Entity Details

Primary name SIR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ923E4
EntryNameSIR1_MOUSE
FullNameNAD-dependent protein deacetylase sirtuin-1
TaxID10090
Evidenceevidence at protein level
Length737
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSirt1

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 DNA synthesis involved in DNA repair
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001650 fibrillar center
GO:0001678 cellular glucose homeostasis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002039 p53 binding
GO:0002821 positive regulation of adaptive immune response
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006476 protein deacetylation
GO:0006642 triglyceride mobilization
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0007517 muscle organ development
GO:0007623 circadian rhythm
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009267 cellular response to starvation
GO:0010460 positive regulation of heart rate
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010824 regulation of centrosome duplication
GO:0010875 positive regulation of cholesterol efflux
GO:0010883 regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014858 positive regulation of skeletal muscle cell proliferation
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0016575 histone deacetylation
GO:0016605 PML body
GO:0017136 NAD-dependent histone deacetylase activity
GO:0018394 peptidyl-lysine acetylation
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030225 macrophage differentiation
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0030426 growth cone
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031393 negative regulation of prostaglandin biosynthetic process
GO:0031507 heterochromatin assembly
GO:0031648 protein destabilization
GO:0032007 negative regulation of TOR signaling
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033210 leptin-mediated signaling pathway
GO:0033553 rDNA heterochromatin
GO:0033558 protein deacetylase activity
GO:0034391 regulation of smooth muscle cell apoptotic process
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035098 ESC/E(Z) complex
GO:0035356 cellular triglyceride homeostasis
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042326 negative regulation of phosphorylation
GO:0042393 histone binding
GO:0042542 response to hydrogen peroxide
GO:0042595 behavioral response to starvation
GO:0042632 cholesterol homeostasis
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043398 HLH domain binding
GO:0043422 protein kinase B binding
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044321 response to leptin
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045739 positive regulation of DNA repair
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0050872 white fat cell differentiation
GO:0051019 mitogen-activated protein kinase binding
GO:0051097 negative regulation of helicase activity
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051898 negative regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0060125 negative regulation of growth hormone secretion
GO:0060548 negative regulation of cell death
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060907 positive regulation of macrophage cytokine production
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070301 cellular response to hydrogen peroxide
GO:0070403 NAD+ binding
GO:0070829 heterochromatin maintenance
GO:0070857 regulation of bile acid biosynthetic process
GO:0070914 UV-damage excision repair
GO:0070932 histone H3 deacetylation
GO:0071356 cellular response to tumor necrosis factor
GO:0071441 negative regulation of histone H3-K14 acetylation
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0090335 regulation of brown fat cell differentiation
GO:0090400 stress-induced premature senescence
