Entity Details

Primary name Tgfbr1
Entity type gene
Source Source Link

Details

PrimaryID21812
RefseqGene
SymbolTgfbr1
Nametransforming growth factor, beta receptor I
Chromosome4
Location4 26.02 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-19
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsTGFR1_MOUSE

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005102 signaling receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005923 bicellular tight junction
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008584 male gonad development
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016361 activin receptor activity, type I
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031396 regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032924 activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0035556 intracellular signal transduction
GO:0042118 endothelial cell activation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043393 regulation of protein binding
GO:0043542 endothelial cell migration
GO:0043627 response to estrogen
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048538 thymus development
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048762 mesenchymal cell differentiation
GO:0048844 artery morphogenesis
GO:0048870 cell motility
GO:0050431 transforming growth factor beta binding
GO:0051272 positive regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060021 roof of mouth development
GO:0060037 pharyngeal system development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0070411 I-SMAD binding
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905075 positive regulation of tight junction disassembly
GO:1905223 epicardium morphogenesis
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
Tgfbr1Tssk5MINT15761153 details
Tgfbr1DiabloMINT15761153 details
Tgfbr1GDF11MINT16845371 details
Tgfbr1Shc1DIP, MINT17673906 26680585 details
Tgfbr1EngMINT18337748 details
Tgfbr1Cdh5MINT18337748 details
Tgfbr1Tgfbr2BioGRID, DIP, IntAct, MINT12070302 18337748 20603020 21518866 details
Tgfbr1Dact2UniProt21718540 details
Tgfbr1Dact1UniProt21718540 details
Tgfbr1DLG5MINT23624079 details
Tgfbr1Cd44IntAct25065622 details
Tgfbr1Ly6aDIP21518866 details
Tgfbr1SMAD3DIP26680585 details
Tgfbr1AP2B1DIP26680585 details
Tgfbr1Cav1DIP26680585 details
Tgfbr1Ap2b1DIP26680585 details
Tgfbr1XiapBioGRID19531477 details
Tgfbr1OclnBioGRID15761153 details
Tgfbr1Acvrl1BioGRID14580334 details
Tgfbr1Gdf11BioGRID16845371 details
Tgfbr1Smurf2BioGRID25885904 details
Tgfbr1NesIntAct20603020 details
Tgfbr1PQBP1BioGRID, IntAct26496610 details
Tgfbr1CTNNA1BioGRID, IntAct26496610 details
Tgfbr1GALNT1BioGRID, IntAct26496610 details
Tgfbr1PLXNB1BioGRID, IntAct26496610 details
Tgfbr1MIER1BioGRID, IntAct26496610 details
Tgfbr1NBPF12IntAct26496610 details
Tgfbr1PDIA3BioGRID, IntAct26496610 details
Tgfbr1SLC35E1BioGRID, IntAct26496610 details
Tgfbr1ACAD8BioGRID, IntAct26496610 details
Tgfbr1BLMHBioGRID, IntAct26496610 details
Tgfbr1INTS7BioGRID, IntAct26496610 details
Tgfbr1HLA-CBioGRID, IntAct26496610 details
Tgfbr1NSMCE2BioGRID, IntAct26496610 details
Tgfbr1TGFBR1BioGRID15761153 details
Tgfbr1ACVR1BioGRID15761153 details
Tgfbr1BMPR1BBioGRID15761153 details
Tgfbr1HSPA8BioGRID26496610 details
Tgfbr1PABPN1BioGRID26496610 details