Entity Details

Primary name FOXP3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ99JB6
EntryNameFOXP3_MOUSE
FullNameForkhead box protein P3
TaxID10090
Evidenceevidence at protein level
Length429
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesFoxp3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001782 B cell homeostasis
GO:0001818 negative regulation of cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO:0002456 T cell mediated immunity
GO:0002507 tolerance induction
GO:0002513 tolerance induction to self antigen
GO:0002637 regulation of immunoglobulin production
GO:0002666 positive regulation of T cell tolerance induction
GO:0002667 regulation of T cell anergy
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014045 establishment of endothelial blood-brain barrier
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0035035 histone acetyltransferase binding
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050687 negative regulation of defense response to virus
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0051525 NFAT protein binding
GO:1901355 response to rapamycin
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032354 FOXP, coiled-coil domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
FOXP3_MOUSENFAC2_MOUSEBioGRID, DIP, IntAct17377532 20064450 22922362 25126782 details
FOXP3_MOUSESTAT3_MOUSEBioGRID, IntAct19797626 22922362 25126783 25642823 25993445 details
FOXP3_MOUSEGATA3_MOUSEBioGRID, IntAct21131965 22922362 details
FOXP3_MOUSEBC11B_MOUSEBioGRID, IntAct21875956 22922362 details
FOXP3_MOUSERUNX1_MOUSEDIP17377532 details
FOXP3_MOUSERORG_MOUSEDIP18368049 details
FOXP3_MOUSEFOXP3_MOUSEDIP, IntAct16769892 25126782 details
FOXP3_MOUSEHDAC2_MOUSEBioGRID, IntAct22922362 26365427 details
FOXP3_MOUSEIRF4_MOUSEDIP19182775 details
FOXP3_MOUSEPPARG_MOUSEDIP22722857 details
FOXP3_MOUSEUBP44_MOUSEMINT32644293 details
FOXP3_MOUSEKAT5_MOUSEBioGRID22579476 details
FOXP3_MOUSEEP300_MOUSEBioGRID22579476 details
FOXP3_MOUSEHDAC7_MOUSEBioGRID22579476 details
FOXP3_MOUSEIKZF4_MOUSEBioGRID22579476 details
FOXP3_MOUSERL40_MOUSEBioGRID22579476 details
FOXP3_MOUSEASH2L_MOUSEBioGRID22922362 details
FOXP3_MOUSEPEBB_MOUSEBioGRID22922362 details
FOXP3_MOUSECHD4_MOUSEBioGRID22922362 details
FOXP3_MOUSEFOXP1_MOUSEBioGRID22922362 details
FOXP3_MOUSEIKZF3_MOUSEBioGRID22922362 details
FOXP3_MOUSEKDM1A_MOUSEBioGRID22922362 details
FOXP3_MOUSERCOR1_MOUSEBioGRID22922362 details
FOXP3_MOUSESMCA4_MOUSEBioGRID22922362 details
FOXP3_MOUSESMCA5_MOUSEBioGRID22922362 details
FOXP3_MOUSESMRC1_MOUSEBioGRID22922362 details
FOXP3_MOUSESMCE1_MOUSEBioGRID22922362 details
FOXP3_MOUSECHIP_MOUSEBioGRID23973223 details
FOXP3_MOUSEBRD9_MOUSEBioGRID32640256 details