Entity Details

Primary name SPRE1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ924S8
EntryNameSPRE1_MOUSE
FullNameSprouty-related, EVH1 domain-containing protein 1
TaxID10090
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesSpred1

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0005173 stem cell factor receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006469 negative regulation of protein kinase activity
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010923 negative regulation of phosphatase activity
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031410 cytoplasmic vesicle
GO:0043409 negative regulation of MAPK cascade
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090311 regulation of protein deacetylation
GO:1902747 negative regulation of lens fiber cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000697 WH1/EVH1 domainDomainDomain
IPR007875 SproutyFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR023337 c-Kit-binding domainDomainDomain
IPR041937 SPRE, EVH1 domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SPRE1_MOUSENF1_HUMANIntAct26635368 details
SPRE1_MOUSEZDH17_HUMANIntAct24705354 details