Entity Details

Primary name Trp53
Entity type gene
Source Source Link

Details

PrimaryID22059
RefseqGene
SymbolTrp53
Nametransformation related protein 53
Chromosome11
Location11 42.83 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsP53_MOUSE

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000733 obsolete DNA strand renaturation
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0001216 DNA-binding transcription activator activity
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001836 release of cytochrome c from mitochondria
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002309 T cell proliferation involved in immune response
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002687 positive regulation of leukocyte migration
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003730 mRNA 3'-UTR binding
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription regulator complex
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006606 protein import into nucleus
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006979 response to oxidative stress
GO:0006983 ER overload response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007369 gastrulation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007569 cell aging
GO:0007623 circadian rhythm
GO:0008022 protein C-terminus binding
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell population proliferation
GO:0008340 determination of adult lifespan
GO:0009299 mRNA transcription
GO:0009303 rRNA transcription
GO:0009411 response to UV
GO:0009651 response to salt stress
GO:0009792 embryo development ending in birth or egg hatching
GO:0010038 response to metal ion
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016032 viral process
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021549 cerebellum development
GO:0030308 negative regulation of cell growth
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030971 receptor tyrosine kinase binding
GO:0031000 response to caffeine
GO:0031065 positive regulation of histone deacetylation
GO:0031497 chromatin assembly
GO:0031571 mitotic G1 DNA damage checkpoint signaling
GO:0031625 ubiquitin protein ligase binding
GO:0032526 response to retinoic acid
GO:0032991 protein-containing complex
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033552 response to vitamin B3
GO:0034103 regulation of tissue remodeling
GO:0034605 cellular response to heat
GO:0034613 cellular protein localization
GO:0034614 cellular response to reactive oxygen species
GO:0034644 cellular response to UV
GO:0035033 histone deacetylase regulator activity
GO:0035035 histone acetyltransferase binding
GO:0035264 multicellular organism growth
GO:0035690 cellular response to drug
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035861 site of double-strand break
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043200 response to amino acid
GO:0043504 mitochondrial DNA repair
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0045471 response to ethanol
GO:0045787 positive regulation of cell cycle
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0048147 negative regulation of fibroblast proliferation
GO:0048512 circadian behavior
GO:0048539 bone marrow development
GO:0048568 embryonic organ development
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051262 protein tetramerization
GO:0051276 chromosome organization
GO:0051402 neuron apoptotic process
GO:0051453 regulation of intracellular pH
GO:0051721 protein phosphatase 2A binding
GO:0051726 regulation of cell cycle
GO:0051974 negative regulation of telomerase activity
GO:0055093 response to hyperoxia
GO:0060218 hematopoietic stem cell differentiation
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060411 cardiac septum morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0062100 positive regulation of programmed necrotic cell death
GO:0065003 protein-containing complex assembly
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070243 regulation of thymocyte apoptotic process
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070266 necroptotic process
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0071494 cellular response to UV-C
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072717 cellular response to actinomycin D
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090343 positive regulation of cell aging
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097252 oligodendrocyte apoptotic process
GO:0097371 MDM2/MDM4 family protein binding
GO:0097718 disordered domain specific binding
GO:1900119 positive regulation of execution phase of apoptosis
GO:1901525 negative regulation of mitophagy
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
GO:1905856 negative regulation of pentose-phosphate shunt
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damage
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990841 promoter-specific chromatin binding
GO:2000269 regulation of fibroblast apoptotic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000772 regulation of cellular senescence
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

