEBioGRID32325033 9856465 details
PER2_MOUSEXPO1_HUMANBioGRID22833565 details
PER2_MOUSECDK5_MOUSEBioGRID31687929 details
PER2_MOUSEFBW1A_MOUSEBioGRID, IntAct15767683 17462724 26903623 details
PER2_MOUSECAVN3_MOUSEMINT23079727 details
PER2_MOUSEKC1D_MOUSEBioGRID, DIP, MINT21179498 21680841 23079727 details
PER2_MOUSEFBXL3_MOUSEIntAct23452855 23452856 details
PER2_MOUSEFXL21_MOUSEIntAct23452856 details
PER2_MOUSEKC1A_MOUSEDIP21179498 details
PER2_MOUSEMK01_MOUSEDIP21179498 details
PER2_MOUSENR1D1_MOUSEBioGRID, DIP22170608 26903623 details
PER2_MOUSECIART_MOUSEDIP24736997 details
PER2_MOUSENR1D1_HUMANDIP24737000 details
PER2_MOUSEPML_MOUSEBioGRID, IntAct22274616 details
PER2_MOUSEPML_HUMANBioGRID, IntAct22274616 details
PER2_MOUSESFPQ_MOUSEBioGRID21680841 details
PER2_MOUSESIN3A_MOUSEBioGRID21680841 details
PER2_MOUSENONO_MOUSEBioGRID21680841 details
PER2_MOUSEUBP2_MOUSEBioGRID23213472 details