GO:0097009 energy homeostasis
GO:0106230 protein depropionylation
GO:0106231 protein-propionyllysine depropionylase activity
GO:1900113 negative regulation of histone H3-K9 trimethylation
GO:1900181 negative regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1904179 positive regulation of adipose tissue development
GO:1904646 cellular response to amyloid-beta
GO:1990254 keratin filament binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990841 promoter-specific chromatin binding
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000614 positive regulation of thyroid-stimulating hormone secretion
GO:2000619 negative regulation of histone H4-K16 acetylation
GO:2000655 negative regulation of cellular response to testosterone stimulus
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
SIR1_MOUSECLOCK_MOUSEBioGRID, IntAct18662546 18662547 details
SIR1_MOUSEPER2_MOUSEBioGRID, IntAct18662546 details
SIR1_MOUSECSK21_HUMANUniProt19680552 details
SIR1_MOUSEP53_HUMANBioGRID, UniProt11672523 19680552 20167603 details
SIR1_MOUSEFOXO1_HUMANUniProt15220471 details
SIR1_MOUSERB_HUMANUniProt17620057 details
SIR1_MOUSEEP300_HUMANUniProt15632193 details
SIR1_MOUSEDYRK3_MOUSEBioGRID, UniProt20167603 details
SIR1_MOUSEDYR1A_MOUSEBioGRID, UniProt20167603 details
SIR1_MOUSEPRGC1_MOUSEBioGRID, UniProt15716268 15744310 details
SIR1_MOUSEHNF1A_MOUSEBioGRID, UniProt21176092 details
SIR1_MOUSEPPARA_MOUSEBioGRID, UniProt19356714 26443578 details
SIR1_MOUSEHXB1_MOUSEBioGRID, IntAct20211142 details
SIR1_MOUSENFE2_MOUSEBioGRID, IntAct20211142 details
SIR1_MOUSECITE4_MOUSEBioGRID, IntAct20211142 details
SIR1_MOUSENCOR2_MOUSEBioGRID15175761 details
SIR1_MOUSECSK22_HUMANBioGRID19680552 details
SIR1_MOUSEDYR1A_HUMANBioGRID20167603 details
SIR1_MOUSEDYRK3_HUMANBioGRID20167603 details
SIR1_MOUSERXRA_MOUSEBioGRID26443578 details
SIR1_MOUSEBMAL1_MOUSEBioGRID, IntAct18662546 18662547 details
SIR1_MOUSEACACA_MOUSEBioGRID, IntAct19343720 details
SIR1_MOUSEAKT1_MOUSEIntAct21775285 details
SIR1_MOUSEPML_HUMANUniProt12006491 details
SIR1_MOUSEPML_MOUSEUniProt12006491 details
SIR1_MOUSEE2F1_HUMANUniProt16892051 details
SIR1_MOUSERBL1_HUMANUniProt17620057 details
SIR1_MOUSERBL2_HUMANUniProt17620057 details
SIR1_MOUSEHIC1_HUMANUniProt16269335 details
SIR1_MOUSEHIC1_MOUSEUniProt16269335 details
SIR1_MOUSEPPARG_MOUSEBioGRID, IntAct, UniProt15175761 22863012 details
SIR1_MOUSEFOXO3_HUMANUniProt15716268 details
SIR1_MOUSEPRGC1_HUMANUniProt15744310 details
SIR1_MOUSENR1I2_HUMANUniProt21933665 details
SIR1_MOUSEIRS1_MOUSEUniProt17901049 details
SIR1_MOUSEIRS2_MOUSEUniProt17901049 details
SIR1_MOUSESRBP1_MOUSEUniProt20817729 details
SIR1_MOUSESMAD7_MOUSEUniProt17098745 details
SIR1_MOUSESTK11_HUMANUniProt18687677 details
SIR1_MOUSENR0B2_MOUSEBioGRID, UniProt20375098 21081708 details
SIR1_MOUSESNW1_MOUSEBioGRID, UniProt19934264 details
SIR1_MOUSEHEN2_MOUSEIntAct22169038 details
SIR1_MOUSEBCL6_MOUSEIntAct25490446 details
SIR1_MOUSENCOR1_MOUSEDIP18829436 details
SIR1_MOUSEKMT2A_HUMANDIP25751424 details
SIR1_MOUSEKMT2A_MOUSEDIP25751424 details
SIR1_MOUSEBC11A_MOUSEBioGRID15639232 details
SIR1_MOUSETF65_MOUSEBioGRID21454709 details
SIR1_MOUSEEP300_MOUSEBioGRID21454709 details
SIR1_MOUSEERR1_MOUSEBioGRID20484414 details
SIR1_MOUSENR1H4_MOUSEBioGRID19883617 details
SIR1_MOUSEP53_MOUSEBioGRID20157588 details
SIR1_MOUSEPAX3_MOUSEBioGRID21169561 details
SIR1_MOUSEKAT8_MOUSEBioGRID22586264 details
SIR1_MOUSEKAT5_MOUSEBioGRID22586264 details
SIR1_MOUSEMECP2_MOUSEBioGRID22677942 details
SIR1_MOUSEJUN_MOUSEBioGRID18676681 20042607 details
SIR1_MOUSEFOS_MOUSEBioGRID20042607 details
SIR1_MOUSEJUND_MOUSEBioGRID18676681 details
SIR1_MOUSEIRS2_HUMANBioGRID17901049 details
SIR1_MOUSEFOXO1_MOUSEBioGRID22514318 details
SIR1_MOUSENECD_MOUSEBioGRID22514318 details
SIR1_MOUSECBX5_MOUSEBioGRID28059589 details
SIR1_MOUSEOBI1_MOUSEBioGRID32220064 details