Entity Details

Primary name Stat3
Entity type gene
Source Source Link

Details

PrimaryID20848
RefseqGene
SymbolStat3
Namesignal transducer and activator of transcription 3
Chromosome11
Location11 63.82 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSTAT3_MOUSE

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006606 protein import into nucleus
GO:0006952 defense response
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0014069 postsynaptic density
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019953 sexual reproduction
GO:0030335 positive regulation of cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0031490 chromatin DNA binding
GO:0031730 CCR5 chemokine receptor binding
GO:0032355 response to estradiol
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032870 cellular response to hormone stimulus
GO:0033210 leptin-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035259 glucocorticoid receptor binding
GO:0040014 regulation of multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0042789 mRNA transcription by RNA polymerase II
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043434 response to peptide hormone
GO:0043565 sequence-specific DNA binding
GO:0044320 cellular response to leptin stimulus
GO:0044321 response to leptin
GO:0045471 response to ethanol
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046983 protein dimerization activity
GO:0048708 astrocyte differentiation
GO:0050804 modulation of chemical synaptic transmission
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060019 radial glial cell differentiation
GO:0060259 regulation of feeding behavior
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070878 primary miRNA binding
GO:0071345 cellular response to cytokine stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0072538 T-helper 17 type immune response
GO:0072540 T-helper 17 cell lineage commitment
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097009 energy homeostasis
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904685 positive regulation of metalloendopeptidase activity
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:2000635 negative regulation of primary miRNA processing
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000737 negative regulation of stem cell differentiation
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001223 negative regulation of neuron migration

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
Stat3Hax1IntAct15102471 details
Stat3Hspb1IntAct15102471 details
Stat3Krt1IntAct15102471 details
Stat3Mlf2IntAct15102471 details
Stat3Huwe1IntAct15102471 details
Stat3Bank1IntAct15102471 details
Stat3CryabIntAct, MINT15102471 27724964 details
Stat3Ccp110IntAct15102471 details
Stat3IL6STIntAct, MINT10982829 8662591 details
Stat3SRCIntAct10982829 details
Stat3IFNGR1MINT8662591 details
Stat3STAT3MINT8662591 details
Stat3Stat3BioGRID, DIP, MINT11579100 17463090 20211142 23434585 details
Stat3Dapk3UniProt16219639 details
Stat3SykDIP20133729 details
Stat3JunBioGRID20211142 details
Stat3Jak2BioGRID15143188 21102457 22402124 details
Stat3MAP3K7IntAct15764709 details
Stat3GADD45GIP1MINT18200042 details
Stat3PgrBioGRID, IntAct20876300 21184768 details
Stat3Erbb2IntAct20876300 details
Stat3ECHS1MINT23416296 details
Stat3Cdk6IntAct23948297 details
Stat3SH2B1MINT24396070 details
Stat3Ndufa13BioGRID, IntAct20682646 32325033 details
Stat3Foxp3BioGRID, IntAct19797626 22922362 25126783 25642823 25993445 details
Stat3TDIP16801560 details
Stat3Efnb1DIP17954917 details
Stat3EP300BioGRID10464260 details
Stat3Pcbp1BioGRID17383969 details
Stat3Arid1bBioGRID17255939 details
Stat3Tmf1BioGRID15467733 details
Stat3Jak3BioGRID22402124 details
Stat3Csf1rBioGRID10330148 details
Stat3Irak1BioGRID15465816 details
Stat3PIAS3BioGRID9388184 details
Stat3FerBioGRID12738762 details
Stat3Hes1BioGRID15156153 details
Stat3Zfp467BioGRID12426389 details
Stat3CyldBioGRID23825949 details
Stat3Irf4BioGRID20064451 details
Stat3CRTC2BioGRID27362806 details
Stat3CRTC3BioGRID27362806 details
Stat3Ociad1BioGRID23972987 details
Stat3KdrBioGRID25881542 details
Stat3IL23RIntAct12023369 details
Stat3WRAP73UniProt26675238 details
Stat3LatIntAct24584089 details
Stat3EedBioGRID24457600 details
Stat3ABCG1BioGRID26296893 details
Stat3Il1rapBioGRID32325033 details
Stat3Il6stBioGRID32325033 details
Stat3NfybBioGRID32325033 details
Stat3Hif1aIntAct21871655 details
Stat3Bcl2l1IntAct21184768 details
Stat3Ccnd1IntAct20876300 details
Stat3Il17aIntAct16698929 23021777 25642823 details
Stat3Il1r1IntAct23021777 details
Stat3RorcIntAct23021777 details
Stat3Il12rb1IntAct23021777 details
Stat3Il17fIntAct16698929 23021777 25642823 details
Stat3VegfaIntAct23948297 details
Stat3Cdkn2aIntAct23948297 details
Stat3MMP3IntAct23967200 details
Stat3Il10IntAct21511185 details
Stat3FosIntAct21511185 details
Stat3BanpIntAct25993445 details
Stat3Hdac1IntAct25993445 details
Stat3Il6IntAct19797626 details
Stat3Tgfb1IntAct19797626 details