Entity Details

Primary name Traf2
Entity type gene
Source Source Link

Details

PrimaryID22030
RefseqGene
SymbolTraf2
NameTNF receptor-associated factor 2
Chromosome2
Location2
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-19
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsTRAF2_MOUSE

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0002637 regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0012506 vesicle membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030163 protein catabolic process
GO:0030674 protein-macromolecule adaptor activity
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032743 positive regulation of interleukin-2 production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034622 cellular protein-containing complex assembly
GO:0035631 CD40 receptor complex
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043120 tumor necrosis factor binding
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043507 positive regulation of JUN kinase activity
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046625 sphingolipid binding
GO:0048255 mRNA stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0070534 protein K63-linked ubiquitination
GO:0071732 cellular response to nitric oxide
GO:0097057 TRAF2-GSTP1 complex
GO:0097300 programmed necrotic cell death
GO:0097400 interleukin-17-mediated signaling pathway
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1990604 IRE1-TRAF2-ASK1 complex
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
Traf2Tnfrsf4DIP, IntAct21282629 9418902 details
Traf2Tnfrsf9IntAct9418902 details
Traf2TNFRSF14IntAct9153189 details
Traf2Tnfrsf14IntAct9153189 details
Traf2TNFRSF8BioGRID, IntAct8627180 details
Traf2TankIntAct15102471 details
Traf2Mknk2IntAct15102471 details
Traf2FcrlaIntAct15102471 details
Traf2Tnfaip3BioGRID, InnateDB, IntAct15102471 20185725 21765415 details
Traf2Cog2IntAct15102471 details
Traf2IkbipIntAct15102471 details
Traf2Zmiz1IntAct15102471 details
Traf2Birc3BioGRID, IntAct15102471 21765415 details
Traf2Birc2InnateDB, IntAct15102471 21765415 details
Traf2SlmapIntAct15102471 details
Traf2Traf2IntAct15102471 details
Traf2Lzts2IntAct15102471 details
Traf2SharpinBioGRID, IntAct15102471 21829440 details
Traf2Nup98IntAct15102471 details
Traf2Bri3bpIntAct15102471 details
Traf2LtbrBioGRID, DIP, IntAct15102471 23334419 details
Traf2RHEBL1BioGRID, IntAct20368287 details
Traf2RHEBBioGRID, IntAct20368287 details
Traf2Tnfrsf11aIntAct10097072 details
Traf2Rb1cc1BioGRID17015619 details
Traf2Cdk9BioGRID9827693 details
Traf2Map3k5BioGRID17015619 details
Traf2TifaBioGRID11798190 details
Traf2Cd27BioGRID, IntAct20974987 9692890 details
Traf2EDARBioGRID, IntAct11035039 details
Traf2Cd40BioGRID, DIP, MINT10748240 17919601 18635759 23334419 25072696 details
Traf2Traf3I2D20818435 details
Traf2Ube2nBioGRID, InnateDB20185725 21765415 details
Traf2ItchBioGRID, InnateDB20185725 21765415 details
Traf2CASP10IntAct12884866 details
Traf2CASP8IntAct12884866 details
Traf2Map3k7BioGRID, InnateDB22057290 details
Traf2BIRC2BioGRID, IntAct21903422 8548810 details
Traf2Irak1IntAct24706909 details
Traf2TNFRSF19BioGRID10809768 details
Traf2Ube2d3BioGRID20185725 details
Traf2Rnf11BioGRID20185725 details
Traf2Tax1bp1BioGRID20185725 21765415 details
Traf2IkbkgBioGRID18635759 23951545 details
Traf2Fhl2BioGRID16184196 details
Traf2Tnfrsf13cBioGRID21041452 details
Traf2MavsBioGRID23951545 details
Traf2Nedd4BioGRID25072696 details
Traf2Creb1BioGRID26755589 details
Traf2Mapkbp1BioGRID19385034 details
Traf2Tbk1MINT10581243 details
Traf2Tnfrsf1aDIP, HPIDb, IntAct11374864 18022363 18719121 details
Traf2Tnfrsf13bInnateDB20676093 details
Traf2Myd88InnateDB20676093 details
Traf2Ripk1BioGRID, InnateDB21765415 details
Traf2TAX1BP1InnateDB21765415 details
Traf2Traf3ip2InnateDB21822257 details
Traf2TRAF3IntAct21903422 details
Traf2TRAF1IntAct21903422 details
Traf2DIABLOIntAct21903422 details
Traf2TANKIntAct21903422 details
Traf2TBK1IntAct21903422 details
Traf2CD40BioGRID, DIP23334419 details
Traf2TNFDIP26649818 details