Entity Details

Primary name PDE2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ922S4
EntryNamePDE2A_MOUSE
FullNamecGMP-dependent 3',5'-cyclic phosphodiesterase
TaxID10090
Evidenceevidence at protein level
Length939
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesPde2a

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000287 magnesium ion binding
GO:0003170 heart valve development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007507 heart development
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0010752 regulation of cGMP-mediated signaling
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010821 regulation of mitochondrion organization
GO:0019933 cAMP-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030424 axon
GO:0030425 dendrite
GO:0030552 cAMP binding
GO:0030553 cGMP binding
GO:0030911 TPR domain binding
GO:0035904 aorta development
GO:0036004 GAF domain binding
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0042301 phosphate ion binding
GO:0042734 presynaptic membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043116 negative regulation of vascular permeability
GO:0043117 positive regulation of vascular permeability
GO:0043949 regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045121 membrane raft
GO:0046069 cGMP catabolic process
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048471 perinuclear region of cytoplasm
GO:0050729 positive regulation of inflammatory response
GO:0060548 negative regulation of cell death
GO:0060976 coronary vasculature development
GO:0061028 establishment of endothelial barrier
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0090324 negative regulation of oxidative phosphorylation
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097060 synaptic membrane
GO:0097457 hippocampal mossy fiber
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion inner membrane
Mitochondrion matrix
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003018 GAF domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR029016 GAF-like domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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