Entity Details

Primary name TF7L2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ924A0
EntryNameTF7L2_MOUSE
FullNameTranscription factor 7-like 2
TaxID10090
Evidenceevidence at protein level
Length459
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesTcf7l2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001678 cellular glucose homeostasis
GO:0001701 in utero embryonic development
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0005977 glycogen metabolic process
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 oligodendrocyte development
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030282 bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0030538 embryonic genitalia morphogenesis
GO:0031641 regulation of myelination
GO:0032024 positive regulation of insulin secretion
GO:0032092 positive regulation of protein binding
GO:0032252 secretory granule localization
GO:0032350 regulation of hormone metabolic process
GO:0032993 protein-DNA complex
GO:0035019 somatic stem cell population maintenance
GO:0035264 multicellular organism growth
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0043570 maintenance of DNA repeat elements
GO:0043588 skin development
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 gamma-catenin binding
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046621 negative regulation of organ growth
GO:0046827 positive regulation of protein export from nucleus
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048557 embryonic digestive tract morphogenesis
GO:0048619 embryonic hindgut morphogenesis
GO:0048625 myoblast fate commitment
GO:0048641 regulation of skeletal muscle tissue development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070016 armadillo repeat domain binding
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901142 insulin metabolic process
GO:1990907 beta-catenin-TCF complex
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR013558 CTNNB1 binding, N-teminalDomainDomain
IPR024940 Transcription factor TCF/LEFFamilyFamily
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table