Entity Details

Primary name Arrb2
Entity type gene
Source Source Link

Details

PrimaryID216869
RefseqGene
SymbolArrb2
Namearrestin, beta 2
Chromosome11
Location11 42.99 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2002-05-05
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsARRB2_MOUSE

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G protein-coupled receptor internalization
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006366 transcription by RNA polymerase II
GO:0006897 endocytosis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0015031 protein transport
GO:0016323 basolateral plasma membrane
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030139 endocytic vesicle
GO:0031397 negative regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031625 ubiquitin protein ligase binding
GO:0031691 alpha-1A adrenergic receptor binding
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031762 follicle-stimulating hormone receptor binding
GO:0031826 type 2A serotonin receptor binding
GO:0031859 platelet activating factor receptor binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 dendritic spine
GO:0043422 protein kinase B binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045211 postsynaptic membrane
GO:0045860 positive regulation of protein kinase activity
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051019 mitogen-activated protein kinase binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071889 14-3-3 protein binding
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1990763 arrestin family protein binding
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000727 positive regulation of cardiac muscle cell differentiation

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
Arrb2Traf6BioGRID16378096 23960234 details
Arrb2Ppp2caBioGRID16051150 details
Arrb2Ppp2r2bBioGRID16051150 details
Arrb2Gsk3bBioGRID16051150 details
Arrb2Gsk3aBioGRID16051150 details
Arrb2Itga2bBioGRID30333137 details
Arrb2HTR2CIntAct16319069 details
Arrb2Ffar4IntAct20813258 details
Arrb2Tab1IntAct20813258 details
Arrb2TAB1IntAct20813258 details
Arrb2Nphs1DIP16968782 details
Arrb2Card10DIP18952848 details
Arrb2Akt1BioGRID, DIP16051150 19122674 details
Arrb2Pde4dDIP19955404 details
Arrb2Arrb1BioGRID19122674 details
Arrb2SrcBioGRID19122674 details
Arrb2Mdm2BioGRID11588219 details
Arrb2ItchBioGRID29515120 32325033 details
Arrb2HMMRBioGRID, IntAct26496610 details
Arrb2FLNABioGRID, IntAct26496610 details
Arrb2PPP1CBBioGRID, IntAct26496610 details
Arrb2PKN3BioGRID, IntAct26496610 details
Arrb2MUC13BioGRID, IntAct26496610 details
Arrb2WDR6BioGRID, IntAct26496610 details
Arrb2STRN3BioGRID, IntAct26496610 details
Arrb2INF2BioGRID, IntAct26496610 details
Arrb2TFE3BioGRID, IntAct26496610 details
Arrb2FBXO46BioGRID, IntAct26496610 details
Arrb2PPP1CABioGRID, IntAct26496610 details
Arrb2TCOF1BioGRID, IntAct26496610 details
Arrb2COBLBioGRID, IntAct26496610 details
Arrb2STRNBioGRID, IntAct26496610 details
Arrb2PJA2BioGRID, IntAct26496610 details
Arrb2CTTNBP2NLBioGRID, IntAct26496610 details
Arrb2MOB4BioGRID, IntAct26496610 details
Arrb2VPS51BioGRID, IntAct26496610 details
Arrb2SPTBN1BioGRID, IntAct26496610 details
Arrb2RAB11FIP5BioGRID, IntAct26496610 details
Arrb2NOLC1BioGRID, IntAct26496610 details
Arrb2JAK1BioGRID, IntAct26496610 details
Arrb2BASP1BioGRID, IntAct26496610 details
Arrb2InsrBioGRID, DIP19122674 details
Arrb2RASSF8BioGRID26496610 details
Arrb2Atg16l1BioGRID30196744 details
Arrb2Rangap1BioGRID32325033 details
Arrb2Rpl12BioGRID32325033 details
Arrb2Capza2BioGRID32325033 details
Arrb2Ndufs7BioGRID32325033 details
Arrb2Sucla2BioGRID32325033 details
Arrb2Cotl1BioGRID32325033 details