Show/Hide Table

Interactions

133 interactions

InteractorPartnerSourcesPublicationsLink
Trp53Hmgb1MINT11748221 details
Trp53CHD3IntAct15383276 details
Trp53PIAS4IntAct11388671 15383276 details
Trp53TP53IntAct15383276 details
Trp53ZHX1IntAct15383276 details
Trp53Ep300BioGRID, DIP, I2D, IntAct10706102 14555661 21057544 22666487 25117711 9194565 details
Trp53ATMIntAct17157788 details
Trp53CHEK2IntAct17157788 details
Trp53Ppp1ccBioGRID, IntAct17274640 details
Trp53Mapkapk5IntAct17254968 details
Trp53Mdm2BioGRID, DIP, I2D, IntAct10205143 10706102 10982879 11953423 14555661 17086174 17936560 18309296 18359851 18566590 18695251 19556538 20697359 20818388 20832751 21183956 21738215 21857681 22216266 22666487 22805162 23580573 25117711 25732823 30545932 30578299 8058315 9732264 details
Trp53Smarcd1BioGRID, IntAct18303029 details
Trp53VRK1IntAct10951572 details
Trp53TOPORSBioGRID, UniProt10415337 11842245 details
Trp53Trp53BioGRID, DIP11152481 16717092 20211142 25119037 8035799 details
Trp53Zfp292BioGRID, IntAct20211142 details
Trp53TP53BP1BioGRID16169070 details
Trp53CSNK1EBioGRID9349507 details
Trp53MAPK8BioGRID9393873 details
Trp53MAPK9BioGRID9393873 details
Trp53MAPK10BioGRID9393873 details
Trp53ING4BioGRID17325660 details
Trp53NfkbiaBioGRID20211142 details
Trp53Sin3aBioGRID20211142 details
Trp53Trp63BioGRID20211142 23251530 details
Trp53Trp73BioGRID20211142 23251530 details
Trp53HABP4BioGRID16455055 details
Trp53MDM2BioGRID12771937 14555661 22991965 details
Trp53Pias4BioGRID16816390 details
Trp53Pias1BioGRID16816390 details
Trp53Pias2BioGRID16816390 details
Trp53Pax3BioGRID22216266 details
Trp53Cdk2BioGRID16102793 details
Trp53ITSN1BioGRID22558309 details
Trp53UBE2L3BioGRID8144545 details
Trp53SkilBioGRID19745809 22805162 details
Trp53Smyd1BioGRID12011100 details
Trp53Rchy1BioGRID24367557 details
Trp53PRKAA1BioGRID15866171 details
Trp53AtmBioGRID21706008 details
Trp53Brinp1BioGRID25732823 details
Trp53Kcnma1BioGRID25581503 details
Trp53HSPA8BioGRID8940078 details
Trp53MelkBioGRID22532570 details
Trp53Dmc1BioGRID14764457 details
Trp53Ep400DIP9194565 details
Trp53Bcl2l1BioGRID, IntAct14963330 16151013 30683842 details
Trp53BCL2L1IntAct16151013 details
Trp53Hspa1lMINT10637512 details
Trp53UbbDIP, MINT18309296 21730132 21857681 details
Trp53UbcDIP, MINT18309296 21730132 21857681 details
Trp53Rps27aDIP, MINT18309296 21730132 21857681 details
Trp53Uba52DIP, MINT18309296 21730132 21857681 details
Trp53Bard1BioGRID, UniProt11779501 15782130 details
Trp53EP300IntAct18612383 details
Trp53DaxxBioGRID, MINT15364927 18566590 details
Trp53Apbb1MINT19796171 details
Trp53Mdm4BioGRID, DIP, I2D, IntAct11953423 19573810 20697359 21730132 25981963 details
Trp53Mapk14BioGRID, MINT21050851 details
Trp53Cdkn1aBioGRID, I2D, IntAct21057544 22666487 23410974 details
Trp53PIN1IntAct21741598 details
Trp53Pin1IntAct21741598 details
Trp53PpifIntAct22726440 details
Trp53Sod2I2D21909133 details
Trp53Twist1BioGRID, IntAct22975381 details
Trp53PtenBioGRID, MINT18332125 23123091 details
Trp53Gfi1IntAct23410974 details
Trp53Bbc3BioGRID, IntAct23410974 24553927 details
Trp53Ppp1r13lIntAct23623661 details
Trp53Ybx1IntAct24788519 details
Trp53Bach1DIP19011633 details
Trp53Trim24DIP19556538 details
Trp53Ruvbl1IntAct25857266 details
Trp53Ddb1BioGRID17967871 details
Trp53Ube2nBioGRID17000756 details
Trp53PrkdcBioGRID15792956 details
Trp53Kmt2eBioGRID21423215 details
Trp53NPM1BioGRID17277230 details
Trp53Npm1BioGRID17277230 details
Trp53Sirt1BioGRID20157588 details
Trp53Sp1BioGRID20157588 details
Trp53Ptk2bBioGRID19880522 details
Trp53Smarca4BioGRID18303029 details
Trp53Huwe1BioGRID22754359 details
Trp53Mapk8BioGRID10706102 15580310 9732264 details
Trp53NUMBBioGRID9632782 details
Trp53Ccng1BioGRID11983168 details
Trp53Park7BioGRID19680261 details
Trp53Zbtb7cBioGRID22253232 details
Trp53Gsk3bBioGRID21738215 details
Trp53ToporsBioGRID15735665 details
Trp53Hspa1bBioGRID23251530 details
Trp53Cdkn2aBioGRID10706102 15989966 9653180 details
Trp53Axin1BioGRID15526030 details
Trp53Hipk2BioGRID15526030 details
Trp53WwoxBioGRID15580310 details
Trp53Rpl11BioGRID15989966 details
Trp53Rps26BioGRID23728348 details
Trp53Herc2BioGRID24722987 details
Trp53NdnBioGRID24911587 details
Trp53Rnf128BioGRID23370271 details
Trp53Rev1BioGRID25614517 details
Trp53Dapk1BioGRID25139875 details
Trp53PrknBioGRID28395174 details
Trp53Cul7BioGRID24793696 details
Trp53VegfaBioGRID23449391 details
Trp53Psmd10BioGRID30109252 details
Trp53Rad51BioGRID14764457 details
Trp53Usp7BioGRID30545932 details
Trp53Klf4BioGRID30578299 details
Trp53IRS1BioGRID30578299 details
Trp53Irs1BioGRID30578299 details
Trp53Bcl2BioGRID30683842 details
Trp53Tmub1BioGRID31867855 details
Trp53SMARCA4BioGRID, IntAct18303029 details
Trp53SMARCC1BioGRID, IntAct18303029 details
Trp53MafkDIP19011633 details
Trp53Hdac1DIP19011633 details
Trp53Trp53bp1DIP19556538 details
Trp53Prdm16MINT29320702 details
Trp53Foxp3BioGRID22922362 details
Trp53Aifm2BioGRID32325033 details
Trp53Ankrd2BioGRID32325033 details
Trp53EcdBioGRID32325033 details
Trp53Hephl1BioGRID32325033 details
Trp53Rdh13BioGRID32325033 details
Trp53Usf1IntAct19303849 details
Trp53PerpI2D21057544 details
Trp53Egr2IntAct23410974 details
Trp53Ddb2IntAct23410974 details
Trp53Pmaip1IntAct23410974 details
Trp53BaxIntAct23410974 details
Trp53Id2IntAct23410974 details