Entity Details

Primary name NCK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO55033
EntryNameNCK2_MOUSE
FullNameCytoplasmic protein NCK2
TaxID10090
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated2012-01-25
DateModified2021-06-02

Ontological Relatives

GenesNck2

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001784 phosphotyrosine residue binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0007015 actin filament organization
GO:0012506 vesicle membrane
GO:0014069 postsynaptic density
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042102 positive regulation of T cell proliferation
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048013 ephrin receptor signaling pathway
GO:0060996 dendritic spine development
GO:0097110 scaffold protein binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR017304 Cytoplasmic protein NCKFamilyFamily
IPR028524 Cytoplasmic protein NCK2FamilyFamily
IPR035559 Nck2, SH3 domain 1DomainDomain
IPR035560 Nck2, SH3 domain 2DomainDomain
IPR035561 Nck2, SH3 domain 3DomainDomain
IPR035883 Nck2, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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